scholarly journals Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?

2010 ◽  
Vol 15 (7) ◽  
pp. 975-983 ◽  
Author(s):  
Alexander Jetter ◽  
Gerd Fätkenheuer ◽  
Dorothee Frank ◽  
Tobias Klaassen ◽  
Angela Seeringer ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Healthy Volunteers ◽  
P Glycoprotein ◽  
Cyp 3A

scholarly journals Safety of the Geneva Cocktail, a Cytochrome P450 and P-Glycoprotein Phenotyping Cocktail, in Healthy Volunteers from Three Different Geographic Origins

Drug Safety ◽  
2020 ◽  
Vol 43 (11) ◽  
pp. 1181-1189
Author(s):  
Victoria Rollason ◽  
Médéric Mouterde ◽  
Youssef Daali ◽  
Martina Čížková ◽  
Edita Priehodová ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Healthy Volunteers ◽  
P Glycoprotein ◽  
Geographic Origins

scholarly journals Influence ofPanax ginsengon Cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) Activity in Healthy Participants

2012 ◽  
Vol 52 (6) ◽  
pp. 932-939 ◽  
Author(s):  
Christine Y. Malati ◽  
Sarah M. Robertson ◽  
Jennifer D. Hunt ◽  
Cheryl Chairez ◽  
Raul M. Alfaro ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Glycoprotein P ◽  
P Glycoprotein ◽  
Cyp 3A ◽  
Healthy Participants

scholarly journals Effect of Red Ginseng on cytochrome P450 and P-glycoprotein activities in healthy volunteers

2016 ◽  
Vol 40 (4) ◽  
pp. 375-381 ◽  
Author(s):  
Dal-Sik Kim ◽  
Yunjeong Kim ◽  
Ji-Young Jeon ◽  
Min-Gul Kim
Keyword(s):  
Cytochrome P450 ◽  
Healthy Volunteers ◽  
Red Ginseng ◽  
P Glycoprotein

scholarly journals In Vivo Effects of Cyclosporin A and Ketoconazole on the Pharmacokinetics of Representative Substrates for P-Glycoprotein and Cytochrome P450 (CYP) 3A in Rats

2005 ◽  
Vol 28 (2) ◽  
pp. 316-322 ◽  
Author(s):  
Michiharu Kageyama ◽  
Hitomi Namiki ◽  
Hiroto Fukushima ◽  
Yukako Ito ◽  
Nobuhito Shibata ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cyclosporin A ◽  
P Glycoprotein ◽  
In Vivo Effects ◽  
Cyp 3A

Pharmacogenetics of Clozapine: In Vivo Role of Cytochrome P450 Isoforms and P-Glycoprotein

2008 ◽  
Vol 41 (05) ◽  
Author(s):  
E Jaquenoud-Sirot ◽  
B Knezevic ◽  
G Perla Morena ◽  
P Baumann ◽  
CB Eap
Keyword(s):  
Cytochrome P450 ◽  
P Glycoprotein ◽  
Cytochrome P450 Isoforms

scholarly journals Human Biodistribution and Radiation Dosimetry of the P-Glycoprotein Radiotracer [11C]Metoclopramide

2021 ◽  
Author(s):  
Martin Bauer ◽  
Sandra Barna ◽  
Matthias Blaickner ◽  
Konstantin Prosenz ◽  
Karsten Bamminger ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Healthy Volunteers ◽  
Effective Dose ◽  
Left Kidney ◽  
Whole Body ◽  
Red Bone Marrow ◽  
Body Distribution ◽  
P Glycoprotein ◽  
Pet Tracer ◽  
Male Subjects

Abstract Purpose To assess in healthy volunteers the whole-body distribution and dosimetry of [11C]metoclopramide, a new positron emission tomography (PET) tracer to measure P-glycoprotein activity at the blood-brain barrier. Procedures Ten healthy volunteers (five women, five men) were intravenously injected with 387 ± 49 MBq of [11C]metoclopramide after low dose CT scans and were then imaged by whole-body PET scans from head to upper thigh over approximately 70 min. Ten source organs (brain, thyroid gland, right lung, myocardium, liver, gall bladder, left kidney, red bone marrow, muscle and the contents of the urinary bladder) were manually delineated on whole-body images. Absorbed doses were calculated with QDOSE (ABX-CRO) using the integrated IDAC-Dose 2.1 module. Results The majority of the administered dose of [11C]metoclopramide was taken up into the liver followed by urinary excretion and, to a smaller extent, biliary excretion of radioactivity. The mean effective dose of [11C]metoclopramide was 1.69 ± 0.26 μSv/MBq for female subjects and 1.55 ± 0.07 μSv/MBq for male subjects. The two organs receiving the highest radiation doses were the urinary bladder (10.81 ± 0.23 μGy/MBq and 8.78 ± 0.89 μGy/MBq) and the liver (6.80 ± 0.78 μGy/MBq and 4.91 ± 0.74 μGy/MBq) for female and male subjects, respectively. Conclusions [11C]Metoclopramide showed predominantly renal excretion, and is safe and well tolerated in healthy adults. The effective dose of [11C]metoclopramide was comparable to other 11C-labeled PET tracers.

Physiological regulation of P-glycoprotein, MRP1, MRP2 and cytochrome P450 3A2 during rat ontogeny

2003 ◽  
Vol 45 (4) ◽  
pp. 377-387 ◽  
Author(s):  
Anna Rosati ◽  
Silvia Maniori ◽  
Giuliana Decorti ◽  
Luigi Candussio ◽  
Tullio Giraldi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Physiological Regulation ◽  
P Glycoprotein

scholarly journals Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers

2016 ◽  
Vol 31 (2) ◽  
pp. 107-116 ◽  
Author(s):  
Doo-Yeoun Cho ◽  
Joan H.Q. Shen ◽  
Suzanne M. Lemler ◽  
Todd C. Skaar ◽  
Lang Li ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Healthy Volunteers
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