scholarly journals Mid-arm and epitrochlear lymphadenopathy: a clinico-radiological surprise

2011 ◽  
Vol 5 (11) ◽  
pp. 820-824 ◽  
Author(s):  
Pankaj Kumar Garg ◽  
Bhupendra Kumar Jain ◽  
Vinita Rathi ◽  
Navjeevan Singh ◽  
Debajyoti Mohanty
Keyword(s):  
Lymph Nodes ◽  
Therapeutic Response ◽  
Antigen Test ◽  
Subcutaneous Nodules ◽  
Filarial Antigen ◽  
Circulating Filarial Antigen

An 18-year-old man presented with multiple subcutaneous nodules over the anteromedial aspect of his right lower arm. Based on findings of sonography, histopathology, circulating filarial antigen test, and therapeutic response to diethylcarbazine, a diagnosis of filarial lymphadenopathy affecting mid-arm nodes and epitrochlear lymph nodes was made.

Circulating filarial antigen detection in brugian filariasis

Parasitology ◽  
2015 ◽  
Vol 143 (3) ◽  
pp. 350-357
Author(s):  
PRAVEEN KUMAR TRIPATHI ◽  
RAMESH CHANDER MAHAJAN ◽  
NANCY MALLA ◽  
ABHISHEK MEWARA ◽  
SHAILJA MISRA BHATTACHARYA ◽  
...  
Keyword(s):  
Adult Worm ◽  
Specific Antigen ◽  
Antigen Detection ◽  
Serum Samples ◽  
Helminthic Infections ◽  
Filarial Antigen ◽  
Endemic Normal ◽  
Grade Iii ◽  
Antigen Reactivity ◽  
Circulating Filarial Antigen

SUMMARYHuman lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of tools for diagnosis and treatment. In this study on stage-specific antigen detection in brugian filariasis, L3, adult worm (AW) and microfilarial antigenaemia were detected in around 90–95% of microfilariae carriers (MF group), 50–70% of adenolymphangitis (ADL) patients, 10–25% of chronic pathology (CP) patients and 10–15% of endemic normal (EN) controls. The sensitivity of the circulating filarial antigen (CFA) detection in serum samples from MF group was up to 95%. In sera from ADL patients, unexpectedly, less antigen reactivity was observed. In CP group all the CFA positive individuals were from CP grade I and II only and none from grade III or IV, suggesting that with chronicity the AWs lose fecundity and start to disintegrate and die. Amongst EN subject, 10–15% had CFA indicating that few of them harbour filarial AWs, thus they might not be truly immune as has been conventionally believed. The specificity for antigen detection was 100% when tested with sera from various other protozoan and non-filarial helminthic infections.

scholarly journals Rare incidence of non-secretory myeloma with talaromycosis: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haiting Qin ◽  
Ye Qiu ◽  
Yanmei Huang ◽  
Mianluan Pan ◽  
Dong Lan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Marrow ◽  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Clinical Symptoms ◽  
Subcutaneous Tissue ◽  
Community Acquired Pneumonia ◽  
Pathological Examination ◽  
Subcutaneous Nodules ◽  
Lung Lymph

Abstract Background Talaromyces marneffei (TM) primarily infects patients with co-morbidities that cause immunodeficiency, but non-secretory myeloma (NSMM) is rare. TSM and NSMM are associated with fever, osteolysis, and swollen lymph nodes, thereby making it difficult for clinicians to make differential diagnosis. In this case, we describe TM infection coexisting with NSMM. Case presentation We retrospectively reviewed the case of a male (without human immunodeficiency virus infection) with fever, thoracalgia, swollen lymph nodes, and subcutaneous nodules who presented to the First Affiliated Hospital of Guangxi Medical University in February 2014. Chest computed tomography revealed patchy infiltration and positron emission tomography/computed tomography showed increased metabolic activity in the lower-right lung, lymph nodes, left ninth rib, and right ilium. Pathological examination of the lung, lymph nodes, subcutaneous nodules, and bone marrow showed no malignancy, he was diagnosed with community-acquired pneumonia. His clinical symptoms did not improve after anti-bacterial, anti-Mycobacterium tuberculosis, and anti-non-M. tuberculosis treatment. Later, etiological culture and pathological examination of the subcutaneous nodule proved TM infection, and the patient was re-diagnosed with disseminated TSM, which involved the lungs, lymph nodes, skin, bone, and subcutaneous tissue. After antifungal treatment, the patient showed significant improvement, except for the pain in his bones. Imaging showed aggravated osteolysis, and bone marrow biopsy and immunohistochemistry indicated NSMM. Thus, we conclusively diagnosed the case as NSMM with TSM (involving the lungs, lymph nodes, skin, and subcutaneous tissue). His condition improved after chemotherapy, and he was symptom-free for 7 years. Conclusion TM infection is rare in individual with NSMM. Since they have clinical manifestation in common, easily causing misdiagnosis and missed diagnosis, multiple pathological examinations and tissue cultures are essential to provide a differential diagnosis.

Analysis, characterization and diagnostic use of circulating filarial antigen in bancroftian filariasis

1990 ◽  
Vol 15 (1) ◽  
pp. 37-46 ◽  
Author(s):  
K. A. Parkhe ◽  
M. V. R. Reddy ◽  
K. Cheirmaraj ◽  
P. Ramaprasad ◽  
B. C. Harinath
Keyword(s):  
Bancroftian Filariasis ◽  
Diagnostic Use ◽  
Filarial Antigen ◽  
Circulating Filarial Antigen

scholarly journals Semi-Quantitative Scoring of an Immunochromatographic Test for Circulating Filarial Antigen

2013 ◽  
Vol 89 (5) ◽  
pp. 916-918 ◽  
Author(s):  
Cédric B. Chesnais ◽  
Jean Bopda ◽  
Andrew C. Majewski ◽  
Sébastien D. S. Pion ◽  
Michel Boussinesq ◽  
...  
Keyword(s):  
Immunochromatographic Test ◽  
Filarial Antigen ◽  
Quantitative Scoring ◽  
Circulating Filarial Antigen

scholarly journals Determination of the prevalence of lymphatic filariasis among migrant workers in Kuwait by detecting circulating filarial antigen

2006 ◽  
Vol 55 (4) ◽  
pp. 401-405 ◽  
Author(s):  
Jamshaid Iqbal ◽  
Ali Sher
Keyword(s):  
Sensitivity And Specificity ◽  
Migrant Workers ◽  
Indian Subcontinent ◽  
Wuchereria Bancrofti ◽  
Parasitic Infections ◽  
Filarial Infection ◽  
Filarial Antigen ◽  
Sensitivity Specificity ◽  
Circulating Filarial Antigen

The main objective of this study was to determine the prevalence of filarial infection among migrant workers in Kuwait. The study was conducted from April 2000 to November 2003. A total of 1050 migrant workers (>90 % from the Indian subcontinent) from filarial endemic countries and 260 individuals residing in Kuwait as controls (50 healthy Kuwaiti blood donors, 50 microfilaria-negative individuals from endemic areas and 160 patients with other parasitic infections) were screened for filarial infection. All specimens were tested for microfilaraemia by microscopy of nucleopore-filtered blood (NFB) and detection of circulating filarial antigen (CFA) by an immunochromatographic test (ICT) and the TropBio assay. The overall prevalence of filarial antigenaemia was 18·3 % (192 individuals) using the ICT and 20·3 % (213 individuals) using the TropBio assay. Thirty-two cases (3 %) of Wuchereria bancrofti were detected by microscopy and the mean microfilaria count in these cases was 816 microfilariae ml−1. CFA was detected only in two of the 260 control subjects. Statistical analysis to calculate the sensitivity, specificity and prevalence of infection was carried out using maximum-likelihood statistical methods. The overall sensitivity and specificity of the ICT and TropBio assay to detect CFA were comparable. Compared with NFB microscopy, the sensitivity of the ICT was 93·8 % and specificity ranged from 84 to 100 %. The sensitivity and specificity of the TropBio assay were 90·1 and 100 %, respectively. However, the ICT failed to detect CFA in two cases with a microfilarial load of <20 microfilariae ml−1. In conclusion, the prevalence of filarial infection among the migrant workers in Kuwait was 18·3 % as determined by the ICT.

scholarly journals Incidence of filariasis in clinically diagnosed primary vaginal hydrocele

2020 ◽  
Vol 7 (3) ◽  
pp. 640
Author(s):  
Mahendra Bendre ◽  
Shrreya Akhil ◽  
Srujan Kondreddy
Keyword(s):  
Histopathological Examination ◽  
Peripheral Blood Smear ◽  
Cross Sectional Study ◽  
Research Centre ◽  
Bancroftian Filariasis ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Filarial Antigen ◽  
Circulating Filarial Antigen

Background: Lymphatic filariasis is caused by a mosquito-borne parasite affecting roughly 100 million people round the world. There is consensus that hydrocele is the most frequent clinical manifestation of bancroftian filariasis. In endemic areas, about 40% of men are suffering from testicular hydrocele. With this background, the present study was aimed to find the incidence of filariasis in clinically diagnosed primary vaginal hydrocele.Methods: A hospital based prospective, cross-sectional study was conducted with 60 patients diagnosed clinically as primary vaginal hydrocele coming to the department of surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, to assess the incidence of filariasis.Results: Anti-filarial antibody and circulating filarial antigen in serum were detected in 5 (8.3%). Out of 60 patients and anti-filarial antibody was detected in hydrocele fluid of 2 (3.3%) patients. 2 patients out of these 5 showed microfilaria in peripheral blood smear and eosinophilic infiltrates in histopathological examination of sac.Conclusions: In 5 out of 60 cases both anti-filarial antibody and circulating filarial antigen in serum are positive thus proving that incidence of filarial hydrocele is 8% in clinically diagnosed primary vaginal hydrocele which is supposed to be idiopathic. Even though these cases have presented as clinically primary vaginal hydrocele, they are found to be filarial hydrocele after analysis of serum and hydrocele fluid. So, it is advised that all cases of clinically diagnosed primary vaginal hydroceles should be investigated for filariasis and if not, may lead to recurrence in these cases.

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