In Vitro Immunomodulatory Activity of Interferon Alpha on Toll-Like Receptor 9 Signaling Pathway in Chronic Hepatitis B

2015 ◽  
Vol 35 (5) ◽  
pp. 385-391 ◽  
Author(s):  
Xin Wang ◽  
Ying-Ren Zhao ◽  
Hong-Li Liu ◽  
Xiao-Hua Ma ◽  
Yu Zhang
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Signaling Pathway ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Immunomodulatory Activity ◽  
Toll Like Receptor

In vitro Immunomodulatory Activity of Oxymatrine on Toll-Like Receptor 9 Signal Pathway in Chronic Hepatitis B

2014 ◽  
Vol 42 (06) ◽  
pp. 1399-1410 ◽  
Author(s):  
Ning Yao ◽  
Xin Wang
Keyword(s):  
Signal Transduction ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Signal Pathway ◽  
Immunomodulatory Activity ◽  
Toll Like Receptor ◽  
Peripheral Lymphocytes ◽  
Tlr9 Ligand

Oxymatrine, extracted from the herb Sophora alopecuraides L., was investigated to determine its anti-HBV immunomodulatory mechanism in vitro. Human peripheral lymphocytes were isolated from heparinized whole blood from 48 chronic hepatitis B (CHB) patients. The lymphocytes from each patient were divided into two groups according to pretreatment or no pretreatment with Oxymatrine in vitro. We examined the changes of expression and function of the toll-like receptor 9 (TLR9) signal transduction pathway in the peripheral lymphocytes with different treatment methods and investigated the synergism of Oxymatrine and the TLR9 ligand on antiviral cytokine secretions in vitro. The data showed Oxymatrine could induce antiviral cytokine secretions directly from the peripheral lymphocytes. For the TLR9 signal pathway, Oxymatrine not only augmented the expressions of TLR9 signal transduction molecules, but also activated the TLR9 signal function. This study has clearly demonstrated that TLR9 ligand could stimulate peripheral lymphocytes that have been pretreated with Oxymatrine. Furthermore, the quantity of antiviral cytokines secreted by the pretreated lymphocytes was greater than that of those without pretreatment. The interaction between the Oxymatrine and the TLR9 ligand appears to be synergistic. This study suggests Oxymatrine could be a strong immunomodulator, influence TLR9 signaling transduction, and synergistically improve the immune efficacy of the TLR9 ligand against CHB.

Low pretreatment serum HBsAg level and viral mutations as predictors of response to PEG-interferon alpha-2b therapy in chronic hepatitis B

2009 ◽  
Vol 46 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Pisit Tangkijvanich ◽  
Piyawat Komolmit ◽  
Varocha Mahachai ◽  
Pattaratida Sa-nguanmoo ◽  
Apiradee Theamboonlers ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Hbsag Level ◽  
Interferon Alpha 2B ◽  
Serum Hbsag ◽  
Predictors Of Response ◽  
Serum Hbsag Level ◽  
Pretreatment Serum

Interferon-alpha therapy in chronic hepatitis B

1999 ◽  
Vol 11 (12) ◽  
pp. A93
Author(s):  
H. L.A. Janssen ◽  
R. A. Heijtink ◽  
W. C.J. Hop ◽  
A. D.M.E. Osterhaus ◽  
S. W. Schalm
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Interferon Alpha Therapy ◽  
Alpha Therapy

Long-Term Results of Interferon Alpha Monotherapy in Patients with HBeAg-Negative Chronic Hepatitis B

2007 ◽  
Vol 52 (3) ◽  
pp. 727-731 ◽  
Author(s):  
Sabahattin Kaymakoglu ◽  
Ahmet Danalioglu ◽  
Kadir Demir ◽  
Cetin Karaca ◽  
Filiz Akyuz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Long Term Results ◽  
Negative Chronic Hepatitis
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