scholarly journals Characterization of the T-cell subpopulations in the granulation tissues of chronic suppurative otitis media

2016 ◽  
Vol 4 (6) ◽  
pp. 694-698 ◽  
Author(s):  
BING WANG ◽  
YING CHENG ◽  
MIN XU
Keyword(s):  
T Cell ◽  
Otitis Media ◽  
Chronic Suppurative Otitis Media ◽  
Suppurative Otitis Media ◽  
Cell Subpopulations ◽  
T Cell Subpopulations

scholarly journals Functional and Clinical Characterization of Tumor-Infiltrating T Cell Subpopulations in Hepatocellular Carcinoma

2020 ◽  
Vol 11 ◽  
Author(s):  
Jianguo Li ◽  
Jin Zhou ◽  
Shuangshuang Kai ◽  
Can Wang ◽  
Daijun Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cell ◽  
Cell Subpopulations ◽  
T Cell Subpopulations

scholarly journals A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling

2018 ◽  
Author(s):  
Sebastian Scheer ◽  
Suzanne Ackloo ◽  
Tiago S. Medina ◽  
Matthieu Schapira ◽  
Fengling Li ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Chemical Probes ◽  
Th1 Cell ◽  
Regulatory Enzymes ◽  
Cell Subpopulations ◽  
T Cell Subpopulations ◽  
Protein Methyltransferases

SUMMARYProtein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs in cellular studies. Our collection provides inhibitors and antagonists that together modulate most of the key regulatory methylation marks on histones H3 and H4, providing an important resource for modulating cellular epigenomes. We describe a comprehensive and comparative characterization of the probe collection with respect to their potency, selectivity, and mode of inhibition. We demonstrate the utility of this collection in CD4+ T cell differentiation assays revealing the remarkable potential of individual probes to alter multiple T cell subpopulations with important implications for T cell-mediated processes such as inflammation and immuno-oncology. In particular, we demonstrate a role for DOT1L in limiting Th1 cell differentiation and maintaining lineage integrity.

scholarly journals Characterization of T-cell Subpopulations in Patients with Chronic Rhinosinusitis with Nasal Polyposis

2017 ◽  
Vol 8 (3) ◽  
pp. ar.2017.8.0214 ◽  
Author(s):  
Pascal Ickrath ◽  
Norbert Kleinsasser ◽  
Xin Ding ◽  
Christian Ginzkey ◽  
Niklas Beyersdorf ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Peripheral Blood ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Effector Memory ◽  
Forkhead Box ◽  
Cell Subpopulations ◽  
T Cell Subpopulations

Background There is an ongoing discussion concerning the potential origins of chronic rhinosinusitis with nasal polyposis (CRSwNP). Objective The aim of this study was to quantify subpopulations of T cells in peripheral blood and nasal polyps in CRSwNP to examine their influence on the etiology of this disease. Methods Tissue and blood samples were collected from 11 patients who underwent nasal sinus surgery, and these samples were analyzed by multicolor flow cytometry. Results There was a significantly lower frequency of CD4+ T-helper (Th) cells and a significantly higher frequency of CD8+ T cells among lymphocytes isolated from nasal polyps compared with peripheral blood mononuclear cells (PBMC). In both T-cell subpopulations, a shift mainly from naive T cells among peripheral blood lymphocytes toward an effector memory and terminally differentiated subtype predominance in nasal polyps was observed. Among CD4+ T cells, the frequencies of cluster of differentiation (CD) 45RA- Forkhead-Box-Protein P3high (FoxP3high) cytotoxic T-lymphocyte-associated Protein 4high (CTLA-4high) activated regulatory T (Treg) cells, and CD45RA- Forkhead-Box-Protein P3low (FoxP3low) memory T cells were significantly increased in nasal polyps compared with PBMC. Conclusion In this study, we presented a detailed characterization of CD4+ and CD8+ T-cell subpopulations in patients with CRSwNP. CD8+ T cells were more prominent in nasal polyps than in CD4+ T cells. Both nasal CD8+ T cells and CD4+ T cells predominantly had an effector memory phenotype. Among CD4+ T cells, activated Treg cells were increased in nasal polyps compared with PBMC. The data point toward a local regulation of T-cell composition within the microenvironment of nasal polyps, which might be further exploited in the future to develop novel immunotherapeutic strategies.

Characterization of CD31 expression in CD4+ and CD8+T cell subpopulations in chronic untreated HIV infection

2021 ◽  
Author(s):  
Olivia Briceño ◽  
Amy Peralta-Prado ◽  
Daniela Garrido-Rodríguez ◽  
Karla Romero-Mora ◽  
Monserrat Chávez-Torres ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
Cd8 T Cell ◽  
Cell Subpopulations ◽  
T Cell Subpopulations ◽  
Cd31 Expression

scholarly journals Characterization of T-Cell Subpopulations in Skin and Peripheral Blood of Patients with Cutaneous T-Cell Lymphomas and Benign Inflammatory Dermatoses

1983 ◽  
Vol 80 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Rein Willemze ◽  
Claire B. de Graaff-Reitsma ◽  
Jetske Cnossen ◽  
Willem A. van Vloten ◽  
Chris J.L.M. Meijer
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Inflammatory Dermatoses ◽  
T Cell Lymphomas ◽  
Cell Subpopulations ◽  
T Cell Subpopulations
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