Reduced Toll-like receptor-9 expression on peripheral CD14+ monocytes of chronic hepatitis B patients and its restoration by effective therapy

2014 ◽  
Vol 19 (7) ◽  
pp. 637-643 ◽  
Author(s):  
Yi-Wen Huang ◽  
Cheng-Kai Hsu ◽  
Shih-Chang Lin ◽  
Shu-Chen Wei ◽  
Jui-Ting Hu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Effective Therapy ◽  
Toll Like Receptor

scholarly journals Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein

Hepatology ◽  
2006 ◽  
Vol 45 (1) ◽  
pp. 102-110 ◽  
Author(s):  
Kumar Visvanathan ◽  
Narelle A. Skinner ◽  
Alex J.V. Thompson ◽  
Stephen M. Riordan ◽  
Vitini Sozzi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

77 VIRAL LOADS CORRELATE WITH MILD SUPPRESSION OF THE TOLL-LIKE RECEPTOR SIGNALING IN THE LIVER OF CHRONIC HEPATITIS B PATIENTS

2009 ◽  
Vol 50 ◽  
pp. S32
Author(s):  
J.-H. Bockmann ◽  
M. Lütgehetmann ◽  
T. Volz ◽  
A. Köpke ◽  
A.W. Lohse ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Receptor Signaling ◽  
Toll Like Receptor ◽  
Viral Loads

In vitro Immunomodulatory Activity of Oxymatrine on Toll-Like Receptor 9 Signal Pathway in Chronic Hepatitis B

2014 ◽  
Vol 42 (06) ◽  
pp. 1399-1410 ◽  
Author(s):  
Ning Yao ◽  
Xin Wang
Keyword(s):  
Signal Transduction ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Signal Pathway ◽  
Immunomodulatory Activity ◽  
Toll Like Receptor ◽  
Peripheral Lymphocytes ◽  
Tlr9 Ligand

Oxymatrine, extracted from the herb Sophora alopecuraides L., was investigated to determine its anti-HBV immunomodulatory mechanism in vitro. Human peripheral lymphocytes were isolated from heparinized whole blood from 48 chronic hepatitis B (CHB) patients. The lymphocytes from each patient were divided into two groups according to pretreatment or no pretreatment with Oxymatrine in vitro. We examined the changes of expression and function of the toll-like receptor 9 (TLR9) signal transduction pathway in the peripheral lymphocytes with different treatment methods and investigated the synergism of Oxymatrine and the TLR9 ligand on antiviral cytokine secretions in vitro. The data showed Oxymatrine could induce antiviral cytokine secretions directly from the peripheral lymphocytes. For the TLR9 signal pathway, Oxymatrine not only augmented the expressions of TLR9 signal transduction molecules, but also activated the TLR9 signal function. This study has clearly demonstrated that TLR9 ligand could stimulate peripheral lymphocytes that have been pretreated with Oxymatrine. Furthermore, the quantity of antiviral cytokines secreted by the pretreated lymphocytes was greater than that of those without pretreatment. The interaction between the Oxymatrine and the TLR9 ligand appears to be synergistic. This study suggests Oxymatrine could be a strong immunomodulator, influence TLR9 signaling transduction, and synergistically improve the immune efficacy of the TLR9 ligand against CHB.

scholarly journals Association of toll-like receptor 3 polymorphism with chronic hepatitis B

2014 ◽  
Vol 21 ◽  
pp. 446
Author(s):  
E. Firat Goktas ◽  
C. Bulut ◽  
M.T. Goktas ◽  
S. Kinikli ◽  
A.P. Demiroz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Toll Like Receptor
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