scholarly journals The Bayesian reconstruction and the evolutionary history of Salivirus type 1 and type 2: the worldwide spreading

2021 ◽  
Vol 15 (02) ◽  
pp. 280-288
Author(s):  
Silvia Angeletti ◽  
Domenico Benvenuto ◽  
Marta Fogolari ◽  
Cecilia De Flora ◽  
Giancarlo Ceccarelli ◽  
...  
Keyword(s):  
Phylogenetic Tree ◽  
Evolutionary History ◽  
Homology Modelling ◽  
Model Fitting ◽  
Evolutionary Model ◽  
History Of ◽  
Probable Origin ◽  
Pressure Analysis

Introduction: Salivirus (SalV) represents an emerging problem in public health especially during the recent years. In this study, the Bayesian evolutionary history and the spread of the virus through the different countries have been reported. Methodology: a database of 81 sequences of SalV structural VP1 fragment were downloaded from GenBank, aligned and manually edited by Bioedit Software. ModelTest v. 3.7 software was used to estimate the simplest evolutionary model fitting the sequence dataset. A Maximum-Likelihood tree has been generated using MEGA-X to test the “clockliness” signal using TempEst 1.5.1. The Bayesian phylogenetic tree was built by BEAST. Homology modelling was performed by SWISS-Model and protein variability evaluated by ConSurf server. Results: the phylogenetic tree showed a clade of SalV A2 and three main clades of SalV A1, revealing several infections in humans in South Korea, India, Tunisia, China, Nigeria, Ethiopia and USA. The Bayesian maximum clade credibility tree and the time of the most common recent ancestor dated back the root of the tree to the year 1788 with the probable origin in USA. Selective pressure analysis revealed two positive selection sites, His at 100th and Leu at 116th positions that at the homology modelling resulted important to guarantee protein stability and variability. This could contribute to the development of new mutations modifying the clinical features of this evolving virus. Conclusions: Bayesian phylogenetic and phylodynamic represented a useful tool to follow the transmission dynamic of SalV and to prevent new epidemics worldwide.

scholarly journals EXPRESS: Pulmonary Hypertension Associated With Neurofibromatosis Type 2

2021 ◽  
pp. 204589402110295
Author(s):  
Hirohisa Taniguchi ◽  
Tomoya Takashima ◽  
Ly Tu ◽  
Raphaël Thuillet ◽  
Asuka Furukawa ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Neurofibromatosis Type ◽  
Pulmonary Vascular Remodeling ◽  
Life Threatening ◽  
History Of ◽  
Pulmonary Arterial ◽  
First Time

Although precapillary pulmonary hypertension (PH) is a rare but severe complication of patients with neurofibromatosis type 1 (NF1), its association with NF2 remains unknown. Herein, we report a case of a 44-year-old woman who was initially diagnosed with idiopathic pulmonary arterial hypertension (IPAH) and treated with PAH-specific combination therapy. However, a careful assessment for a relevant family history of the disease and genetic testing reveal that this patient had a mutation in the NF2 gene. Using immunofluorescence and Western blotting, we demonstrated a decrease in endothelial NF2 protein in lungs from IPAH patients compared to control lungs, suggesting a potential role of NF2 in PAH development. To our knowledge, this is the first time that precapillary PH has been described in a patient with NF2. The altered endothelial NF2 expression pattern in PAH lungs should stimulate work to better understand how NF2 is contributing to the pulmonary vascular remodeling associated to these severe life-threatening conditions.

Maternal history of type 2 diabetes is associated with diabetic nephropathy in type 1 diabetic patients

2007 ◽  
Vol 33 (1) ◽  
pp. 37-43 ◽  
Author(s):  
S. Hadjadj ◽  
F. Duengler ◽  
F. Torremocha ◽  
G. Faure-Gerard ◽  
F. Bridoux ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Diabetic Patients ◽  
Maternal History ◽  
History Of ◽  
Type 1 Diabetic Patients

scholarly journals Cannabinoids in health and disease: pharmacological potential in metabolic syndrome and neuroinflammation

2018 ◽  
Vol 36 (2) ◽  
Author(s):  
Andrea Mastinu ◽  
Marika Premoli ◽  
Giulia Ferrari-Toninelli ◽  
Simone Tambaro ◽  
Giuseppina Maccarinelli ◽  
...  
Keyword(s):  
Cannabis Sativa ◽  
Cannabinoid Receptor ◽  
Receptor Type ◽  
History Of ◽  
Health And Disease ◽  
Pharmacological Potential ◽  
The Brain ◽  
Synthesis And Degradation

Abstract The use of different natural and/or synthetic preparations of Cannabis sativa is associated with therapeutic strategies for many diseases. Indeed, thanks to the widespread diffusion of the cannabinoidergic system in the brain and in the peripheral districts, its stimulation, or inhibition, regulates many pathophysiological phenomena. In particular, central activation of the cannabinoidergic system modulates the limbic and mesolimbic response which leads to food craving. Moreover, cannabinoid agonists are able to reduce inflammatory response. In this review a brief history of cannabinoids and the protagonists of the endocannabinoidergic system, i.e. synthesis and degradation enzymes and main receptors, will be described. Furthermore, the pharmacological effects of cannabinoids will be outlined. An overview of the involvement of the endocannabinoidergic system in neuroinflammatory and metabolic pathologies will be made. Finally, particular attention will also be given to the new pharmacological entities acting on the two main receptors, cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2), with particular focus on the neuroinflammatory and metabolic mechanisms involved.

Fluid flow and faulting history of the Iano tectonic window (Southern Tuscany, Italy).

2021 ◽  
Author(s):  
Paolo Fulignati ◽  
Martina Zucchi ◽  
Andrea Brogi ◽  
Enrico Capezzuoli ◽  
Domenico Liotta ◽  
...  
Keyword(s):  
Fluid Inclusions ◽  
Hydrothermal Fluids ◽  
Normal Faults ◽  
High Angle ◽  
Quartz Veins ◽  
History Of ◽  
Tectonic Window ◽  
Liquid Vapor

<p>In the Iano area (Southern Tuscany) a small tectonic window of Tuscan metamorphic units is observed. This belongs to the northernmost part of the so-called Mid-Tuscan ridge and, during Pliocene, formed a submarine high, now defining the easternmost shoulder of the Volterra Pliocene basin. The area gives the opportunity to investigate the complete cycle of negative inversion from crustal thickening to crustal thinning, which characterizes Southern Tuscany. Our new data focus on the western margin of the Iano ridge, and in particular on a system of high angle normal faults that represents the youngest structures of the investigated area. These structures, deformed low angle regional detachments locally juxtaposing the uppermost units of contractional nappe stack (the ophiolite-bearing Ligurian units), with the Tuscan metamorphic units, with an almost complete excision of at least 3.5 Km thick Mesozoic to Tertiary Tuscan nappe succession. The high angle normal faults show variable Plio-Quaternary vertical displacements from few meters to about 500 meters, and acted as pathways for the upwelling of hydrothermal fluids, as revealed by Pleistocene travertine deposits, hydrothermal alteration and occurrence of different generations of fluid inclusions in hydrothermal veins associated with these fault systems. Fluid inclusions were studied in quartz veins hosted in the Verrucano metasediments forming the top of the Tuscan metamorphic unit, as well as in some carbonate lithotypes (Cretaceous to Tertiary in age) of the overlying Tuscan Nappe. Two different kinds of fluid inclusions were documented. The Type 1 are multiphase (liquid + vapor + 1 daughter mineral) liquid-rich fluid inclusions whereas the Type 2 are two-phase (liquid + vapor) liquid-rich fluid inclusions. Type 1 fluid inclusions are primary in origin and were found only in quartz veins present in Verrucano metarudites, whereas Type 2 fluid inclusions occur in quartz veins present in both Verrucano phyllites and quartzites and in the carbonate units of the Tuscan Nappe. These are secondary and can be furthermore distinguished in two sub-populations (Type 2a and Type 2b) on the basis of petrographic observation and microthermometric data. Fluid inclusion investigation evidenced an evolution of the hydrothermal fluids from relatively high-T (~265°C) and hypersaline (35 wt.% NaCl<sub>equiv.</sub>) fluids trapped at about 100 MPa, to lower temperature (~195°C) and salinity (~9.5 wt.% NaCl<sub>equiv.</sub>) fluids, having circulated in the high-angle fault system. Based on the new data and a revision of the local tectonic setting a fluid-rock interaction history has been reconstructed with new hints and constraints for the Plio-Quaternary extensional history of the Volterra basin.</p>

ORGANIZATION OF AMBULATORY CARE FOR TYPE 2 DIABETES MELLITUS

Vestnik ◽  
2021 ◽  
pp. 187-193
Author(s):  
З.К. Манатбекова ◽  
А. Озат ◽  
А.Е. Бектур ◽  
А.Р. Шаймерден ◽  
Д.А. Ахат ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Outpatient Care ◽  
Best Practice ◽  
Self Management ◽  
Order Sets ◽  
History Of ◽  
Insulin Use ◽  
Quality Assurance Standards

Качественная амбулаторная помощь при диабете требует как стандартов оказания амбулаторной помощи, часто обеспечиваемой структурированными наборами заказов, так и стандартов обеспечения качества для улучшения процессов. Протоколы, обзоры и руководства «передовой практики» непоследовательно применяются в больницах. Чтобы исправить это, в больницах установлены протоколы для структурированного ухода за пациентами и структурированные наборы заказов, которые включают компьютеризированный ввод заказов врача (CPOE). В первоначальных заказах должен быть указан тип диабета (например, диабет 1 или 2 типа) или отсутствие диабета в анамнезе. Поскольку стационарное использование инсулина и приказы о выписке могут быть более эффективными, если основаны на уровне A1C при поступлении, выполните тест A1C у всех пациентов с диабетом или гипергликемией, госпитализированных в больницу, если тест не был проведен. выполнено за предыдущие 3 месяца. Целью данной работы является рассмотрение стандартов амбулаторного лечения пациентов с диабетом 2 типа, составление рекомендации по поведению и формировании навыков в отношении самоконтроля при диабете. Quality ambulatory diabetes care requires both outpatient care standards, often provided by structured ordering, and quality assurance standards to improve processes. “Best practice” protocols, reviews and guidelines are inconsistently applied in hospitals. To remedy this, hospitals have established protocols for structured patient care and structured order sets that include computerized entry of physician orders (CPOE). Initial orders must indicate the type of diabetes (such as type 1 or 2 diabetes) or no history of diabetes. Because inpatient insulin use and discharge orders may be more effective if based on admission A1C levels, perform an A1C test on all diabetic or hyperglycemic patients admitted to the hospital if the test has not been performed. completed in the previous 3 months. The aim of this work is to review the standards of outpatient treatment of patients with type 2 diabetes, to draw up recommendations on behavior and skills formation in relation to self-management in diabetes.

Abstract P267: Burden of Disease Among Older Adults With Type 1 and Type 2 Diabetes: Results From the Study of Longevity in Diabetes (SOLID)

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Mary E Lacy ◽  
Paola Gilsanz ◽  
Chloe Eng ◽  
Michal S Beeri ◽  
Andrew J Karter ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Emergency Department ◽  
Functional Impairment ◽  
Coronary Bypass ◽  
Emergency Department Utilization ◽  
Geriatric Syndromes ◽  
History Of

Introduction: Increasing incidence of type 1 diabetes (T1D) coupled with increasing life expectancy have resulted in an unprecedented number of older adults living with T1D. However, little is known about the burden of aging and diabetes-related complications in this unique group. We hypothesized that older adults with T1D would have greater diabetes and aging-related burden compared to an age, sex, race/ethnicity, and education-matched group of older adults with type 2 diabetes (T2D). Methods: We compared the following characteristics by diabetes type among older adults (aged ≥60) with T1D (n=805) and T2D (n=249) from the Study of Longevity in Diabetes (SOLID) using chi-squared tests: diabetes history (age of onset, diabetes duration); diabetes-related complications (retinopathy, neuropathy, nephropathy, severe hypo- and hyperglycemia resulting in hospitalization/emergency department utilization), cardiovascular disease (stroke, MI, coronary bypass), and geriatric syndromes (depression, incontinence, memory problems and functional impairment). Results: Average age at diagnosis and duration of diabetes, respectively, were 28 years old and 40 years duration for T1D and 56 years old and 13 years duration for T2D (Table 1). Compared to T2D, participants with T1D were more likely to report history of retinopathy, neuropathy, nephropathy, lifetime hypo- and hyperglycemic events resulting in hospitalization/emergency department utilization, and history of a coronary bypass. By contrast, those with T2D were more likely to be incontinent and have functional impairment. Conclusions: Our results show that diabetes-related complications are more prevalent in those with T1D than in comparable adults with T2D, while certain geriatric syndromes were more prevalent in those with T2D. Older adults with T1D are a growing population with unique diabetes-specific and aging-related considerations. Additional research is needed to understand the interplay of aging and diabetes in this group to inform patient care .

scholarly journals Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin

2020 ◽  
Vol 11 ◽  
Author(s):  
Chun-Ting Lee ◽  
Keng-Shiang Huang ◽  
Jei-Fu Shaw ◽  
Jung-Ren Chen ◽  
Wen-Shuo Kuo ◽  
...  
Keyword(s):  
Ethyl Alcohol ◽  
Folk Medicine ◽  
Cordyceps Militaris ◽  
Pharmacological Effect ◽  
Immunomodulatory Effects ◽  
Comprehensive Understanding ◽  
Type 2 Immunity ◽  
History Of

Cordyceps militaris (C. militaris) is a fungus with a long history of widespread use in folk medicine, and its biological and medicinal functions are well studied. A crucial pharmacological effect of C. militaris is immunomodulation. In this review, we catalog the immunomodulatory effects of different extracts of C. militaris, namely total extracts, polysaccharides and cordycepin. Total extracts obtained using water or 50% ethyl alcohol and polysaccharides from C. militaris were discovered to tend to promote type 1 immunity, whereas total extracts obtained using 70–80% ethyl alcohol and cordycepin from C. militaris were more likely to promote type 2 immunity. This article is the first to classify the immunomodulatory effects of different extracts of C. militaris. In addition, we discovered a relationship between different segments or extracts and differing types of immunity. This review can provide the readers a comprehensive understanding on the immunomodulatory effects of the precious folk medicine and guidance on its use for both health people and those with an immunodeficiency.

INFERRING PHYLOGENETIC RELATIONSHIPS AVOIDING FORBIDDEN ROOTED TRIPLETS

2006 ◽  
Vol 04 (01) ◽  
pp. 59-74 ◽  
Author(s):  
YING-JUN HE ◽  
TRINH N. D. HUYNH ◽  
JESPER JANSSON ◽  
WING-KIN SUNG
Keyword(s):  
Approximation Algorithms ◽  
Phylogenetic Tree ◽  
Phylogenetic Trees ◽  
Evolutionary History ◽  
Phylogenetic Network ◽  
Evolutionary Relationships ◽  
Large Set ◽  
Tree Network ◽  
History Of ◽  
Overlapping Sets

To construct a phylogenetic tree or phylogenetic network for describing the evolutionary history of a set of species is a well-studied problem in computational biology. One previously proposed method to infer a phylogenetic tree/network for a large set of species is by merging a collection of known smaller phylogenetic trees on overlapping sets of species so that no (or as little as possible) branching information is lost. However, little work has been done so far on inferring a phylogenetic tree/network from a specified set of trees when in addition, certain evolutionary relationships among the species are known to be highly unlikely. In this paper, we consider the problem of constructing a phylogenetic tree/network which is consistent with all of the rooted triplets in a given set [Formula: see text] and none of the rooted triplets in another given set [Formula: see text]. Although NP-hard in the general case, we provide some efficient exact and approximation algorithms for a number of biologically meaningful variants of the problem.

FAMILY HISTORY OF DIABETES IS ASSOCIATED WITH INCREASED RISK OF RECURRENT DIABETIC KETOACIDOSIS IN PEDIATRIC PATIENTS

2020 ◽  
Vol 26 (3) ◽  
pp. 305-311
Author(s):  
Janaki D. Vakharia ◽  
Sungeeta Agrawal ◽  
Janine Molino ◽  
Lisa Swartz Topor
Keyword(s):  
Diabetes Mellitus ◽  
Family History ◽  
Diabetic Ketoacidosis ◽  
Pediatric Patients ◽  
Incidence Rate Ratio ◽  
Family History Of Diabetes ◽  
Increased Risk ◽  
History Of

Objective: To determine the relationship between family history of diabetes mellitus (DM) and diabetic ketoacidosis (DKA) recurrence in youth with established type 1 diabetes mellitus (T1DM). Methods: We performed a retrospective chart review of patients with DKA admitted to a pediatric hospital between January, 2009, and December, 2014. We compared patients with recurrent (≥2 admissions) and nonrecurrent DKA (1 admission) and investigated patient level factors, including family history, that may be associated with DKA recurrence in pediatric patients with established T1DM. Results: Of the 131 subjects in the study, 51 (39%) subjects were in the recurrence group. Age ≥15 years old, public health insurance, and family history of T1DM or type 2 diabetes mellitus were associated with recurrent DKA admissions in both univariable and multivariable analyses. Family history was associated with DKA recurrence, with an incidence rate ratio of 1.5 (95% confidence interval = 1.0 to 2.3; P = .03). The association was not explained by type of familial diabetes, first degree relative status, or whether the family member lived in the household. Conclusion: Recognition that a positive family history of DM may be associated with a higher risk for DKA recurrence in patients with established T1DM may allow for targeted education and focus on a previously unidentified population at increased risk for DKA. Understanding the mechanism underlying the effect of family history of diabetes on the rates of DKA in patients with established T1DM may allow for improved identification and education of patients who may be at risk for DKA recurrence. Abbreviations: CI = confidence interval; DKA = diabetic ketoacidosis; EHR = electronic health record; IBD = inflammatory bowel disease; IRR = incidence rate ratio; T1DM = type 1 diabetes mellitus; T2DM = type 2 diabetes mellitus

Sign in / Sign up

Export Citation Format

Share Document