Pulsed magnetic field enhances therapeutic efficiency of mesenchymal stem cells in chronic neuropathic pain model

2017 ◽  
Vol 38 (4) ◽  
pp. 255-264 ◽  
Author(s):  
Tufan Mert ◽  
Akif Hakan Kurt ◽  
İdiris Altun ◽  
Ahmet Celik ◽  
Furkan Baran ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neuropathic Pain ◽  
Pulsed Magnetic Field ◽  
Chronic Neuropathic Pain ◽  
Pain Model ◽  
Therapeutic Efficiency ◽  
Neuropathic Pain Model

Spinal Cord Stimulation in a Mouse Chronic Neuropathic Pain Model

2007 ◽  
Vol 10 (4) ◽  
pp. 358-362 ◽  
Author(s):  
M. Truin ◽  
P. van Venrooij ◽  
V. Duysens ◽  
R. Deumens ◽  
M. van Kleef ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Chronic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model

167 SPINAL CORD STIMULATION IN A MOUSE CHRONIC NEUROPATHIC PAIN MODEL

2007 ◽  
Vol 11 (S1) ◽  
pp. S72-S72
Author(s):  
M. Truin ◽  
Y. Verboeket ◽  
W. Honig ◽  
R. Deumens ◽  
M. Kleef ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Chronic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model

scholarly journals The Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model

Life ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 69 ◽  
Author(s):  
Jacob M. Vigil ◽  
Marena A. Montera ◽  
Nathan S. Pentkowski ◽  
Jegason P. Diviant ◽  
Joaquin Orozco ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Infraorbital Nerve ◽  
Chronic Neuropathic Pain ◽  
Full Spectrum ◽  
Pain Model ◽  
Post Surgery ◽  
Whole Plant ◽  
Neuropathic Pain Model ◽  
Whisker Pad ◽  
Hemp Oil

Background: Few models exist that can control for placebo and expectancy effects commonly observed in clinical trials measuring ‘Cannabis’ pharmacodynamics. We used the Foramen Rotundum Inflammatory Constriction Trigeminal Infraorbital Nerve injury (FRICT-ION) model to measure the effect of “full-spectrum” whole plant extracted hemp oil on chronic neuropathic pain sensitivity in mice. Methods: Male BALBc mice were submitted to the FRICT-ION chronic neuropathic pain model with oral insertion through an incision in the buccal/cheek crease of 3 mm of chromic gut suture (4-0). The suture, wedged along the V2 trigeminal nerve branch, creates a continuous irritation that develops into secondary mechanical hypersensitivity on the snout. Von Frey filament stimuli on the mouse whisker pad was used to assess the mechanical pain threshold from 0–6 h following dosing among animals (n = 6) exposed to 5 μL of whole plant extracted hemp oil combined with a peanut butter vehicle (0.138 mg/kg), the vehicle alone (n = 3) 7 weeks post-surgery, or a naïve control condition (n = 3). Results: Mechanical allodynia was alleviated within 1 h (d = 2.50, p < 0.001) with a peak reversal effect at 4 h (d = 7.21, p < 0.001) and remained significant throughout the 6 h observation window. There was no threshold change on contralateral whisker pad after hemp oil administration, demonstrating the localization of anesthetic response to affected areas. Conclusion: Future research should focus on how whole plant extracted hemp oil affects multi-sensory and cognitive-attentional systems that process pain.

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