mrskn7, a putative response regulator gene of Monascus ruber M7, is involved in oxidative stress response, development, and mycotoxin production

Mycologia ◽  
2016 ◽  
Vol 108 (5) ◽  
pp. 851-859 ◽  
Author(s):  
Yanchun Shao ◽  
Sha Yang ◽  
Zhouwei Zhang ◽  
Youxiang Zhou ◽  
Fusheng Chen
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Response Regulator ◽  
Oxidative Stress Response ◽  
Regulator Gene ◽  
Monascus Ruber ◽  
Mycotoxin Production

scholarly journals Regulation of Oxidative Stress Response by CosR, an Essential Response Regulator in Campylobacter jejuni

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22300 ◽  
Author(s):  
Sunyoung Hwang ◽  
Minkyeong Kim ◽  
Sangryeol Ryu ◽  
Byeonghwa Jeon
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Campylobacter Jejuni ◽  
Response Regulator ◽  
Oxidative Stress Response

scholarly journals High Fructose Negatively Impacts Proliferation of NSC-34 Motor Neuron Cell Line

2022 ◽  
Author(s):  
Divya Lodha ◽  
Jamuna R. Subramaniam
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Motor Neuron ◽  
Cell Line ◽  
Motor Neurons ◽  
Response Regulator ◽  
Oxidative Stress Response ◽  
Ros Generation ◽  
Multinucleated Cells ◽  
High Fructose

Abstract Objectives The main aim of this study is to identify the deleterious effects of indiscriminately consumed high fructose on motor neurons that are critically affected in many neurological conditions causing movement disorders including paralysis. Materials and Methods Neuroblastoma x mouse spinal cord motor neuron cell line (NSC-34) motor neuron cell lines were treated with high fructose and oxygen supplementation (18.8%) and assayed for cell proliferation/death, reactive oxygen species (ROS) generation, and oxidative stress response induction Statistical Analysis Mean and standard deviation, significance with and without high fructose (F)-5%, were estimated by t-tests using GraphPad Prism ver. 8.2.1 Results F-5% along with O2 (18.8%) annihilates the cells (∼85%) by day10 and inhibits cell division as observed by the presence of multinucleated cells. Unexpectedly, 1 to 2% of cells that survived, differentiated and displayed progressive neurite extension. Though not healthy, they were viable up to 80 days. F-5% increased ROS levels (∼34%) not accompanied by concomitant enhanced expression of oxidative stress response regulator, the transcription factor, nrf-2, or downstream effector, sod-1. Conclusion High fructose is extremely harmful to NSC-34 motor neuron cell line.

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