scholarly journals Hormonal Perturbations in Occupationally Exposed Nickel Workers

2016 ◽  
Vol 4 (2) ◽  
pp. 307-311 ◽  
Author(s):  
Safia Beshir ◽  
Khadiga Salah Ibrahim ◽  
Weam Shaheen ◽  
Eman M. Shahy
Keyword(s):  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Sexual Disorders ◽  
Cross Sectional ◽  
Serum Luteinizing Hormone ◽  
Exposed Workers ◽  
Occupationally Exposed ◽  
Nickel Exposure ◽  
Male Sexual Function ◽  
Stimulating Hormone

BACKGROUND: Nickel exposure is recognized as an endocrine disruptor because of its adverse effects on reproduction.AIM: This study was designed to investigate the possible testiculo-hormonal perturbations on workers occupationally exposed to nickel and to assess its effects on human male sexual function. METHODS: Cross-sectional comparative study, comprising 105 electroplating male non-smoker, non-alcoholic workers exposed to soluble nickel and 60 controls was done. Serum luteinizing hormone, follicle stimulating hormone, testosterone levels and urinary nickel concentrations were determined for the studied groups. RESULTS: Serum luteinizing hormone, follicle stimulating hormone, urinary nickel and the simultaneous incidence of more than one sexual disorder were significantly higher in the exposed workers compared to controls. The occurrence of various types of sexual disorders (decreased libido, impotence and premature ejaculation) in the exposed workers was 9.5, 5.1 and 4.4 folds respectively than the controls.CONCLUSIONS: Exposure to nickel produces possible testiculo-hormonal perturbations in those exposed workers.

scholarly journals Comparison of inhibitory effect of ibuprofen with Piper guineense Schumach and Thonn. on some reproductive hormones in female rats

2017 ◽  
Vol 6 (4) ◽  
pp. 205-209
Author(s):  
Emmanuel Onuka Agbai ◽  
◽  
Chisomaga Chiwuikem Eke ◽  
Collins Okechukwu Nwanegwo ◽  
Ugochukwu Bond Anyaehie ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Inhibitory Effect ◽  
Female Rats ◽  
Assay Method ◽  
Piper Guineense ◽  
Serum Luteinizing Hormone ◽  
Group B ◽  
Group D ◽  
Stimulating Hormone

The aim of the present study was to compare the inhibitory effect of ibuprofen with oral administration of Piper guineense leaf extract on follicle-stimulating hormone, luteinizing hormone, progesterone and estrogen in female rats irrespective of the estrous cycle. The animals were randomly assigned to four groups (n = 7): group A (control), Group B, 180 mg-kg of ibuprofen, Group C, 200 mg-kg of Piper guineense extract, Group D, 180 mg-kg of ibuprofen and 200 mg-kg of Piper guineense extract. At the end of two weeks administration, rats were sacrificed under urethane anesthesia and hormones measured using enzyme-linked immunosorbent assay method. Results showed significant reduction in serum follicle-stimulating hormone and luteinizing hormone following ibuprofen administration in Group B rats at P < 0.05. Piper guineense extract treated Group C rats caused significant reduction in serum luteinizing hormone and progesterone at P < 0.05. In contrast, serum follicle stimulating hormone significantly increased in Group D rats at P < 0.05 whereas serum luteinizing hormone and progesterone were markedly reduced at P < 0.05. Serum estrogen level remained unchanged among groups. In conclusion, results obtained suggested that extract inhibited luteinization of follicles thus could impair ovulation, therefore the extract can be used as oral contraceptive in family planning.

Sign in / Sign up

Export Citation Format

Share Document