scholarly journals Liver involvement in the process of acute respiratory infections in pediatric patients

2019 ◽  
Vol 13 (05.1) ◽  
pp. 063S-068S
Author(s):  
Nune Baghdasaryan ◽  
Gohar Ayvazyan ◽  
Murad Grigoryan ◽  
Lilit Avetisyan ◽  
Olya Asatryan ◽  
...  
Keyword(s):  
Disease Severity ◽  
Pediatric Patients ◽  
Respiratory Infections ◽  
Serum Levels ◽  
Underlying Disease ◽  
Liver Involvement ◽  
P Value ◽  
Specific Marker ◽  
Tnf Α ◽  
Severity Of The Disease

Introduction: We aimed to investigate the prevalence of liver involvement in pediatric patients with ARI using both routine tests of hepatic panel, and ornithine carbamoyltransferase (OCT) to identify the most sensitive indicators of early hepatic injury. Methodology: A prospective cohort study of 84 armenian children with ARI was conducted to evaluate the associated liver involvement. The diagnostic variables of interest were the signs of clinical disease severity, and enzymatic profile of the patients. Results: Serum levels of OCT were increased in 94% of patients versus routine tests of hepatic panel (AST in 41.7%, ALT in 15.5%, etc). Variance analysis by severity groups showed the serum levels of OCT (p < 0.001), ammonia (p < 0.001), phospholipides (p = 0.05), glucose (p = 0.01), TNF-α (p = 0.01), IL-8 (p < 0.001), AST (p < 0.001), and ALP (p < 0.001) were associated with the severity of underlying disease. Moreover, regression analysis revealed the serum activity of OCT (p value < 0.001, OR = 1.27) and ammonia (p value 0.002, OR = 1.1) significantly predict the severity of the disease. Conclusions: Using more sensitive marker of liver damage can detect more cases of ARI with hepatic manifestations. For evaluation of the liver involvement we are suggesting the testing of serum OCT levels as a more sensitive and specific marker. Pediatric patients with ARI and with higher serum OCT levels have 27% more chance to experience increased disease severity, which can affect on liver state and prolong hospitalization time and cost.

scholarly journals Serum Levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17, and IL-18 in Patients With Active Psoriasis and Correlation With Disease Severity

2005 ◽  
Vol 2005 (5) ◽  
pp. 273-279 ◽  
Author(s):  
Ozer Arican ◽  
Murat Aral ◽  
Sezai Sasmaz ◽  
Pinar Ciragil
Keyword(s):  
Disease Severity ◽  
Severity Index ◽  
Serum Levels ◽  
Clinical Severity ◽  
Mean Values ◽  
Tnf Α ◽  
Severity Of The Disease ◽  
Independent Marker ◽  
Immunomodulatory Therapies

Recent progress in the understanding of psoriasis has shown that the regulation of local and systemic cytokines plays an important role in its pathogenesis. The most often used psoriasis score is the psoriasis area and severity index (PASI). A simple laboratory test from a blood sample would be an attractive, patient-independent, and observer-independent marker of disease severity. To this end, we evaluated the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. The serum levels of cytokines levels were determined with the use of the ELISA method. All mean values except IL-17 levels of patients were significantly higher than those of controls. There was a significant correlation between serum levels of IFN-γ, IL-12, IL-17, and IL-18, and severity of the disease. Psoriasis can be described as a T-cell-mediated disease, with a complex role for a variety of cytokines, which has led to the development of new immunomodulatory therapies. In this study, serum TNF-α, IFN-γ, IL-6, IL-8, IL-12, and IL-18 levels were significantly higher in active psoriatic patients than in controls. Furthermore, high levels of IFN-γ, IL-12, and IL-18 correlated with the clinical severity and activity of psoriasis, and those measurements of serum levels of these cytokines may be objective parameters for the disease severity.

scholarly journals An inflammatory cytokine signature helps predict COVID-19 severity and death

2020 ◽  
Author(s):  
Diane Marie Del Valle ◽  
Seunghee Kim-schulze ◽  
Huang Hsin-hui ◽  
Noam D Beckmann ◽  
Sharon Nirenberg ◽  
...  
Keyword(s):  
New York ◽  
Disease Severity ◽  
Cox Regression ◽  
Predictive Biomarkers ◽  
Clinical Information ◽  
Serum Levels ◽  
The United States ◽  
High Serum ◽  
Laboratory Test Results ◽  
Tnf Α

The COVID-19 pandemic caused by infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to more than 100,000 deaths in the United States. Several studies have revealed that the hyper-inflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. However, predictive biomarkers of pathogenic inflammation to help guide targetable immune pathways are critically lacking. We implemented a rapid multiplex cytokine assay to measure serum IL-6, IL-8, TNF-α, and IL-1β in hospitalized COVID-19 patients upon admission to the Mount Sinai Health System in New York. Patients (n=1484) were followed up to 41 days (median 8 days) and clinical information, laboratory test results and patient outcomes were collected. In 244 patients, cytokine measurements were repeated over time, and effect of drugs could be assessed. Kaplan-Meier methods were used to compare survival by cytokine strata, followed by Cox regression models to evaluate the independent predictive value of baseline cytokines. We found that high serum IL-6, IL-8, and TNF-α levels at the time of hospitalization were strong and independent predictors of patient survival. Importantly, when adjusting for disease severity score, common laboratory inflammation markers, hypoxia and other vitals, demographics, and a range of comorbidities, IL-6 and TNF-α serum levels remained independent and significant predictors of disease severity and death. We propose that serum IL-6 and TNF-α levels should be considered in the management and treatment of COVID-19 patients to stratify prospective clinical trials, guide resource allocation and inform therapeutic options. We also propose that patients with high IL-6 and TNF-α levels should be assessed for combinatorial blockade of pathogenic inflammation in this disease.

scholarly journals THE MUCOSAL MICRORNA PROFILE RELATES TO AGE AND SEVERITY OF DISEASE IN PATIENTS WITH ULCERATIVE COLITIS

2021 ◽  
Vol 27 (Supplement_1) ◽  
pp. S11-S11
Author(s):  
Mikkel Malham ◽  
Jaslin James ◽  
Christian Jakobsen ◽  
Estrid Høgdall ◽  
Kim Holmstroem ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Disease Severity ◽  
Mirna Expression ◽  
Pediatric Patients ◽  
Severe Disease ◽  
Adult Patients ◽  
Expression Levels ◽  
Microrna Profile ◽  
Severity Of The Disease

Abstract Despite significant evidence that the expression of several microRNA’s (miRNA) impacts on disease activity in patients with ulcerative colitis (UC), it remains unknown if the more severe disease phenotype seen in pediatric-onset UC can be explained by altered miRNA expression. In this study, we aimed to assess the relationship between miRNA expression, age, and disease severity in pediatric and adult patients with UC. Using RT-qPCR, we analyzed the expression of miR-21, miR-31, miR-126, miR-142, and miR-155 in paraffin-embedded rectum biopsies from 30 pediatric and 30 adult-onset UC patients, and found that lesions from adult patients had significantly higher expression levels of miR-21 compared to pediatric patients and that the expression levels of miR-31 (all patients) and miR-155 (pediatric patients only) correlated inversely with histological assessed disease severity. Using in situ hybridization followed by image analysis, the expression estimates of miR-21 and miR-126 were found to correlate with histological assessed disease severity. In conclusion, we found that the expression of miRNAs depends on the age of the patient and/or the severity of the disease, suggesting that miRNAs may contribute to the regulation of inflammation in UC and could be useful biomarkers in the surveillance of disease severity.

scholarly journals Overview of SARS-CoV-2 Infection and Its Potential Reactions

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Esmaeil Mortaz ◽  
Neda K. Dezfuli
Keyword(s):  
Immune System ◽  
Current Knowledge ◽  
Serum Levels ◽  
The Body ◽  
Immune System Dysfunction ◽  
Pubmed Database ◽  
Tnf Α ◽  
Key Points ◽  
Severity Of The Disease ◽  
Review Current

Context: The immunopathology of SARS-CoV-2 infection in COVID-19 is not well described yet, especially regarding dysregulation of the immune system. In this mini-review, current knowledge about the SARS-CoV-2 infection and immunopathogenesis of COVID-19 disease is described. We also discuss possible induced reactions against SARS-COV-2. Evidence Acquisition: Based on the authors' experience and knowledge, the current review aimed to, firstly, discuss and overview SRAS-CoV-2 infection and reactions in the body, and, secondly, to obtain related subjects from the PubMed database. Results and Conclusion: In most COVID-19 patients, uncontrollable cytokines secretion and mediators are major key points in the pathogenesis of the disease. Of all cytokines and mediators, serum levels of IL-6, IL-1β, TNF-α, IL-8, and soluble TNF-α receptor (sTNFR) have been reported. Lymphopenia and hypoxia, as well as the severity of the disease, can be considered as COVID-19 manifestations. High levels of intracellular NO inside of the red blood cells (RBCs) of patients drive the unexpected silent hypoxia phenotype induced ARDS importantly related to the patient's immune system dysfunction.

scholarly journals EVALUATION OF SERUM ZINC LEVELS IN HOSPITALIZED CHILDREN WITH ACUTE RESPIRATORY INFECTIONS

2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Gurnoor Singh ◽  
Anand Kumar Bhardwaj ◽  
Gauri Chauhan ◽  
Vikramjot Singh
Keyword(s):  
Respiratory Infections ◽  
Serum Zinc ◽  
Serum Levels ◽  
P Value ◽  
Hospitalized Children ◽  
Acute Respiratory Infections ◽  
Immune Functions ◽  
National Immunization ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: ARI is the leading cause of mortality and a common cause of morbidity in children below 5 years. Zinc deficiency may increase the risk of respiratory tract infection. Zinc is thought to decrease susceptibility to acute lower respiratory infections by regulating various immune functions. The aim of study was to study serum zinc levels in hospitalized children with acute respiratory infections aged  2 month to  5 years. Material and Methods: Serum Zinc levels in a hundred children admitted with ARI were evaluated. Results and conclusion: Out of a hundred patients with ARI, 60% had below normal levels. Mean serum zinc levels were 70.27 +­­­ ­-­ 25.23 microgram/dl. Zinc levels in LARIs were significantly lower (P value<0.05) when compared to UARIs. There was no statistically significant correlation with age, gender, anemia and immunization status. Keywords: ARI, UARIs, LARIs, Zinc serum levels. Abbreviations: ARIs- Acute Respiratory Infections, UARIs- Upper Acute Respiratory Infections, LARIs- Lower Acute Respiratory Infections, NIS- National immunization Schedule 

scholarly journals CORRELATION BETWEEN SERUM C-REACTIVE PROTEIN LEVEL WITH SEVERITY OF THE DISEASE IN COVID-19 PATIENTS

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Sangeeta Gahlot ◽  
Surendra Yadav ◽  
Makkhan Lal Saini
Keyword(s):  
Severe Disease ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
P Value ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Group I ◽  
Moderate Disease ◽  
Severity Of The Disease

Background: To find the levels of serum CRP in confirmed Covid-19 patients and to compare their levels in patients with mild to moderate disease and patients with severe disease who required ICU care for management. Methods: A Cross sectional study was carried out on 100 confirmed cases of Covid-19, in whom Serum levels of Random sugar (RBS), Creatinine, Urea, C- reactive protein (CRP) were measured. Results: The levels of serum Urea, Creatinine were significantly increased in group II when compared to group 1, and the levels of CRP were significantly increased with p value <0.0001 in group IIwhen compared to group I. Conclusion: Findings of our study suggest that determination of biochemical parameters like CRP at the time of hospitalization helps in predicting the severity of disease and need for ICU for better treatment management and prevention of adverse outcome. Keywords: Severe acute respiratory syndrome, Covid-19, C- reactive protein, Intensive care unit.

Increased serum levels of TNF-α and decreased serum levels of IL-27 in patients with Parkinson disease and their correlation with disease severity

2018 ◽  
Vol 166 ◽  
pp. 76-79 ◽  
Author(s):  
Ebrahim Kouchaki ◽  
Reza Daneshvar Kakhaki ◽  
Omid Reza Tamtaji ◽  
Ehsan Dadgostar ◽  
Mohammad Behnam ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Disease Severity ◽  
Serum Levels ◽  
Tnf Α

Increases in serum levels of troponin I are associated with cardiac dysfunction and disease severity in pediatric patients with septic shock*

2004 ◽  
Vol 5 (6) ◽  
pp. 533-538 ◽  
Author(s):  
Kimberly E. Fenton ◽  
Craig A. Sable ◽  
Michael J. Bell ◽  
Kantilal M. Patel ◽  
John T. Berger
Keyword(s):  
Septic Shock ◽  
Disease Severity ◽  
Cardiac Dysfunction ◽  
Pediatric Patients ◽  
Troponin I ◽  
Serum Levels

scholarly journals Evaluation of maternal serum levels of cell adhesion molecules and endothelial inflammatory markers in normal pregnancy, gestational hypertension and pre-eclampsia

2017 ◽  
Vol 6 (6) ◽  
pp. 2231 ◽  
Author(s):  
Taru Gupta ◽  
Sarika Arora ◽  
Anil Kumar ◽  
Nupur Gupta ◽  
Sangeeta Gupta
Keyword(s):  
Inflammatory Mediators ◽  
Inflammatory Markers ◽  
Gestational Hypertension ◽  
Mode Of Delivery ◽  
Serum Levels ◽  
P Value ◽  
Vascular Cell ◽  
Hypertensive Disorders ◽  
Tnf Α ◽  
Cell Adhesions

Background: Hypertensive disorders complicate 5 to 10% of all pregnancies. Despite the still unexplained pathogenesis, endothelial dysfunctions and inflammatory mediators are thought to be responsible for the pathogenesis gestational hypertension and pre-eclampsia. Aims and objective of the study was to determine the serum levels of cell adhesions molecules - VCAM-1 and ICAM-1 and endothelial inflammatory markers TNF-α and homocysteine in normal pregnancies, Gestational Hypertension and in Pre-eclampsiaMethods: The cross-sectional study was carried out in Department of Obstetrics and Gynecology and Biochemistry, ESI-PGIMSR, New Delhi between October 2013-April 2015. 150 patients who gave informed written consent were enrolled and were divided equally in three groups of 50 each (normotensive, gestational hypertensive and pre-eclamptic patients). Three groups have been compared in terms of variables such as age, BMI, gestational age, systolic and diastolic blood pressure, platelet count, AST, ALT, mode of delivery, neonatal weight, VCAM-I, ICAM-I, homocysteine and TNF-alpha concentrations.Results: We found the higher concentrations of vascular cell adhesions molecules (VCAM-1 and ICAM-1) and inflammatory mediators (homocysteine and TNF α) in gestational hypertensive patients and in pre-eclamptic patients. Out of four markers, concentrations of ICAM-1 was found in largest proportions and it was also statistical significant. P value was <0.001. Though in our study concentration VCAM-1, homocysteine and TNF-α were also high in gestational hypertensive groups as compared with normotensive patients, but they were not statistical significant.Conclusions: We conclude that higher concentrations of vascular cell adhesions molecules and inflammatory mediators may be responsible for hypertensive disorders of pregnancy suggesting the role of endothelial dysfunction as a central pathogenic feature in development of preeclampsia.

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