scholarly journals Acute and chronic Chlamydia pneumoniae infection and inflammatory markers in coronary artery disease patients

2011 ◽  
Vol 5 (08) ◽  
pp. 580-586 ◽  
Author(s):  
Mehvash Haider ◽  
Meher Rizvi ◽  
Abida Malik ◽  
Mohammad Azam ◽  
Mohammad Urooj Rabbani
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Unstable Angina ◽  
Chlamydia Pneumoniae ◽  
Mean Value ◽  
Iga Antibodies ◽  
Ifn Γ ◽  
Traditional Risk Factors ◽  
Artery Disease

Introduction: We evaluated the role of inflammation and acute or persistent Chlamydia pneumoniae infection in coronary artery disease (CAD).      Methodology: The study involved 63 cardiovascular disease patients diagnosed with angina and myocardial infarction (MI) and 40 healthy controls. ELISA was performed for detection of C. pneumoniae IgA antibodies and for quantitative analysis of IFN-γ. PCR was performed for detection of the C. pneumoniae 16 SrRNA gene in blood. Results: C. pneumoniae IgA antibodies were detected in 66.66% cases and 41.37% controls. Of IgA seropositive cases 71.43% were MI patients, 61.90% were stable angina patients, and 64.29% unstable angina patients. Of 40 patients whose PCR was done 32.5% were positive of which 76.92% were IgA seropositive. Traditional risk factors were not significantly associated with CAD. The mean value of IFN-γ in cases was 32.12pg/ml and 11.32pg/ml in controls. Elevated IFN-γ was observed in 76.92% of C. pneumoniae IgA seropositives with a mean value of IFN-γ in angina patients of 3.39pg/ml, in unstable angina of 12.91 pg/ml and in MI patients of 23.89 pg/ml. IFN-γ levels in cases who were positive for C. pneumoniae infection by serology and PCR was 55.21 pg/ml. Conclusion: C. pneumoniae infection was significantly associated with CAD risk. The role of acute or persistent infection in progression of CAD to adverse clinical outcome was evident by a high percentage of seropositives among PCR positives. Although IFN-γ alone had a role to play in development of CAD, its values were further enhanced due to recurrent C. pneumoniae infection.

scholarly journals Association of Plasma Circulatory Markers,Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Hem Chandra Jha ◽  
Pragya Srivastava ◽  
Rakesh Sarkar ◽  
Jagdish Prasad ◽  
Aruna Singh Mittal
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Inflammatory Markers ◽  
Chlamydia Pneumoniae ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Artery Disease ◽  
Adhesive Molecules ◽  
Plasma Markers

Plasma inflammatory markers have been shown to be predictors for cardiovascular risk, however, there is no study where the levels of plasma circulatory markers have been evaluated in coronary artery disease patients (CAD pts) positive forC. pneumoniaeIgA and high sensitive C-reactive protein (hsCRP) which may help in better understanding of disease pathogenesis. A total of 192 patients and 192 controls attending the Cardiology Outpatient Department of Safdarjung Hospital were enrolled. The levels of plasma circulatory inflammatory markers were evaluated by ELISA. The levels of circulatory plasma markers (IL-4, IL-8, IL-13, ICAM-1, and VCAM-1) were significantly higher, whereas, levels of IL-10 and IFN-γwere significantly lower in CAD pts compared to healthy controls. The levels of IL-4, IL-8, and ICAM-1 (P=.007, .015, and .048) were significantly higher, however, IL-10 and IFN-γwere significantly lower (P<.001,<.001) inC. pneumoniaeIgA positive CAD pts. The levels of IL-4, IL-8, IL-13, ICAM-1, and VCAM-1 were higher but not significant and levels of IL-10 and IFN-γwere significantly (P<.001,<.001) lower in hsCRP positive CAD pts. Our study suggested that circulatory cytokines, namely, IL-4, IL-8, and adhesive molecules like ICAM-1 were enhanced after infection withC. pneumoniaewhereas in contrast to this IL-10 and IFN-λwere lowered. Suggesting the important role of these cytokines in progression of CAD.

scholarly journals The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease

2016 ◽  
Vol 24 (1) ◽  
pp. 157-163 ◽  
Author(s):  
Ahmed Amara ◽  
Meriem Mrad ◽  
Aicha Sayeh ◽  
Dhaker Lahideb ◽  
Samy Layouni ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Polymerase Chain Reaction Amplification ◽  
Control Group ◽  
Mortality And Morbidity ◽  
Tunisian Patients ◽  
Traditional Risk Factors ◽  
Artery Disease

Background: Coronary artery disease (CAD), also known as atherosclerotic heart disease, is a leading cause of mortality and morbidity throughout the world. The role of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene in the etiology of CAD remains to be more completely clarified. The aim of this study was to determine the role of the ACE I/D polymorphism in patients with CAD and to study the association together with traditional risk factors in assessing the risk of CAD. Methods: Our study population included 145 Tunisian patients with symptomatic CAD and a control group of 300 people matched for age and sex. All participants in the study were genotyped for the ACE I/D polymorphisms obtained by polymerase chain reaction amplification on genomic DNA. Results: Our analysis showed that the ACE D allele frequency ( P < 10−3; odds ratio [OR] = 5.2; 95% confidence interval [CI] = 3.6-7.6) and DD genotype ( P < 10−3; OR = 6.8; 95% CI = 4.4-10) are significantly more prevalent among patients with CAD than in controls and may be predisposing to CAD. We further found that the risk of CAD is greatly potentiated by several concomitant risk factors (smoking, diabetes, hypertension, dyslipidemia, and a family history of CAD). Conclusion: The ACE D allele may be predictive in individuals who may be at risk of developing CAD. Further investigations of these polymorphisms and their possible synergisms with traditional risk factors for CAD could help to ascertain better predictability for CAD susceptibility.

scholarly journals Pathohistological changes in diffuse coronary atherosclerosis and chronic infection caused by Chlamydia pneumonia.

2004 ◽  
Vol 4 (1) ◽  
pp. 19-22
Author(s):  
Mateja Legan ◽  
Olga Vraspir-Porenta ◽  
Darja Kese ◽  
Ruda Zorc-Plesković ◽  
Marjeta Zorc
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Infection ◽  
Vessel Wall ◽  
Chlamydia Pneumoniae ◽  
Diffuse Coronary Artery Disease ◽  
Artery Disease ◽  
Immunofluorescent Test ◽  
Mib 1

BACKGROUND AND PURPOSE: To investigate the histopathologic characteristics of atherosclerotic lessions in diffuse coronary artery disease and to evaluate the possible inflammatory role of chronic infection with Chlamydia pneumoniae (CP).MATERIALS AND METHODS: For 10 patients (males, mean age 61 years) who were surgically treated for grave diffuse coronary artery disease, histomorphological analyses of endarterectomized segments of the coronary arteries were performed. Serological analyses for the detection of CP antibodies in peripheral blood were done, preoperatively.RESULTS AND CONCLUSIONS: Diffuse and concentric atherosclerotic changes from VI to VIII stage according to the Stary classification were found. Immunohistochemical methods revealed infiltrates of T-lymphocytes (80% of cases), B-lymphocytes (40% of cases) and macrophages (80%). Using the nuclear marker for proliferation activity MIB-1, single MIB-1 positive cells were found in 40% of cases. Features of arteriologenesis and vasculitis of newly formed arterioles (as well as thickening of the wall of newly formed arterioles) were found in the vessel wall of 8 patients, 7 of them had chronic infection with CP (preoperative micro-immunofluorescent test results: 1:32<IgG ≥1:512 and IgA≥32), one had passed CP infection (1:32 ≤IgG<1:512, IgA negative). These features were absent in 2 patients, both recovered from CP infection and had not the chronic CP infection at the time of surgery. DNA of Chlamydia pneumoniae was detected using the polymerase chain reaction (PCR) method in the vessel wall of 3 patients who were chosen randomly for this method. This study suggests an inflammatory and proatherogenic role of CP in a high grade atherosclerotic coronary artery wall in diffuse coronary artery disease.

scholarly journals Association between plasma betaine levels and dysglycemia in patients with coronary artery disease

2020 ◽  
Vol 40 (8) ◽  
Author(s):  
Fei Guo ◽  
Xueting Qiu ◽  
Yuanting Zhu ◽  
Zhirong Tan ◽  
Zhenyu Li ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Metabolic Disorders ◽  
Glycated Hemoglobin ◽  
Fasting Glucose ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Traditional Risk Factors ◽  
Artery Disease

Abstract Background: Dietary betaine intake was reported to associate with favorable profile of metabolic disorders. However, the role of circulating betaine in coronary artery disease (CAD) patients with dysglycemia is still unknown. The present study aimed to investigate the potential associations between plasma betaine levels and dysglycemia in CAD patients. Methods: Total 307 subjects were enrolled in the present study with 165 CAD patients (57 with dysglycemia and 108 with normal glycemia) and 142 age- and sex-matched controls (CON). Fasting plasma betaine was detected using liquid chromatography tandem mass spectrometry. Results: Plasma betaine was lower in normal glycemia CAD patients (28.29 (22.38–35.73) μM) compared with healthy controls (29.75 (25.32–39.15) μM), and was further decreased in CAD patients with dysglycemia (24.14 (20.84–30.76) μM, P&lt;0.01). Betaine levels were inversely correlated with fasting glucose, glycated hemoglobin% (HbA1c), diastolic blood pressure (DBP), triglyceride (TG) and alanine aminotransferase (ALT) levels (all, P≤0.05). Subjects in the highest betaine tertile group had lowest frequency of CAD and dysglycemia (all, P&lt;0.01). Increased betaine levels were independently associated with low risk of dysglycemia in CAD after adjustment for multiple traditional risk factors (OR = 0.04, 95% CI: 0–0.37, P=0.01). Furthermore, betaine had good performance at distinguishing CAD with dysglycemia from normal glycemia CAD (AUC = 0.62, P&lt;0.01). Conclusion: Plasma betaine levels are independently and inversely associated with dysglycemia in CAD after adjustment for multiple factors, and may be useful for risk stratification of dysglycemia in CAD.

scholarly journals The Role of N-terminal Prohormone of Brain Natriuretic Peptide in the Severity of Coronary Artery Disease (Gensini Score) in Patients with Unstable Angina

2019 ◽  
Vol 06Sp, 07 & 07h (1 & 1) ◽  
Author(s):  
Seyed Mohammad Hassan Adel ◽  
◽  
Seyed Mohammadreza Afshani ◽  
Nehzat Akiash ◽  
Seyed Amir Ali Adel ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Brain Natriuretic Peptide ◽  
Unstable Angina ◽  
Natriuretic Peptide ◽  
Gensini Score ◽  
Artery Disease
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