scholarly journals Dobrava virus: a mortal agent of hemorrhagic fever with renal syndrome

2013 ◽  
Vol 7 (10) ◽  
pp. 767-768
Author(s):  
Selçuk Kaya
Keyword(s):  
Full Text ◽  
Hemorrhagic Fever ◽  
Dobrava Virus

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scholarly journals Dobrava Virus Carried by the Yellow-Necked Field Mouse Apodemus flavicollis, Causing Hemorrhagic Fever with Renal Syndrome in Romania

2014 ◽  
Vol 14 (5) ◽  
pp. 358-364 ◽  
Author(s):  
Raluca Ioana Panculescu-Gatej ◽  
Anca Sirbu ◽  
Sorin Dinu ◽  
Maria Waldstrom ◽  
Paul Heyman ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Field Mouse ◽  
Apodemus Flavicollis ◽  
Dobrava Virus

Belgrade Virus, a Cause of Hemorrhagic Fever with Renal Syndrome in the Balkans, is Closely Related to Dobrava Virus of Field Mice

1993 ◽  
Vol 168 (3) ◽  
pp. 750-753 ◽  
Author(s):  
A. M. Taller ◽  
S.-Y. Xiao ◽  
M. S. Godec ◽  
A. Gligic ◽  
T. Avsic-Zupanc ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
The Balkans ◽  
Dobrava Virus ◽  
Field Mice

scholarly journals Dobrava Virus RNA Load in Patients Who Have Hemorrhagic Fever with Renal Syndrome

2008 ◽  
Vol 197 (5) ◽  
pp. 681-685 ◽  
Author(s):  
Ana Saksida ◽  
Darja Duh ◽  
Misa Korva ◽  
Tatjana Avsic‐Zupanc
Keyword(s):  
Hemorrhagic Fever ◽  
Dobrava Virus ◽  
Virus Rna

scholarly journals HLA-Associated Hemorrhagic Fever with Renal Syndrome Disease Progression in Slovenian Patients

2011 ◽  
Vol 18 (9) ◽  
pp. 1435-1440 ◽  
Author(s):  
Miša Korva ◽  
Ana Saksida ◽  
Sabina Kunilo ◽  
Blanka Vidan Jeras ◽  
Tatjana Avšič-Županc
Keyword(s):  
Strong Association ◽  
Hemorrhagic Fever ◽  
Class Ii ◽  
Protective Role ◽  
Severe Form ◽  
Slovenian Population ◽  
Dobrava Virus ◽  
Histocompatibility Complex ◽  
Severity Of The Disease ◽  
Hla Molecules

ABSTRACTMajor histocompatibility complex (MHC) class I and class II genes regulate the balance between appropriate aggressive responses and invading pathogens while minimizing the destruction of host tissue. Several studies have shown that in hemorrhagic fever with renal syndrome (HFRS) patients, the disease outcome is determined by a complex interaction between the virus and immunopathologic and human genetic factors. In Slovenia, the severity of the disease caused by Puumala virus (PUUV) is significantly lower than that of HFRS due to Dobrava virus (DOBV). We have determined 23 different HLA-B and 12 different HLA-DRB1 types in Slovenian HFRS patients. Comparison of HLA frequencies between healthy individuals and HFRS patients showed no strong association with the susceptibility for hantaviral infection. Significant associations were recognized when the patient group was separated according to the virus responsible for the infection. DOBV-infected patients have a significantly higher frequency of HLA-B*35 than PUUV-infected patients. For HLA class II genes, the biggest difference between the PUUV- and DOBV-infected groups of patients was in HLA-DRB1*13, where this phenotype was more frequent in PUUV-infected patients, especially in the severe form of the disease. HLA-B*07 could play a protective role in PUUV-caused HFRS in the Slovenian population. Our study shows diverse associations of HLA molecules with DOBV- and PUUV-induced HFRS, and therefore, we presume that different hantaviruses are presented differently through the same HLA molecules and that this might lead to either a more severe or a milder form of the disease. In line with this idea, we have noticed that HLA-B*35 might be a genetic risk factor for DOBV infection in the Slovenian population.

scholarly journals Molecular Diagnostics of Hemorrhagic Fever with Renal Syndrome during a Dobrava Virus Infection Outbreak in the European Part of Russia

2009 ◽  
Vol 47 (12) ◽  
pp. 4029-4036 ◽  
Author(s):  
T. K. Dzagurova ◽  
B. Klempa ◽  
E. A. Tkachenko ◽  
G. P. Slyusareva ◽  
V. G. Morozov ◽  
...  
Keyword(s):  
Virus Infection ◽  
Molecular Diagnostics ◽  
Hemorrhagic Fever ◽  
European Part ◽  
Dobrava Virus ◽  
European Part Of Russia

scholarly journals Development of Novel Immunoglobulin G (IgG), IgA, and IgM Enzyme Immunoassays Based on Recombinant Puumala and Dobrava Hantavirus Nucleocapsid Proteins

2006 ◽  
Vol 13 (12) ◽  
pp. 1349-1357 ◽  
Author(s):  
Helga Meisel ◽  
Anne Wolbert ◽  
Ausra Razanskiene ◽  
Andreas Marg ◽  
Andris Kazaks ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Hemorrhagic Fever ◽  
Virus Infections ◽  
Serum Samples ◽  
Nucleocapsid Proteins ◽  
Dobrava Virus ◽  
Acute Infections ◽  
Antibody Capture ◽  
Human Infections ◽  
Heterologous Antigens

ABSTRACT Human infections with Asian and European hantaviruses can result in hemorrhagic fever with renal syndromes of differing severities characterized by renal dysfunction and sometimes by pulmonary symptoms. For the serological detection of human infections by hantaviruses relevant for Europe, we developed monoclonal antibody capture immunoglobulin G (IgG) and IgA enzyme-linked immunosorbent assays (ELISAs) based on yeast-expressed nucleocapsid proteins of Puumala and Dobrava hantaviruses. Moreover, for diagnosis of acute infections, μ-capture IgM ELISAs were established with nucleocapsid proteins expressed in Drosophila melanogaster Schneider S2 cells. The cutoff values of the ELISAs were determined by investigation of up to 500 human anti-hantavirus-negative serum samples. The specificities of the Puumala and Dobrava virus-specific IgM, IgA, and IgG ELISAs were found to be 100%. The sensitivities of these ELISAs were determined to be 100% with panels of characterized anti-Puumala or anti-Dobrava virus-positive human serum samples. In most cases, Puumala and Dobrava virus infections could be differentiated by ELISA reactivity alone, i.e., endpoint titration with homologous and heterologous antigens.

scholarly journals Clinical and virological characteristics of hantavirus infections in a 2014 Croatian outbreak

2017 ◽  
Vol 11 (01) ◽  
pp. 73-80 ◽  
Author(s):  
Tatjana Vilibic-Cavlek ◽  
Alena Furic ◽  
Ljubo Barbic ◽  
Irena Tabain ◽  
Vladimir Stevanovic ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Acute Infection ◽  
Laboratory Data ◽  
Hemorrhagic Fever ◽  
Immunofluorescence Assay ◽  
Lumbar Pain ◽  
Igg Antibodies ◽  
Clinical Form ◽  
Dobrava Virus ◽  
Natural Foci

Introduction: Croatia is endemic for hemorrhagic fever with renal syndrome (HFRS), with both Puumala (PUUV) and Dobrava virus (DOBV) documented. Several large outbreaks were recorded in 1995, 2002, and 2012. We analyzed demographic, clinical, laboratory, and virological characteristics of HFRS cases detected in three geographically close natural foci (Ogulin, Slunj, and the Plitvice Lakes surroundings) during the 2014 outbreak. Methodology: From January to December 2014, 122 patients with suspected HFRS were tested for hantavirus IgM/IgG antibodies using an indirect immunofluorescence assay (IFA). Cross-reactive samples were further tested using a western blot (WB). For hospitalized patients from Ogulin area, clinical and laboratory data were analyzed. Results: Acute infection was documented in 57 (46.7%) patients, of whom 75.4% were hospitalized. Ten (8.2%) patients were found to be IgG seropositive. Patients were 15–69 years of age and predominantly male (74.5%). The outbreak started in winter months, with most cases recorded from May to July (80.7%). The most frequently reported symptoms were fever (96.3%), chills/shivering (62.9%), and lumbar pain (48.1%). Mild clinical form was found in 66.7% patients, moderate in 18.5%, and severe in 14.8% patients (all but one infected with PUUV). One patient died. Using IFA, 48.8% patients showed monotypic antibody response, while in 51.2%, cross-reactive antibodies were found. PUUV was confirmed in 94.7% and DOBV in 5.3% HFRS cases by WB. Conclusions: Central mountainous Croatian regions are still highly endemic areas for HFRS. A higher percentage of severe PUUV infections could be at least partly associated with a patient’s immune status.

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