Identification and characterization of rat T cell subpopulations expressing T cell receptors α/β and γ/δ

1990 ◽  
Vol 20 (2) ◽  
pp. 343-349 ◽  
Author(s):  
Alexandra Lawetzky ◽  
Georg Tiefenthaler ◽  
Ralph Kubo ◽  
Thomas Hünig
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Cell Receptors ◽  
Cell Subpopulations ◽  
T Cell Subpopulations ◽  
Identification And Characterization

Functional characterization of CD4+ T-cell receptors cross-reactive for SARS-CoV-2 and endemic coronaviruses

immuneACCESS ◽  
2021 ◽  
Author(s):  
AG Dykema ◽  
B Zhang ◽  
BA Woldmeskel ◽  
CC Garliss ◽  
LS Cheung ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Functional Characterization ◽  
Cd4 T Cell ◽  
Cell Receptors

Characterization of Autoantibodies Directed Against T Cell Receptors

1995 ◽  
pp. 223-229 ◽  
Author(s):  
Douglas F. Lake ◽  
William J. Landsperger ◽  
Ralph M. Bernstein ◽  
Samuel F. Schluter ◽  
John J. Marchalonis
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Cell Receptors

scholarly journals Functional and Clinical Characterization of Tumor-Infiltrating T Cell Subpopulations in Hepatocellular Carcinoma

2020 ◽  
Vol 11 ◽  
Author(s):  
Jianguo Li ◽  
Jin Zhou ◽  
Shuangshuang Kai ◽  
Can Wang ◽  
Daijun Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cell ◽  
Cell Subpopulations ◽  
T Cell Subpopulations

Characterization of T Cell Receptors Engineered for High Affinity Against Toxic Shock Syndrome Toxin-1

2005 ◽  
Vol 353 (2) ◽  
pp. 308-321 ◽  
Author(s):  
Rebecca A. Buonpane ◽  
Beenu Moza ◽  
Eric J. Sundberg ◽  
David M. Kranz
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Cell Receptors ◽  
High Affinity ◽  
Toxic Shock Syndrome Toxin

Generation and functional characterization of anti-clonotype antibodies to human T-cell receptors

1997 ◽  
Vol 210 (1) ◽  
pp. 51-64 ◽  
Author(s):  
Peter G.A Steenbakkers ◽  
Annemieke M H. Boots ◽  
Antonius W.M Rijnders
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Functional Characterization ◽  
Cell Receptors ◽  
Human T Cell

scholarly journals Characterization of a library of twenty HBV-specific MHC class II-restricted T cell receptors

2021 ◽  
Author(s):  
Sophia Schreiber ◽  
Melanie Honz ◽  
Weeda Mamozai ◽  
Peter Kurktschiev ◽  
Matthias Schiemann ◽  
...  
Keyword(s):  
T Cell ◽  
Mhc Class Ii ◽  
T Cell Receptors ◽  
Class Ii ◽  
Cell Receptors

scholarly journals A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling

2018 ◽  
Author(s):  
Sebastian Scheer ◽  
Suzanne Ackloo ◽  
Tiago S. Medina ◽  
Matthieu Schapira ◽  
Fengling Li ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
T Cell Differentiation ◽  
Chemical Probes ◽  
Th1 Cell ◽  
Regulatory Enzymes ◽  
Cell Subpopulations ◽  
T Cell Subpopulations ◽  
Protein Methyltransferases

SUMMARYProtein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs in cellular studies. Our collection provides inhibitors and antagonists that together modulate most of the key regulatory methylation marks on histones H3 and H4, providing an important resource for modulating cellular epigenomes. We describe a comprehensive and comparative characterization of the probe collection with respect to their potency, selectivity, and mode of inhibition. We demonstrate the utility of this collection in CD4+ T cell differentiation assays revealing the remarkable potential of individual probes to alter multiple T cell subpopulations with important implications for T cell-mediated processes such as inflammation and immuno-oncology. In particular, we demonstrate a role for DOT1L in limiting Th1 cell differentiation and maintaining lineage integrity.

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