scholarly journals Clinical Aspects and Treatment of Pityriasis Lichenoides Et Varioliformis Acuta: A Retrospective Vietnamese Study

2019 ◽  
Vol 7 (2) ◽  
pp. 198-199 ◽  
Author(s):  
Thuong Nguyen Van ◽  
Tuyen Nguyen Thi ◽  
Doanh Le Huu ◽  
Nghi Dinh Huu ◽  
Mai Le Thi ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Immunosuppressive Drugs ◽  
Clinical Aspects ◽  
Female Ratio ◽  
Pityriasis Lichenoides ◽  
Hospitalised Patients ◽  
Uncommon Condition ◽  
The Common ◽  
Systemic Antibiotics ◽  
Male To Female

BACKGROUND: Pityriasis lichenoides et varioliformis acuta (PLEVA) is an uncommon condition which presents acutely with papulo-vesicles that may develop necrotic, ulcerative, or hemorrhagic changes. AIM: We studied clinical, and treatment characteristics of PLEVA hospitalised patients at our hospital from September 2009 to December 2014. METHODS: The records of 15 PLEVA patients were retrospectively reviewed. RESULTS: The median age of onset was 21.8 ± 18.81 (from 1 to 68), male to female ratio was 2/1. The common area of onset was trunk (60.0%) and extremities (33.3%). Clinical features were purpuric papules (100%), hemorrhagic crusted papules (46.7%), pustular purpuric papules (40%), and necrotic ulcerating lesions (13.3%). CONCLUSION: All patients were received systemic antibiotics (macrolides: 53.3%, others: 46.7%), 2 patients were added immunosuppressive drugs. A 1-year-old patient died, others had a good response.

scholarly journals Clinical and Immunohistochemical Features of Oral Angioleiomyoma: A Comprehensive Review of the Literature and Report of a Case in a Young Patient

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Amerigo Giudice ◽  
Francesco Bennardo ◽  
Caterina Buffone ◽  
Ylenia Brancaccio ◽  
Francesca Maria Plutino ◽  
...  
Keyword(s):  
English Language ◽  
Immunohistochemical Analysis ◽  
Surgical Excision ◽  
Clinical Aspects ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
Presumptive Diagnosis ◽  
Female Ratio ◽  
S 100 ◽  
Male To Female

Angioleiomyoma (AL) is an uncommon benign soft tissue neoplasia arising from the tunica media of the smooth muscle cells. AL appears as a solitary and slow-growing mass and seldom is observed in oral tissues. We reported a rare case of AL involving the cheek of a 17-year-old young woman. A review of the English-language literature was performed entering the keywords “angioleiomyoma” and “oral” in the search fields of PubMed. 70 results were identified. Excluded were cases that were not in the oral cavity or not compatible with the AL diagnosis or report lacking immunohistochemical analysis. According to the exclusion criteria, we selected 30 studies that included 63 cases of AL. The results of the review showed an average age of 42.97 years with a prevalence between the fourth and fifth decade of life with a male-to-female ratio of 1.95 : 1. The most affected sites were palate, buccal mucosa of the cheek, lip, tongue, and gingiva. Surgical excision was the treatment of choice, and diagnosis was possible through histopathological and immunohistochemical analysis. SMA, vimentin, CD34, desmin, and S-100 were the most common markers to guide the histopathological diagnosis of oral AL. In conclusion, oral AL is a rare entity, especially in adolescence as in the reported case of AL of the cheek in a 17-year-old woman. The clinical aspects of AL did not allow clinicians to make a correct presumptive diagnosis. A scrupulous histopathological analysis and immunohistochemical examinations are fundamental to differentiate AL from other lesions.

scholarly journals Preoperative Factors Associated with Postoperative Diabetes Insipidus after Transsphenoidal Pituitary Adenectomy

2019 ◽  
Vol 16 (3) ◽  
pp. 55-57
Author(s):  
Sagar Koirala ◽  
Suresh Bishokarma ◽  
Dinesh Nath Gongal
Keyword(s):  
Pituitary Adenomas ◽  
Functional Type ◽  
Gold Standard Method ◽  
Female Ratio ◽  
Male Preponderance ◽  
Patient Size ◽  
Onset Of Diabetes ◽  
The Common ◽  
Male To Female ◽  
Preoperative Factors

Transsphenoidal pituitary adenectomy is the gold standard method of treatment of pituitaryadenomas. Post-operative diabetes insipid sis one of the common complication of this procedure. In this study we have analyzed pre-operative factors that may be associated with onset of diabetes insipid us following this procedure. A retrospective study of five years was conducted in a tertiary neurosurgical center. Histologically proven cases of pituitary adenomas who underwent transsphenoidalpituitary adenectomy were included in the study. Age and sex of the patients along with size and functional type of tumor were analyzed to see if they predicted the occurrence of diabetesinsipidus post-operatively. Out of 49 cases who underwent transsphenoidalpituitary surgery, 46 cases were proven to be pituitary adenomas histologically. There was male preponderance with male to female ratio of2:1. Age ranged from 15 to 72 with median age of 37 years. Nonfunctional, prolactinomas and growth hormone secreting tumors, were 25, 16and 4 in number. Median size of the tumor was2.35 in largest diameter. Out of these patients13 (28%) patients developed diabetes insipid us. Age, sex of the patient, size of the tumor and functional type of the tumor did not predict the incidence. Age, sex of the patient, size of the tumor and functional type of the tumor do not predict the incidence of diabetes insipid us post-operatively in patients undergoing transsphenoidal pituitaryadenectomy.

scholarly journals Paracoccidioidomycosis in the state of Maranhão, Brazil: geographical and clinical aspects

2012 ◽  
Vol 45 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Wilma Batista de Matos ◽  
Gisele Maria Campelo dos Santos ◽  
Vitor Emmanuel Bouças da Silva ◽  
Eloísa da Graça do Rosário Gonçalves ◽  
Antonio Rafael da Silva
Keyword(s):  
Rural Areas ◽  
Case Series ◽  
The State ◽  
Clinical Aspects ◽  
Direct Examination ◽  
Female Ratio ◽  
Central Regions ◽  
Clinical Description ◽  
Two Stages ◽  
Male To Female

INTRODUCTION: The study aimed to show the situation of paracoccidioidomycosis in the state of Maranhão, Brazil. METHODS: This study is a descriptive case series developed in two stages. First, a survey of cases originating from the state of Maranhão at the Instituto de Doenças Tropicais Natan Portela, Piauí (IDTNP) from 1997 to 2007, and second, the clinical description of 29 cases diagnosed in the Centro de Referências em Doenças Infecciosas e Parasitárias, Maranhão (CREDIP) from 2004 to 2010. RESULTS: Two hundred and sixteen cases have been cataloged at the IDTNP. West, east, and central regions of the state of Maranhão recorded 90.3% of cases proving to be important areas for study. The western region, with a prevalence of 10.8/100,000 inhabitants, has a significantly higher proportion of cases than the northern, southern, and eastern regions (p < 0.05). The occurrence was higher in men with 89.3% of cases, and the male-to-female ratio was 8.4:1. The majority of patients were older than 20 years, lived in rural areas, and had farming or soil management as main occupation (73.8%). At CREDIP, 29 cases were diagnosed, of which 26 (89.6%) had multifocal manifestations. Mucous tissues were involved more (75.8%) frequently, followed by lymph nodes, skin, and lungs with 65.5%, 39% and 37.9 %, respectively. The diagnosis was made by combining direct examination, culture, and histopathology. CONCLUSIONS: The study shows the geographical distribution and the epidemiological and clinical aspects of paracoccidioidomycosis, revealing the significance of the disease to the state of Maranhão.

scholarly journals Frequency of Thyrotoxicosis in Patient with One Sided Exophthalmos

2020 ◽  
Vol 8 (2) ◽  
pp. 81-84
Author(s):  
Tahreem Zafar ◽  
Shumaila Perveen ◽  
Nisar Khan ◽  
Salman Khan ◽  
Tahseen Ahmed
Keyword(s):  
Sinus Thrombosis ◽  
Case Series ◽  
Posterior Segment ◽  
Medical Department ◽  
Female Ratio ◽  
Duration Of Illness ◽  
Associated Symptoms ◽  
The Common ◽  
Male To Female ◽  
Orbital Rim

Background: Thyroid associated Opthalmo-pathy is a condition of lid retraction causing a staring appearance. This occurs in any form of thyrotoxicosis as a result of sympathetic overactivity.Exophthalmos is the forward protrusion of eye ball beyond the orbital rim. Material & Methods: This case series was observed in medical department Mufti Mehmood Teaching Hospital DIKhan, Pakistan over a period of eight months from February 2018 to September 2018. Detailed history with reference of duration of illness, mode of onset, progression and associated symptoms like fever, pain, diplopia and loss of vision was taken. Complete examination of orbit, eyelid, anterior and posterior segment was done. Routine Investigations along with special diagnostic tests like TFTs and MRI were performed to aid etiological diagnosis. Results: A total 47 patients were observed during this study period. Out of these 20 (21.27%) were male and 27 (57.44%) were female with male to female ratio 1:1.35 with mean age of 32 years. Out of 47 patients30 (63.82%) patients were having thyrotoxicosis as a cause of exophthalmos, 10(21.27%) were having retrobulbartumour, 5(10.63%) patients were with cavernous sinus thrombosis and 2(4.25%) patients were having idiopathic cause of exophthalmos. Conclusion: Thyrotoxicosis is the common cause of one sided exophthalmos and should be considered in all patients with one sided exophthalmos.

scholarly journals Benign fibro-osseous lesions of the jaws: a clinicopathologic study of 98 Tanzanian patients

2019 ◽  
Vol 25 (4) ◽  
pp. 38
Author(s):  
Ntokozo C. Dube ◽  
Jeremiah Robert Moshy ◽  
Edda A. Vuhahula ◽  
Karpal Singh Sohal
Keyword(s):  
Fibrous Tissue ◽  
Giant Cells ◽  
Ossifying Fibroma ◽  
Female Ratio ◽  
Histological Features ◽  
Fibrous Stroma ◽  
Clinicopathologic Study ◽  
Woven Bone ◽  
The Common ◽  
Male To Female

Introduction: The benign fibro-osseous lesions (BFOL) are characterized by replacement of the normal bone by cellular fibrous tissue containing various forms of ossification. They encompass common clinical, radiologic and histopathological features and hence pose considerable diagnostic and therapeutic challenges to clinicians and pathologists. Objective: To analyze the clinico-pathological and radiological features of BFOLs of the jaws in patients treated at Muhimbili National Hospital, Tanzania. Material and methods: A retrospective study of files of patients who were diagnosed with BFOLs from January 2011 to December 2013 was done. The collected information included data on demographic characteristics, the duration of the lesion, location of the lesion, presence of swelling, associated symptoms and reported radiological and histological features. Results: A total of 98 patient's records were retrieved. There was a predominance of females (59, 60.2%), with a male to female ratio of 1:1.5. The patient's age at presentation ranged from 5 years to 75 years with a mean age of 29.81 ± 15.28 years. Four types of BFOLs were encountered. Ossifying fibroma were the most frequent (61.2%), followed by fibrous dysplasia (19.4%). Maxilla was more affected than the mandible. Majority (>70%) of the BFOLs were radio-opaque. The common histological features in all four types of BFOL included presence of: woven bone in fibrous stroma, giant cells, loose collagen and foci of hemorrhage. Conclusion: In this sample, BFOLs, were slightly more prevalent in females than males, affecting individuals below 40 years at large. They showed several overlapping clinical, radiological and histological features; thus a combination of different modalities seems necessary for an accurate diagnosis.

scholarly journals Clinicopathological Profile of Rhabdomyosarcoma in Children

2012 ◽  
Vol 30 (3) ◽  
pp. 132-136
Author(s):  
Umme Habiba Begum ◽  
Afiqul Islam
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Mass Lesion ◽  
Female Ratio ◽  
Head And Neck Region ◽  
Clinicopathological Profile ◽  
Common Clinical Presentation ◽  
The Common ◽  
Medical University ◽  
Male To Female

Objectives: To describe the clinical profile as well as  histopathological sub-types of Rhabdomyosarcoma in  children.Methods: A hospital base prospective observational study  was conducted among 20 diagnosed cases of  Rhabdomyosarcoma in children, those attending in  Hemato-Oncology department of Bangabandhu Sheikh  Mujib Medical University (BSMMU), Dhaka in the period  between January to December 2009.Results: The peak incidence of Rhabdomyosarcoma was  in 1-5 years of age group (n=9, 45%) with mean age 6.83  years with male to female ratio 5.66:1. The common sites  of primary tumor was in head and neck region (40%, n=08),  followed by genito-urinary tract, 30% (n=06), extremities  20% (n=04), trunk 10% (n=02). The most common clinical  presentation was mass lesion 100% (n=20), followed by local  pain 25% (n=05), urinary obstructions 15% (n=03)  dysphagia, chronic otorrhea, dysuria, haematuria, and  proptoses were 10% each (n=02, each); The histological  sub-types were Embryonal 60% (n=12), alveolar 30% (n=6),  and Botryoid 10% (n=02); Of Embryonal variety in head  and neck region 58.33% (n=7), and Genito-urinary sites  41.67% (n=5); of Alveolar variety in trunk 66.67% (n=4),  and in extremities33.33% (n=2), of Botryoid sub-type  frequency was equal in head - neck region and genitourinary  site 50% each (n=1).Conclusion: Children with Rhabdomyosarcoma presented mostly in 1 to 5 years of age, with mass lesion (100%),  predominantly in head and neck region (40%) and the  commonest histological sub-type was Embryonal variety  (60%). DOI: http://dx.doi.org/10.3329/jbcps.v30i3.12461 J Bangladesh Coll Phys Surg 2012; 30: 132-136

scholarly journals Common Site of Urinary Calculi in Kidney, Ureter and Urinary Bladder Region: Jos Experience

2019 ◽  
Vol 7 (10) ◽  
Author(s):  
Samuel Moses Danjem ◽  
Salaam AJ ◽  
Kolade- Yunusa HO ◽  
Shuaibu SI
Keyword(s):  
Urinary Bladder ◽  
Urinary Calculi ◽  
Renal Stones ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Common Location ◽  
The Common ◽  
Male To Female

Objective: To determine the common location of calculus along the urinary tract using CT scan.  Methods: This cross sectional study was conducted using CT from November 2016 to September 2018, in a tertiary hospital in Jos, Nigeria. The CT images acquired from this period were evaluated and 50 patients were positive for urolithiasis. The data was subjected to statistical analysis based on age, gender and calculus location. Results: Out of the 50 patients with calculi, 34 were males and 16 were females with a male to female ratio of 2.13:1. 137 urinary calculi were documented in which 90 were in males and 47 in the female patients. Highest occurrence of calculi was seen in age group 31-40 years (34.0%). 112(82%) were renal stones, 12(9%) were ureteric stones, 8(6%) were found in pelvi-ureteric junction (PUJ), 3(2%) were in the vesico-ureteric junction (VUJ), 2(1%) were in the urinary bladder and none in the urethra. Conclusion: Kidney stones are the most common followed by the ureter, the pelvi-ureteric junction, the vesico-ureteric junction and the bladder.  

scholarly journals Dermoscopic Patterns in Juvenile Xanthogranuloma Based on the Histological Classification

2021 ◽  
Vol 7 ◽  
Author(s):  
Jiaosheng Xu ◽  
Lin Ma
Keyword(s):  
Late Stage ◽  
Age Of Onset ◽  
Early Stage ◽  
Case Series ◽  
Juvenile Xanthogranuloma ◽  
Histopathological Diagnosis ◽  
Proliferative Index ◽  
Female Ratio ◽  
Large Case Series ◽  
Male To Female

Background: Several dermoscopic features of juvenile xanthogranuloma (JXG) have been previously described in single cases or small case series and need to be further verified in a large sample.Objective: We aimed to investigate the dermoscopic patterns of JXG in a large case series and the correlations of these with clinical features of different histopathological subtypes of JXG.Methods: Patients who underwent dermoscopic evaluation and had a histopathological diagnosis of JXG were recruited. Histological findings, including stage and Ki67 proliferative index and the dermoscopic features of each lesion were recorded.Results: Forty-one patients with JXG were included. The male to female ratio was 1.28: 1 and the median age of onset was 11 months (range: 0–95 months). Fourteen lesions were histologically categorized in the early stage, 17 in the developed stage, and 10 in the late stage. The “setting sun” pattern was observed in 35 lesions (85.4%) and “clouds” of paler yellow areas in 26 lesions (63.4%). The frequency of the “setting sun” pattern was higher in the early and developed stages (30/31) than in the late stage (5/10) (P = 0.002), while that of “clouds” of paler yellow areas was not significantly different between each stage. Branched linear vessels were detected in the early (11/14) and developed stage (6/17), but not in the late stage. The mean Ki67 index of the lesions with linear vessels was 11.8% (range: 2–40%), which was higher than that of lesions without linear vessels (mean index: 5%, range: 1–30%) (P = 0.005). The pigment network and whitish areas were only detected in 6 and 5 lesions in the late stage, respectively. The whitish areas presented either as streak or stellate shape. The pigment network exhibited either in a centric or a peripheral pattern.Conclusions: The “setting sun” pattern is the characteristic dermoscopic features of JXG in the early and developed stages, while whitish areas and pigment network are the characteristic patterns in the late stage. Linear vessels present as branched patterns and mostly occur in the early stage with a high proliferative index, indicating rapid growth. The whitish areas and pigment network may present in various patterns. Dermoscopy is a useful adjunctive tool in the diagnosis and staging of JXG.

scholarly journals Immunosuppressive Drugs and Kidney Post-transplant Diabetes Mellitus

2019 ◽  
Vol 4 (2) ◽  
pp. 50-56
Author(s):  
Ismael Bilal Ismael ◽  
Sarhang Hasan Azeez
Keyword(s):  
Diabetes Mellitus ◽  
Renal Transplantation ◽  
Creatinine Level ◽  
Immunosuppressive Drugs ◽  
Female Ratio ◽  
Random Blood Sugar ◽  
Post Transplant ◽  
Wbc Count ◽  
Male To Female

Background: As the rate of renal transplantation increases, more immunosuppressive drugs such as cyclosporine A (CsA) are consumed, particularly during the early months following transplantation, leading to post-transplant diabetes mellitus (PTDM) which can cause death. Objective: The present study examined the role of CsA in causing PTDM and other effective factors among patients with chronic kidney disease (CKD) who had undergone renal replacement therapy. Methods: The present investigation was a quantitative case-control study carried out on 30 CKD patients who had undergone renal transplantation and 30 healthy individuals. A questionnaire was utilized to gather their demographic information, and direct interviews were conducted with the subjects. To examine random blood sugar (RBS), white blood cell (WBC) count, creatinine level, and blood urea nitrogen (BUN), blood samples were obtained from the subjects. The mentioned parameters were analyzed using SPSS 22.0. Results: According to the results, the groups were homogenous in age, body mass index (BMI), and male-to-female ratio. However, there were significant differences between the two groups in RBS (P=0.011), WBC count (P=0.031), creatinine level (P=0.001), and BUN (P=0.001). Conclusion: Failure of allograft survival of renal transplantation was found to be a leading cause of death, which has been reportedly been treated by the consumption of immunosuppressive drugs such as CsA. However, this drug can increase the patient’s chances of developing PTDM. PTDM development can be reduced by applying a dosage of 10 mg/kg/d during the first week and 8-9 mg/kg/day during weeks 2-5 following transplantation.

scholarly journals Pattern of Cancer in Irrua Specialist Teaching Hospital

2021 ◽  
pp. 14-21
Author(s):  
Clifford Ikhuoria Owobu ◽  
Akhator Terence Azeke ◽  
Victor Valentine Ideiyenmin ◽  
Orume Enegbuya ◽  
Adaugo Chizoma Owobu ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Cancer Registration ◽  
Female Ratio ◽  
Cancer Breast ◽  
Non Melanoma Skin Cancer ◽  
Organ Tissue ◽  
Cancer Types ◽  
The Common ◽  
Male To Female ◽  
Gender Specific

Aims: To reveal the pattern and trend of cancer in a predominantly rural population in Nigeria and compare the findings with those of earlier researches across the world. Study Design: A descriptive retrospective analysis of all cancer cases seen among surgical specimens in Irrua Specialist Teaching Hospital. The cancer cases are classified according to the organ/tissue involved and the data obtained were analysed using SPSS (version 25). Place and Duration of Study: The Department of Anatomic Pathology, Irrua Specialist Teaching Hospital, Nigeria; between January 2011 and December 2020. Results: A total of 9,058 histologic samples were reviewed out of which 1,474 (16.27%) were cancer cases. The yearly number of cancer cases increased from 85 in 2011, to 258 over the next 10-year study period. At variance with WHO 2020 GLOBOCAN worldwide estimates, the common cancer types seen in this study (both sexes combined) were prostate cancer, breast cancer, cervical cancer, colorectal cancer and non-melanoma skin cancer, in decreasing frequencies. The peak age of occurrence was the 7th decade while the mean age was 54.21 years, and the gender-specific mean ages for males and females were 59.92 years and 49.44 years respectively. The male to female ratio was 1:1.2 and males are more likely to be diagnosed of cancer approximately 10 years later than their female counterparts. Conclusion: Many of the findings in this study are similar to those of previous researches across the country. It is our hope that the findings in this study would contribute to national data and be found useful in efforts to build a more inclusive and robust national system of cancer registration.

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