scholarly journals Circulating cell-free DNA concentration and DNase I activity of peripheral blood plasma change in case of pregnancy with intrauterine growth restriction compared to normal pregnancy

2017 ◽  
Vol 7 (4) ◽  
pp. 319-324 ◽  
Author(s):  
Elizaveta Ershova ◽  
Vasilina Sergeeva ◽  
Maria Klimenko ◽  
Kristina Avetisova ◽  
Peter Klimenko ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Peripheral Blood ◽  
Intrauterine Growth Restriction ◽  
Normal Pregnancy ◽  
Dnase I ◽  
Growth Restriction ◽  
Cell Free Dna ◽  
Intrauterine Growth ◽  
Free Dna ◽  
Peripheral Blood Plasma

scholarly journals Intrauterine Growth Restriction: Cytokine Profiles of Trophoblast Antigen-Stimulated Maternal Lymphocytes

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Raj Raghupathy ◽  
Majedah Al-Azemi ◽  
Fawaz Azizieh
Keyword(s):  
Inflammatory Cytokines ◽  
Peripheral Blood ◽  
Intrauterine Growth Restriction ◽  
Mononuclear Cells ◽  
Normal Pregnancy ◽  
Placental Insufficiency ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Anti Inflammatory ◽  
Ifnγ And Tnfα

Intrauterine growth restriction (IUGR) is an important perinatal syndrome that poses several serious short- and long-term effects. We studied cytokine production by maternal peripheral blood lymphocytes stimulated by trophoblast antigens. 36 women with a diagnosis of IUGR and 22 healthy women with normal fetal growth were inducted. Peripheral blood mononuclear cells were stimulated with trophoblast antigens and levels of the proinflammatory cytokines IL-6, IL-8, IL-12, IL-23, IFNγ, and TNFα and the anti-inflammatory cytokines IL-4, IL-10, and IL-13 were measured in culture supernatants by ELISA. IL-8 was produced at higher levels by blood cells of the IUGR group than normal pregnant women, while IL-13 was produced at lower levels. IL-8, IFNγ, and TNFα were higher in IUGR with placental insufficiency than in normal pregnancy. IL-12 levels were higher and IL-10 levels were lower in IUGR with placental insufficiency than in IUGR without placental insufficiency. We suggest that a stronger pro-inflammatory bias exists in IUGR as compared to normal pregnancy and in IUGR with placental insufficiency when compared to IUGR without placental insufficiency. Several ratios of proinflammatory to anti-inflammatory cytokines also support the existence of an inflammatory bias in IUGR.

scholarly journals Maternal total cell-free DNA in preeclampsia with and without intrauterine growth restriction

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Dong Wook Kwak ◽  
Shin Young Kim ◽  
Hyun Jin Kim ◽  
Ji Hyae Lim ◽  
Young-Han Kim ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Total Cell ◽  
Growth Restriction ◽  
Cell Free Dna ◽  
Intrauterine Growth ◽  
Free Dna

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complicated by preeclampsia or intrauterine growth restriction

2003 ◽  
Vol 89 (03) ◽  
pp. 486-492 ◽  
Author(s):  
Florence Bretelle ◽  
Florence Sabatier ◽  
Dominique Desprez ◽  
Laurence Camoin ◽  
Leila Grunebaum ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Vascular Complications ◽  
Annexin V ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Procoagulant Activity ◽  
Endothelial Microparticles ◽  
Intrauterine Growth ◽  
Cellular Marker ◽  
Circulating Microparticles

SummaryIn the present study, we explored the microparticles involved in the control of hemostatic equilibrium, i.e microparticles originating from platelet, endothelial cells and total MP defined as annexin V positive microparticles. Our aim was to analyze the level and procoagulant activity of these microparticles in normal pregnancy and pregnancies complicated with preeclampsia or isolated intrauterine growth restriction. We reported increased levels of platelet and endothelial microparticles in normal pregnancy compared to non pregnant healthy women. Number of annexin V microparticles was significantly increased together with their procoagulant activity. In pathological pregnancies, significant reduction in platelet microparticle number was found in preeclampsia. The procoagulant activity generated by the total annexin V MP was unchanged, suggesting that the microparticles remaining in the circulation were pro-coagulant. This study evidenced that microparticles constitute a cellular marker of a proinflammatory and procoagulant responses in normal pregnancy. In pregnancies with vascular complications, circulating MP with procoagulant potential may be part of the exacerbation of these responses.

Accuracy of Cerebroumblical Pulsatility Index Ratio in Intrauterine Growth Restriction in Third Trimester as a Predictor of Adverse Perinatal Outcome

2020 ◽  
pp. 5-11
Author(s):  
OJS Admin
Keyword(s):  
Intrauterine Growth Restriction ◽  
Perinatal Outcome ◽  
Pulsatility Index ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Third Trimester ◽  
Intrauterine Growth ◽  
Adverse Perinatal Outcome ◽  
High Incidence ◽  
Index Ratio

In pregnancy, good uteroplacental circulation is most important in good fetal growth and normal pregnancy outcome. Pregnancies, along with specific risk factors, have a high incidence of complications andcomplicating in intrauterine growth restriction (IUGR).

scholarly journals THE DIFFERENCE HUMAN LEUKOCYTE ANTIGEN-E (HLA-E) EXPRESSION AND NATURAL KILLER CELLS (NK CELLS) IN TROPHOBLAST BETWEEN INTRAUTERINE GROWTH RESTRICTION (IUGR) AND NORMAL PREGNANCY

2018 ◽  
Vol 3 (1) ◽  
pp. 15
Author(s):  
Soetrisno Soetrisno ◽  
Sri Sulistyowati ◽  
Supriyadi Hari Respati ◽  
Bambang Triono Cahyadi
Keyword(s):  
Human Leukocyte Antigen ◽  
Nk Cells ◽  
Intrauterine Growth Restriction ◽  
Human Leukocyte ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Immunohistochemical Method ◽  
P Value ◽  
Leukocyte Antigen ◽  
Intrauterine Growth

Background: Intrauterine growth restriction (IUGR) is still a major cause of perinatal morbidity and mortality. IUGR incidence ranged from 4.4 to 6.44% of pregnant women. Human Leukocyte Antigen - E and NK cells are thought to play an important role towards the process of IUGR.Objective: To determine aetiopathogenesis HLA-E expression and NK Cell in IUGR.Methods: An analytical observational study conducted through a cross-sectional approach. The research was conducted on March-October 2015 at the Obstetrics and Gynecology Department, Dr. Moewardi Hospital Surakarta and at of Laboratory of Pathology, Faculty of Medicine, Universitas Sebelas Maret Surakarta. Subjects who meet the inclusion and exclusion criteria consisted of 20 patients with IUGR and 20 normal pregnant patient. The researcher examined HLA-E Expression and NK cells in trophoblast using immunohistochemical method and statistical analysis using t test.Results: The average HLA-E expression in the trophoblast in IUGR group 17.80 ± 5.55, compared with normal pregnancy 66.23 ± 19.83, p value = 0.0001 (p <0.05). The average expression of NK cells in trophoblast in IUGR group 137.71 ± 28.09 compared with normal pregnancy 31.75 ± 14.77, p value = 0.0001 (p <0.05).Conclusion: HLA-E expression in normal pregnancy trophoblast is higher than pregnancies with IUGR. Expression of NK cells in pregnancy with IUGR is higher compared with normal pregnancy.

Sign in / Sign up

Export Citation Format

Share Document