scholarly journals Influenza A (H1N1)-associated severe complications; hemolytic uremic syndrome, myocarditis, acute necrotizing encephalopathy

2019 ◽  
Vol 13 (01) ◽  
pp. 83-86 ◽  
Author(s):  
Sevliya Öcal Demir ◽  
Serkan Atıcı ◽  
Eda Kepenekli Kadayifci ◽  
Gülşen Akkoç ◽  
Nurhayat Yakut ◽  
...  
Keyword(s):  
Renal Failure ◽  
Hemolytic Uremic Syndrome ◽  
Influenza A ◽  
Antiviral Treatment ◽  
Supportive Treatment ◽  
H1n1 Infection ◽  
Acute Necrotizing Encephalopathy ◽  
Influenza A H1n1 ◽  
Acute Necrotizing ◽  
Uremic Syndrome

Influenza is a generally self-limited infection agent that only rarely causes severe complications. To increase awareness about its serious complications, we report three cases of influenza A (H1N1) infection complicated with hemolytic uremic syndrome, myocarditis and acute necrotizing encephalopathy. In all three cases, nasopharyngeal samples confirmed influenza A (H1N1) infection by antigen test and multiplex PCR detection. The first case, a 3-year-old girl, had respiratory distress, anemia, thrombocytopenia and renal failure at admission, and was diagnosed with hemolytic uremic syndrome. Supportive treatment and oseltamivir did not prevent the development of chronic renal failure. The second case, a 5-year-old girl admitted with lethargia and flu-like symtoms and was diagnosed with myocarditis and cardiogenic shock. Oseltamivir and supportive treatment including extra-corporeal membrane oxygenation (ECMO) failed. She died on the 3rd day of admission. The third case, a 21-month-old boy, presented with decreased level of consciousness and was diagnosed with acute necrotizing encephalopathy with the aid of cranial magnetic resonance imagining (MRI). He was discharged without any neurological sequelae three weeks after admission. It should be kept in mind that influenza virus does not always cause a self-limited flu. Multidisciplinary management, early diagnosis and antiviral treatment are critical for the disease and to prevent its life-threatening complications.

Acute Encephalitis Syndrome with an Unusual Diagnosis

2019 ◽  
Vol 66 (2) ◽  
pp. 228-230
Author(s):  
Mili Thomas ◽  
Kamala Swarnam ◽  
Gopika Sekhar Remadevi ◽  
A Marthanda Pillai
Keyword(s):  
Influenza A ◽  
Rare Complication ◽  
Normal Liver ◽  
Acute Onset ◽  
High Rate ◽  
H1n1 Infection ◽  
Acute Necrotizing Encephalopathy ◽  
Influenza A H1n1 ◽  
Acute Necrotizing ◽  
Intravenous Steroids

Abstract Four-year old boy was admitted with acute onset of fever with seizures and altered sensorium. His mother had history of contact with influenza A H1N1 virus (H1N1) infection. Blood counts, electrolytes, blood sugar and ammonia were normal. Liver enzymes were mildly elevated. CSF study showed elevated protein, normal sugar and no pleocytosis. Cerebrospinal fluid (CSF) viral panel was negative. Magnetic resonance imaging brain was suggestive of acute necrotizing encephalopathy. His throat swab and sputum polymerase chain reaction was positive for H1N1. He was managed with ventilation, intravenous steroids and other supportive measures. At discharge his sensorium improved but had neurological sequelae. We are presenting this case as this is a very rare complication of H1N1 infection with high rate of mortality. Early supportive measures and steroids/intravenous immunoglobulin may save the patient.

Hemolytic uremic syndrome associated with novel influenza A H1N1 infection

2010 ◽  
Vol 26 (1) ◽  
pp. 149-150 ◽  
Author(s):  
Emilija Golubovic ◽  
Predrag Miljkovic ◽  
Sasa Zivic ◽  
Danijela Jovancic ◽  
Gordana Kostic
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Influenza A ◽  
H1n1 Infection ◽  
Influenza A H1n1 ◽  
Uremic Syndrome ◽  
Novel Influenza A

scholarly journals EPIDEMIOLOGI DAN DIAGNOSIS KEDOKTERAN LABORATORIK INFEKSI VIRUS H1N1

2018 ◽  
Vol 16 (3) ◽  
pp. 140
Author(s):  
J Sembiring ◽  
O Sianipar
Keyword(s):  
Sore Throat ◽  
Influenza A ◽  
Clinical Symptoms ◽  
H1n1 Virus ◽  
Antiviral Treatment ◽  
H1n1 Infection ◽  
Rt Pcr ◽  
Virus Family ◽  
Infection Diagnosis ◽  
Influenza A H1n1

H1N1 virus is an influenza virus family orthomyxoviridae, which clinical symptoms consist of: fever, cough, sore throat and headache. The virus can spread from person to person through airborne droplets and so a good infection control in the community or in healthworkers is needed, for instance by washing hands properly and PPE (Personal Protective Equipment). In October 4, 2009 there were over375.000 reported cases in which 4500 people were died. On June 11, 2009 the WHO stairs announced that H1N1 is the first pandemicin the 21st century. (The Indonesia people province was infecting by H1N1with 20 deaths until August 5, 2009). The purpose of thisarticle is to find out the epidemiological aspects as well as the diagnosis of influenza A H1N1 virus. From the website was found about1.110.000 sources, and after downloading them are selected as they are written only in the bibliography. From the searched informationobtained, it was known that H1N1 infection diagnosis begins with the discovery of heat (temperature ≥ 100° F [37.8° C]) and cough or sore throat. No cause other than influenza that is called with ILI was found. The informed laboratory examination is divided into three parts are confirmed if ILI was found as well as the virus in the throat or nasal swab by RT-PCR and/or virus culture; probably the ILIhas positive results of influenza A RT-PCR, but if the results are negative including the laboratorial findings, the basis of epidemiologyin this case was only suspected. Laboratory plays an important role in the establishing of the H1N1 infection diagnosis Rapid diagnosisis important to reduce infection, to protect patients from complications by antiviral treatment in the right time and also to provideimmediate information for the public.

scholarly journals Hemolytic uremic syndrome complicated by acute necrotizing encephalopathy of childhood

2009 ◽  
Vol 22 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Atsuhiro Yanagisawa ◽  
Takehiko Inui ◽  
Yoshiyuki Namai ◽  
Junichi Takanashi ◽  
Katsunori Fujii ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Acute Necrotizing Encephalopathy ◽  
Acute Necrotizing ◽  
Uremic Syndrome

scholarly journals Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1)

Renal Failure ◽  
2010 ◽  
Vol 32 (6) ◽  
pp. 753-756 ◽  
Author(s):  
Diogo Bento ◽  
Joana Mapril ◽  
Carla Rocha ◽  
Kevin J. Marchbank ◽  
David Kavanagh ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Influenza A ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Influenza A H1n1 ◽  
Uremic Syndrome

scholarly journals Case series: coronavirus disease 2019 infection as a precipitant of atypical hemolytic uremic syndrome: two case reports

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Christine J. Kurian ◽  
Zachary French ◽  
Patrick Kukulich ◽  
Matthew Lankiewicz ◽  
Sushil Ghimire ◽  
...  
Keyword(s):  
Renal Failure ◽  
Hemolytic Uremic Syndrome ◽  
Thrombotic Microangiopathy ◽  
Influenza A ◽  
Case Reports ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Case Series ◽  
Oliguric Renal Failure ◽  
History Of ◽  
Uremic Syndrome

Abstract Background Atypical hemolytic uremic syndrome is an exceedingly rare thrombotic microangiopathy caused by accelerated activation of the alternative complement pathway. Case presentation Here, we report two cases of patients presenting with suspected atypical hemolytic uremic syndrome precipitated by coronavirus disease 2019 infection. The first patient, a 25-year-old Hispanic male, had one prior episode of thrombotic microangiopathy presumed to be atypical hemolytic uremic syndrome precipitated by influenza A, and re-presented with thrombocytopenia, microangiopathic hemolytic anemia, nonoliguric renal failure, and normal ADAMTS13 activity, with confirmed coronavirus disease 2019 positivity. The second patient, a 31-year-old Caucasian female, had no personal history of thrombotic microangiopathy, though reported a family history of suspected atypical hemolytic uremic syndrome. She presented with similar laboratory derangements, oliguric renal failure requiring hemodialysis, and confirmed coronavirus disease 2019 positivity. Both patients were treated with eculizumab with complete resolution of their hematologic and renal complications. Conclusion To our knowledge, this represents the largest case series of atypical hemolytic uremic syndrome precipitated by coronavirus disease 2019 in adults.

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