scholarly journals Study of the in vitro cytotoxicity testing of medical devices

2015 ◽  
Vol 3 (5) ◽  
pp. 617-620 ◽  
Author(s):  
WEIJIA LI ◽  
JING ZHOU ◽  
YUYIN XU
Keyword(s):  
Medical Devices ◽  
In Vitro Cytotoxicity ◽  
Cytotoxicity Testing

Hyperthermia Increases the Cytotoxicity of Many Exogenous Compounds

2009 ◽  
Vol 43 (1) ◽  
pp. 73-79
Author(s):  
Anne D. Lucas ◽  
Sharon K. Lappalainen ◽  
Diane Wray-Cahen
Keyword(s):  
Cell Death ◽  
Medical Device ◽  
Medical Devices ◽  
Incubation Temperature ◽  
Fold Increase ◽  
Chemical Exposure ◽  
In Vitro Cytotoxicity ◽  
Cytotoxicity Testing ◽  
Exogenous Compounds

Abstract Cytotoxicity testing of extracts from medical device materials is typically conducted at 37°C. It may be more relevant to screen extracts from device materials for in vitro cytotoxicity at temperatures found in febrile patients. To address this, the cytotoxicity of selected chemicals, drugs, and medical device extracts was evaluated in vitro following incubation at normothermic (37°C) and hyperthermic (39°C) conditions. In L929 cells, the percentage of cell death increased from 2-fold to more than 4-fold after chemical exposure when cells were maintained at 39°C. Extracts of some medical devices and materials showed a 10-fold increase in cytotoxicity when cells were maintained at 39°C as compared to 37°C. For many of the substances in this study, exogenous compounds that are toxic at normothermic conditions (37°C) are more cytotoxic under hyperthermic conditions (39°C). The toxicity of compounds was more readily discernable at the higher incubation temperature, even at lower concentrations. In vitro cytotoxicity testing of chemicals and extracts at febrile temperatures can provide more sensitive and relevant biocompatibility tests than under normothermic conditions alone.

Erratum to “In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines” [Toxicology in Vitro 18 (2004) 365–376]

2004 ◽  
Vol 18 (5) ◽  
pp. 731
Author(s):  
S Nı́ Shúilleabháin ◽  
C Mothersill ◽  
D Sheehan ◽  
N.M O'Brien ◽  
J O'Halloran ◽  
...  
Keyword(s):  
Cell Lines ◽  
In Vitro Cytotoxicity ◽  
Metal Salts ◽  
Fish Cell ◽  
Fish Cell Lines ◽  
Zinc Metal ◽  
Cytotoxicity Testing

In vitro cytotoxicity testing of airborne formaldehyde collected in serum-free culture media

2005 ◽  
Vol 21 (5-6) ◽  
pp. 147-154 ◽  
Author(s):  
S Bakand ◽  
A Hayes ◽  
C Winder ◽  
C Khalil ◽  
B Markovic
Keyword(s):  
Culture Media ◽  
In Vitro Cytotoxicity ◽  
Serum Free ◽  
Cytotoxicity Testing

In vitro cytotoxicity testing of natural products using guinea-pig ear keratinocytes

1988 ◽  
Vol 2 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Ann Harris ◽  
Alison T. Keene ◽  
J. David Phillipson ◽  
David C. Warhurst
Keyword(s):  
Natural Products ◽  
Guinea Pig ◽  
In Vitro Cytotoxicity ◽  
Cytotoxicity Testing

In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines

2004 ◽  
Vol 18 (3) ◽  
pp. 365-376 ◽  
Author(s):  
S Nı́ Shúilleabháin ◽  
C Mothersill ◽  
D Sheehan ◽  
N.M O’Brien ◽  
J O’ Halloran ◽  
...  
Keyword(s):  
Cell Lines ◽  
In Vitro Cytotoxicity ◽  
Metal Salts ◽  
Fish Cell ◽  
Fish Cell Lines ◽  
Zinc Metal ◽  
Cytotoxicity Testing

scholarly journals National Cancer Institute pediatric preclinical testing program: Model description for in vitro cytotoxicity testing

2010 ◽  
Vol 56 (2) ◽  
pp. 239-249 ◽  
Author(s):  
Min H. Kang ◽  
Malcolm A. Smith ◽  
Christopher L. Morton ◽  
Nino Keshelava ◽  
Peter J. Houghton ◽  
...  
Keyword(s):  
National Cancer Institute ◽  
In Vitro Cytotoxicity ◽  
Model Description ◽  
Program Model ◽  
Preclinical Testing ◽  
Testing Program ◽  
Cytotoxicity Testing
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