scholarly journals Correlation of ABO Blood Groups and Rh Factor with The Severity of Generalized Chronic Periodontitis: Across Sectional Study in Riyadh, Saudi Arabia

2019 ◽  
Vol 7 (4) ◽  
pp. 617-622 ◽  
Author(s):  
Diana Mostafa ◽  
Essam I. Elkhatat ◽  
Pradeep Koppolu ◽  
Muna Mahgoub ◽  
Esam Dhaifullah ◽  
...  

BACKGROUND: The development of periodontal diseases depends on the presence of causative microorganisms, host immunity and risk factors. Although variability present among the types of periodontal diseases, all are represented to a shared interaction between host and bacteria. ABO blood groups are the most investigated erythrocyte antigen system. However, limited investigations have been conducted to explore the alliance between ABO blood groups and periodontal diseases. AIM: Our purpose was to explore any possible association between the severity of chronic periodontitis with ABO blood groups and Rh factor. METHODS: A cross-sectional study was carried out on 205 patients out of 1126 generalised chronic periodontitis patients (GCP) who were referred to Al-Farabi Colleges, Riyadh, Saudi Arabia. They were categorized into; group I (mild), group II (moderate) and group III (sever). RESULTS: The patients with blood group O were at a greater risk to develop GCP irrespective of its severity, followed by those with blood group A, B, and AB. The dispensation of the Rh factor in all groups exhibited a significantly greater distribution of Rh positive. CONCLUSION: Genetic factors such as ABO blood group antigens may act as a risk influencer that affects the progression and severity of the chronic periodontitis.

2019 ◽  
Vol 26 (07) ◽  
pp. 1167-1171
Author(s):  
Sabeen Fatima ◽  
Mona Aziz ◽  
Sindhu Rehman ◽  
Maliha Asif ◽  
Naseem Akhtar ◽  
...  

Introduction: Among the complications of blood transfusion, Hemolytic transfusion reactions (HTRs) and Hemolytic disease of the newborn (HDN) are particularly important. Literature reports frequency of HTRs and related mortality up to 1/76,000 and 1/1.8 million units transfused respectively. These hemolytic reactions are caused by incompatibility between the donor and recipient blood and in cases of HDN, due to feto-maternal incompatibility due to maternal antibodies attacking the fetal red cells. Anti-K antibody is the most common antibody encountered in blood banks after the ABO and Rh antibodies. So routine screening and matching of these blood antigens along with ABO and Rh can further reduce the risk of HTRs and HDN. Existing literature on Kell blood system reports varying frequency of K and k antigens among various populations. Objectives: The objectives of this study were to determine the prevalence of Kell blood group antigens in the blood donor population at Shaikh Zayed and Jinnah Hospitals Lahore and the association of Kell blood group antigens with different ABO blood groups of Lahore population. Study Design: It is a descriptive cross-sectional study. Setting: Research was conducted at the Blood banks of Sheikh Zayed Hospital, Lahore and Jinnah Hospital, Lahore. Period: 6 months after the approval of synopsis from 15/06/2015 to 15/12/2015. Material and Methods: This study included 192 donors; 96 from Sheikh Zayed Hospital, Lahore and 96 from Jinnah Hospital, Lahore. A written informed consent was taken from every donor. Kell blood group antigens K and k were determined. Results: There were 192 donors, 96 each from Shaikh Zayed Hospital, Lahore and Jinnah Hospital, Lahore. Out of these donors 186 (96.9%) were males and 6 (3.1%) were females. The most frequent ABO blood group antigen observed was B, which was seen in 82 (42.7%) donors, followed by O in 68 (35.4%), A in 36 (18.8%) and AB in 06 (3.1%) donors. Kell antigen k was found in 185 (96.3%) donors while K was found in 07 (3.6%) donors. When stratified, there was no statistically significant difference in the frequency of Kell antigens between genders (p=0.08) and ABO blood groups (0.09). The frequency of k antigen was higher among those with blood group B (43.2% vs. 17.8%) as compared to A, and the frequency of K antigen was higher among those with blood group A (42.8% vs. 28.5%) as compared to B, however, this was statistically insignificant. Conclusion: The frequency of k was observed to be 96.3%. It was higher in donors with antigen B while the frequency of K was found to be 3.6% and it was higher in donors with antigen A.


2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Elaina Pasangha ◽  
Arkadeep Dhali ◽  
Christopher D'Souza ◽  
Soumya Umesh

Background: Blood groups are inherited traits that affect the susceptibility/severity of a disease. A clear relationship between coronavirus disease 2019 (COVID-19) and ABO blood groups is yet to be established in the Indian population. This study aimed to demonstrate an association of the distribution and severity of COVID-19 with ABO blood groups. Methods: A cross-sectional study was conducted after obtaining ethics approval (IEC 207/20) among hospitalized patients using in-patient records and analyzed on SPSS-25. Chi-square tests were used for the analysis of categorical data and independent sample t-test/Mann–Whitney U tests were used for continuous data. Results: The B blood group had the highest prevalence among COVID-19-positive patients. The AB blood group was significantly associated with acute respiratory distress syndrome (ARDS) (p = 0.03), sepsis (p = 0.02), and septic shock (p = 0.02). The O blood group was associated with significantly lower rates of lymphopenia and leucocytosis. However, no significant clinical association was seen in the O blood group. Conclusion: This study has demonstrated that blood groups have a similar distribution among patients hospitalized with COVID-19 in the South Indian population. Additionally, it preludes to a possible association between the AB blood group and ARDS, sepsis, and septic shock. Further studies having a larger representation of AB blood groups, especially in patients hospitalized for critical COVID-19, with adjustment for possible covariates, are warranted to provide a reliable estimate of the risk in the South Indian population.


2021 ◽  
Vol 4 (2) ◽  
pp. 132-144
Author(s):  
Nikolaos Chrysanthakopoulos

Introduction: Periodontal disease (PD) development has been associated with the presence of causative microorganisms, host immunity and risk factors, whereas the types of periodontal diseases are characterized by interactions between host and bacteria. Moreover, ABO blood groups are the most investigated erythrocyte antigen system. However, a small number of researches have been focused on the possible associations between ABO blood groups and periodontal diseases. Methods: A cross-sectional, epidemiological study was carried out on 854 individuals, 404 males and 450 females, aged 45 to 77. The study sample was interviewed and underwent an oral and dental clinical examination. The assessment of the possible associations between several indices of PD, such as Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL) and Bleeding on Probing (BOP) as dependent variables and ABO blood groups A, B, AB, and O as independent ones was carried out by using a multiple regression analysis model. Results: Individuals with blood group A [OR= 2.94, 95% CI = 1.27-3.96] and B [OR= 2.66, 95% CI = 1.11-3.87] were significantly associated with the risk of developing deeper periodontal pockets (PPD) and worse values of attachment loss (CAL) [OR= 2.42, 95% CI= 1.37-3.85] and [OR= 2.31,95% CI=1.25-3.68], respectively. However, no significant associations were recorded between ABO blood groups and BOP [OR= 1.04, 95% CI= 0.92-1.18]. Conclusion: A significant association was revealed between A and B blood groups and deeper periodontal pockets and worse attachment loss, whereas no associations were observed between ABO blood groups and bleeding of probing.


PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249252
Author(s):  
Reaz Mahmud ◽  
Mohammad Aftab Rassel ◽  
Farhana Binte Monayem ◽  
S. K. Jakaria Been Sayeed ◽  
Md Shahidul Islam ◽  
...  

Background Globally, studies have shown conflicting results regarding the association of blood groups with SARS CoV-2 infection. Objective To observe the association between ABO blood groups and the presentation and outcomes of confirmed COVID-19 cases. Design, setting, and participants This was a prospective cohort study of patients with mild-to-moderately severe COVID-19 infections who presented in the COVID-19 unit of Dhaka Medical College Hospital and were enrolled between 01 June and 25 August, 2020. Patients were followed up for at least 30 days after disease onset. We grouped participants with A-positive and A-negative blood groups into group I and participants with other blood groups into group II. Results The cohort included 438 patients; 52 patients were lost to follow-up, five died, and 381 completed the study. The prevalence of blood group A [144 (32.9%)] was significantly higher among COVID-19 patients than in the general population (p < 0.001). The presenting age [mean (SD)] of group I [42.1 (14.5)] was higher than that of group II [38.8 (12.4), p = 0.014]. Sex (p = 0.23) and co-morbidity (hypertension, p = 0.34; diabetes, p = 0.13) did not differ between the patients in groups I and II. No differences were observed regarding important presenting symptoms, including fever (p = 0.72), cough (p = 0.69), and respiratory distress (p = 0.09). There was no significant difference in the median duration of symptoms in the two group (12 days), and conversion to the next level of severity was observed in 26 (20.6%) and 36 patients (13.8%) in group I and II, respectively. However, persistent positivity of RT-PCR at 14 days of initial positivity was more frequent among the patients in group I [24 (19%)] than among those in group II [29 (11.1%)]. Conclusions The prevalence of blood group A was higher among COVID-19 patients. Although ABO blood groups were not associated with the presentation or recovery period of COVID-19, patients with blood group A had delayed seroconversion.


1969 ◽  
Vol 3 (2) ◽  
pp. 318-322
Author(s):  
MUHAMMAD KHALID ◽  
NAILA ASLAM ◽  
MUHAMMAD SIYAR ◽  
RASHID AHMAD

OBJECTIVE: To find out the distribution of ABO and Rh (D) blood groups among blood donors in districtMardan and to help transfusion services in the area.STUDY DESIGN: Cross sectional descriptive study.MATERIALS AND METHODS: The study was conducted in DHQ Hospital Mardan from 1st January2012 to 31st December 2012. A total of 2893 healthy adult, blood donors (both volunteer and directed) fromdistrict Mardan were included. Two ml of blood anti-coagulated with EDTA was taken and both ABO andRh (D) blood groups were determined using commercially available anti-sera of Biolaboratories. Thedistribution ofABO and Rh blood groups in the local community were then calculated.RESULTS: Among ABO blood groups “ B” (27.97%) was the most prevalent, followed by “0” (27.93%),“ A” (24.75%) and “ AB” (19.36%). Group Rh positive (94.30%) was more prevalent than Rh negative(5.70%). Similarly 0+ve (26.65%) was most frequent followed by B+ve (26.17%), A+ve (23.16%), AB+ve(18.32%), B've(1.80%),Ave(l.59%),O ve( 1.28%) and ABve( 1.04%).CONCLUSION: Blood group 'B' was most frequent among the ABO blood groups and Rh (D) positiveamong Rh blood groups while0+vewas the most frequent blood group in the study population.KEYWORDS: ABO Blood grouping, Rh (D) blood grouping, Mardan.


2017 ◽  
Vol 13 (4) ◽  
pp. 372-377
Author(s):  
Nilu Manandhar ◽  
Kushal Bhattarai

Background & Objectives: The various ABO and Rh blood groups with different distribution frequencies in the general population have been found to be associated with different diseases, most notably gastritis. Many studies have claimed Rh groups to be indifferent to such association. Nonetheless, ABO group is found to linked with chronic gastritis. The aim of this study was to estimate the frequencies of ABO and Rh blood groups and the gastritis amongst the first and second year undergraduate medical and dental students; and to study their relationships. Materials & Methods: In a descriptive, cross-sectional study, 247 study participants were enrolled. After procuring clearance from the institutional review committee and the informed and written consent from the study participants, data collection was done on the variables, year of study (first or second year), gender, blood groups (ABO and Rh) and history of gastritis (present or absent).Results: Blood group O was the commonest (n=99; 40.1%) followed by group B (n=77; 31.2%). Similarly, 239 (96.8%) participants were Rh-positive as compared to 8 (3.2%) Rh-negative. Interestingly, 46 (18.6%) of the participants reported positive history of gastritis. Participants with blood group O had the greatest odds (OR=1.64) of having history of gastritis compared with those with other blood groups combined. Distribution of study participants based on gender and history of gastritis in either systems of blood grouping shoed no significant difference in their proportions (p>0.05). Conclusion: In light of the above findings, further longitudinal studies can be designed to better asses the relationship.


2021 ◽  
Vol 14 (02) ◽  
pp. 1065-1076
Author(s):  
Osama M Alshehri ◽  
Mohammed H Nahari ◽  
Elhashimi E Hassan ◽  
Musab F Alqahtani ◽  
Turki H Awaji

The knowledge of Red blood cells polymorphism and blood group antigens prevalence at the local and regional levels is necessary for safe blood transfusion services. This study was aimed to estimate the prevalence of significant blood group phenotypes like ABO, Rh, and Kell among the Najran people of Saudi Arabia. The transfusion transmittable infection (TTI) rate and blood abnormalities among various blood types were assessed to ensure safe blood transfusion. ABO and Rh blood prevalence (n=970) and Rh phenotype polymorphism were estimated in over 531 unrelated donors. The blood samples were screened for certain TTIs like AHBC- Anti-hepatitis B core, HTLV-1- human T-lymphotropic virus type I, HCV- hepatitis C virus, HBsAg- Hepatitis B antigen, HIV- Human immunodeficiency virus, SIC- Sickle cell, MP- Malaria parasite, and SYP- Syphilis. The selected samples were also observed for blood abnormalities by performing a complete blood count (CBC). Out of 970 subjects, 966 were males, and only 4 were females. The O>A>B>AB blood groups were identified with 46.89, 29.3, 9.1, and 2.38% prevalence among Rh-positive phenotype. While in the Rh system, 87.6% and 12.3% of Rh positive and Rh negative was observed. Among 953 samples, the prevalence of seropositive donors was approximately 5.66%. The screening showed about 5.036, 0.104, 0.314, 0.209, 2.18, 0.104, and 0.209% positivity for AHBC, HCV, HBsAg, HIV, SIC, MP, and SYP respectively. Results found that the frequency of D, C, E, c, and e were 99.9%, 67.98, 25.8, 77.9, 98.49%, respectively, in over 531 subjects. The e allele was more prevalent in Najran city. After observing the variations in the CBC parameters among the donors, it was perceived that about 28.78, 99.9, 29.41, and 31.6% of blood abnormalities were noticed for O, AB, B, and A blood groups, respectively. For blood banks and transfusion services, which play a significant role in the medical care of the patient, awareness of the distribution of the blood group is essential. Increasing consistency of blood donation programs would improve both donor satisfaction and motivation for potential donations of blood in near future.


2020 ◽  
Vol 24 (2) ◽  
pp. 103-107
Author(s):  
Imran Iftikhar ◽  
Hamid Sharif Khan ◽  
Adeel Ur Rehman

OBJECTIVE: To determine the frequency of ABO blood groups among patients with acute myocardial infarction in the Pakistani population STUDY DESIGN: Cross-sectional study PLACE AND DURATION OF STUDY : Department of Interventional Cardiology, Rawalpindi Institute of Cardiology, Rawalpindi, from May 2015 to November 2015. METHODOLOGY: A total of 250 subjects with acute myocardial infarction were included in the study. The study was explained to the patients and informed consent taken. All patients underwent 12 lead electrocardiography using Mortara instrument ELI 250 and were analyzed by a single trained reader unaware of the patients’ blood group. Cardiac troponin levels were assessed at least three hours after the onset of symptoms. The ABO blood group was assessed by using the standard slide agglutination method in the hospital pathology laboratory and verified by the principal investigator. The data was collected on a pre-tested questionnaire by the investigator after taking informed consent from the patient. RESULTS: In our study, the mean age of patients was 57.3 years. 36.4% were between 18-50 years of age while 63.6%were between 51-80 years of age. 79.2% were male and 20.8% were females. Frequency of ABO blood groups among patients with acute myocardial infarction in our study population was recorded as 28.8% with O +ve , 26% with B+ve, 18.4% with A+ve, 13.2% with AB +ve, 5.6% with A-ve, 4.4% with B-ve, 3.2% with O-ve and 0.4% with AB -ve CONCLUSION: We concluded that the frequency of acute myocardial infarction in our population is higher among patients having blood group O+ve followed by B+ve blood group.


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