scholarly journals In Vivo Effects of Cyclosporin A and Ketoconazole on the Pharmacokinetics of Representative Substrates for P-Glycoprotein and Cytochrome P450 (CYP) 3A in Rats

2005 ◽  
Vol 28 (2) ◽  
pp. 316-322 ◽  
Author(s):  
Michiharu Kageyama ◽  
Hitomi Namiki ◽  
Hiroto Fukushima ◽  
Yukako Ito ◽  
Nobuhito Shibata ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cyclosporin A ◽  
P Glycoprotein ◽  
In Vivo Effects ◽  
Cyp 3A

Pharmacogenetics of Clozapine: In Vivo Role of Cytochrome P450 Isoforms and P-Glycoprotein

2008 ◽  
Vol 41 (05) ◽  
Author(s):  
E Jaquenoud-Sirot ◽  
B Knezevic ◽  
G Perla Morena ◽  
P Baumann ◽  
CB Eap
Keyword(s):  
Cytochrome P450 ◽  
P Glycoprotein ◽  
Cytochrome P450 Isoforms

scholarly journals Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?

2010 ◽  
Vol 15 (7) ◽  
pp. 975-983 ◽  
Author(s):  
Alexander Jetter ◽  
Gerd Fätkenheuer ◽  
Dorothee Frank ◽  
Tobias Klaassen ◽  
Angela Seeringer ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Healthy Volunteers ◽  
P Glycoprotein ◽  
Cyp 3A

scholarly journals Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Hyun-Jong Cho ◽  
In-Soo Yoon
Keyword(s):  
Cytochrome P450 ◽  
Glycoprotein P ◽  
Metabolizing Enzymes ◽  
Herbal Products ◽  
P Glycoprotein ◽  
Concurrent Use ◽  
Substrate Drug ◽  
And Function

The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade. Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively. Thus, a summary of knowledge on the modulation of CYP and P-gp by commonly used herbs can provide robust fundamentals for optimizing CYP and/or P-gp substrate drug-based therapy. Herein, we review ten popular medicinal and/or dietary herbs as perpetrators of CYP- and P-gp-mediated pharmacokinetic herb-drug interactions. The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in severalin vitroandin vivoanimal and human systems.

Sertraline does not inhibit cytochrome P450 (CYP) 3A-mediated drug metabolism in vivo

1997 ◽  
Vol 42 (1) ◽  
pp. 45S ◽  
Author(s):  
S.H. Preskorn ◽  
J.A. Alderman ◽  
D.J. Greenblatt ◽  
D. Horst
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cyp 3A

scholarly journals Anti-Trypanosoma cruzieffects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins

Parasitology ◽  
2007 ◽  
Vol 135 (2) ◽  
pp. 217-228 ◽  
Author(s):  
J. BÚA ◽  
L. E. FICHERA ◽  
A. G. FUCHS ◽  
M. POTENZA ◽  
M. DUBIN ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Mammalian Cells ◽  
Isomerase Activity ◽  
P Glycoprotein ◽  
Demethylase Activity ◽  
Target Molecules ◽  
Intracellular Amastigote

SUMMARYCyclophilins are target molecules for cyclosporin A (CsA), an immunosuppressive antimicrobial drug. We have previously reported thein vitroanti-Trypanosoma cruziactivity of H-7-94 and F-7-62 non-immunosuppressive CsA analogues. In this work, we continue the study of the parasiticidal effect of H-7-94 and F-7-62 CsA analoguesin vitroandin vivoand we analyse 3 new CsA derivatives: MeIle-4-CsA (NIM 811), MeVal-4-CsA (MeVal-4) and D-MeAla-3-EtVal-4-CsA, (EtVal-4). The most efficient anti-T. cruzieffect was observed with H-7-94, F-7-62 and MeVal-4 CsA analogues evidenced as inhibition of epimastigote proliferation, trypomastigote penetration, intracellular amastigote development andin vivo T. cruziinfection. This trypanocidal activity could be due to inhibition of the peptidyl prolylcis-transisomerase activity on theT. cruzirecombinant cyclophilins tested. Furthermore, CsA and F-7-62 derivative inhibited the efflux of rhodamine 123 fromT. cruziepimastigotes, suggesting an interference with a P-glycoprotein activity. Moreover, H-7-94 and F-7-62 CsA analogues were not toxic as shown by cell viability and by aminopyrine-N-demethylase activity on mammalian cells. Our results show that H-7-94, F-7-62 and MeVal-4 CsA analogues expressed the highest inhibiting effects onT. cruzi, being promissory parasiticidal drugs worthy of further studies.

scholarly journals Influence ofPanax ginsengon Cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) Activity in Healthy Participants

2012 ◽  
Vol 52 (6) ◽  
pp. 932-939 ◽  
Author(s):  
Christine Y. Malati ◽  
Sarah M. Robertson ◽  
Jennifer D. Hunt ◽  
Cheryl Chairez ◽  
Raul M. Alfaro ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Glycoprotein P ◽  
P Glycoprotein ◽  
Cyp 3A ◽  
Healthy Participants
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