scholarly journals General anesthetics in children: neurotoxic or neuroprotective?

10.3823/2285 ◽  
2017 ◽  
Vol 10 ◽  
Author(s):  
Jéssica Farias Rebouças ◽  
Gylmara Bezerra de Menezes Silveira ◽  
Maria de Fátima Vasques Monteiro ◽  
Sara Araújo de Morais ◽  
Hermes Melo Teixeira Batista
Keyword(s):  
Cognitive Impairment ◽  
Learning Disorders ◽  
General Anesthetics ◽  
Experimental Animals ◽  
Multiple Exposures ◽  
Behavior Disabilities ◽  
The Family ◽  
Neurotoxic Effects ◽  
And Behavior ◽  
Ischemic Events

Introduction: general anesthetics are involved in neuroprotection in adults after ischemic events and cognitive impairment, thus, they also may be associated with learning disorders in children exposed to them before three years of age. Objective: Describe about the neurotoxic effects of general anesthetics in experimental animals and children. Method: This is a systematic review, performed from search in databases and on PubMed using the keywords "neurotoxicity" and "general anesthetics," and "general anesthetics," "neurotoxicity", "children", "young child "and" pediatric ". Results: The search resulted in 185 articles. Out of these, 78 met our inclusion criteria. We found that there was a significant evidence of neurotoxicity induced by general anesthetics in experimental animals that were just born, resulting in late and permanent cognitive deficits. This effect was associated with multiple exposures, exposure length of time and combination of drugs. However, some studies found cognitive impairment after a single exposure to anesthetic. Conclusion: There is insufficient evidence to state that general anesthetics are neurotoxic and have the potential to trigger learning and behavior disabilities in children. However, we suggest caution in indicating surgery in children under three years old, analyzing risk-benefit and inserting the family in the decision process.

Working with Sexual-Minority Individuals

2010 ◽  
pp. 837-868 ◽  
Author(s):  
Lisa M. Diamond ◽  
Molly R. Butterworth ◽  
Ritch C. Savin-Williams
Keyword(s):  
Identity Development ◽  
Sexual Minority ◽  
Minority Stress ◽  
Sexual Minorities ◽  
Minority Population ◽  
Same Sex ◽  
Psychological Issues ◽  
The Family ◽  
And Behavior ◽  
Oriented Research

The present chapter provides a review of some of the primary psychological issues confronting sexual minorities (i.e., individuals with same-sex attractions and relationships). Our goal is to provide a flexible set of preliminary questions that can be used to help sexual-minority clients to articulate their own idiosyncratic experiences and give voice to their own unique needs. We begin by addressing two of the most common and important clinical issues faced by sexual minorities: generalized “minority stress” and acceptance and validation from the family of origin. We then turn attention to the vast—and vastly underinvestigated—population of individuals with bisexual attractions and behavior, who actually constitute the majority of the sexual-minority population, despite having been systematically excluded from most prior research. We review the increasing body of research suggesting that individuals with bisexual patterns of attraction and behavior actually face greater mental health risks than those with exclusive same-sex attractions and behavior, and we explore potential processes and mechanisms underlying this phenomenon, focusing particular attention on issues of identity development and transition over the life span. We conclude by outlining a number of areas for future clinically oriented research.

Digital Pollution and Its Impact on the Family and Social Interactions

2021 ◽  
pp. 0192513X2098555
Author(s):  
Shiv Ratan Agrawal
Keyword(s):  
Social Interaction ◽  
Social Interactions ◽  
Critical Dimensions ◽  
Digital Devices ◽  
The Family ◽  
Negative Effect ◽  
Potential Negative Effect ◽  
Human Attitude ◽  
Impact On Family ◽  
And Behavior

The present study was an attempt to identify the most prevailing means of digital devices and its impact as digital pollution on family and social interactions. Despite the obvious benefits of digital devices, in recent years researchers have taken more concern about its potential negative effect on human attitude and behavior, which in turn affects our society. A total of 613 usable responses were collected from Bangalore, India of excessive users of digital devices, such as a smartphone, computer/laptop, and television. All statistical analyses were performed using SPSS 23.0, AMOS 23.0, and SmartPLS 3.0. The results indicated that as the use of smartphone and computer/laptop increases, levels of digital pollution also increase, which in turn significantly triggers unfavorable impact on family and social interactions. The study indicated that digital pollution appears as an important predictor, which significantly affects social interaction unfavorably. The present study explored the various critical dimensions within this domain and delineated gaps in our knowledge of digital pollution. It was found that smartphones are more responsible for digital pollution among all the identified digital devices, followed by computer/laptop.

Protective preparation: a process central to family caregivers of persons with mild cognitive impairment

2017 ◽  
Vol 30 (3) ◽  
pp. 375-384 ◽  
Author(s):  
Ching-Lin Wang ◽  
Li-Min Kuo ◽  
Yi-Chen Chiu ◽  
Hsiu-Li Huang ◽  
Huei-Ling Huang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Family Caregivers ◽  
Caregiver Burden ◽  
Family Caregiving ◽  
Healthcare Providers ◽  
Theory Approach ◽  
Face To Face ◽  
The Family ◽  
The Impact

ABSTRACTBackground:To develop a theoretical model explaining the longitudinal changes in the caregiving process for family caregivers of persons with mild cognitive impairment (MCI) in Taiwan.Methods:A longitudinal, grounded theory approach using in-depth face-to-face interviews and an open-ended interview guide. We conducted 42 interviews over a two-year period; each participant was interviewed at least once every six months. All participants were interviewed in their home. The participants total of 13 family caregivers of persons with MCI.Results:One core theme emerged: “protective preparation.” This reflected the family caregiving process of preparation for a further decline in cognitive function, and protection from the impact of low self-esteem, accidents, and symptoms of comorbidities for the family member with MCI. Protective preparation contained three components: ambivalent normalization, vigilant preparation, and protective management.Conclusions:Interventions to help family caregivers manage the changes in persons with MCI can reduce caregiver burden. Our findings could provide a knowledge base for use by healthcare providers to develop and implement strategies to reduce caregiver burden for family caregivers of persons with MCI.

Reformulation of the Family Life-Cycle Concept: Implications for Residential Mobility

1980 ◽  
Vol 12 (10) ◽  
pp. 1103-1118 ◽  
Author(s):  
Clare M Stapleton
Keyword(s):  
Life Cycle ◽  
Residential Mobility ◽  
Family Life ◽  
Life Cycle Model ◽  
Cycle Model ◽  
Social Science Theory ◽  
Science Theory ◽  
The Family ◽  
Comprehensive Framework ◽  
And Behavior

The conventional concept of linear progression through a traditional life cycle underlies much of social science theory. The utility of retaining the traditional life-cycle framework has declined rapidly as patterns of family and nonfamily structure and behavior have become more diversified. A more comprehensive framework which encompasses these new household types is suggested. The utility of this expanded life-cycle model is explored, with particular reference to single-headed family households and primary households.

Dr. Silver Replies

PEDIATRICS ◽  
1976 ◽  
Vol 58 (2) ◽  
pp. 299-299
Author(s):  
Larry B. Silver
Keyword(s):  
Family Physician ◽  
Learning Disorders ◽  
The Family

It is difficult to reply to Dr. Browder's comments for he suggests that I said certain things in my paper that I did not say and he suggests that I should have said other things which I did state in the paper. I do not feel that the field of learning disorders is outside the expertise of the physician. I refer to the physician as key to the coordinated efforts to help these children. My purpose in reviewing the literature was to assist the family physician.

Neurotoxicity of Hexachlorophene in the Human: I. A Clinicopathologic Study of 248 Children

PEDIATRICS ◽  
1974 ◽  
Vol 54 (6) ◽  
pp. 689-695
Author(s):  
Robert M. Shuman ◽  
Richard W. Leech ◽  
Ellsworth C. Alvord
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Newborn Infants ◽  
Whole Body ◽  
Human Beings ◽  
Term Neonates ◽  
Experimental Animals ◽  
Clinicopathologic Study ◽  
Neurotoxic Effects ◽  
Sick Children

To assess the susceptibility of human beings to the neurotoxic effects of hexachlorophene demonstrated in experimental animals, a blind clinicopathologic analysis was made of 248 children coming to autopsy over a 7.5-year period in the two Seattle institutions to which practically all premature or sick children are referred. Repeated whole-body bathing of premature newborn infants in 3% hexachlorophene-bearing soap (undiluted pHisoHex) is associated with a vacuolar encephalopathy of the brainstem reticular formation. The prevalence of the vacuolar encephalopathy appears to be related to the number of exposures to hexachlorophene, to the concentration of hexachiorophene, to the birth weight (gestational age), to the length of survival and to the thoroughness of rinsing. From these observations we conclude that hexachlorophene should not be used on neonates under 1,400 gm birth weight and should be used only sparingly in full-term neonates with thorough rinsing.

scholarly journals How Do We Love? Romantic Love Style in Men Is Related to Lower Testosterone Levels

2017 ◽  
pp. 695-703 ◽  
Author(s):  
J. BABKOVÁ DURDIAKOVÁ ◽  
P. CELEC ◽  
I. KOBOROVÁ ◽  
T. SEDLÁČKOVÁ ◽  
G. MINÁRIK ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Romantic Love ◽  
Social Background ◽  
Plasma Testosterone ◽  
Love Styles ◽  
Testosterone Levels ◽  
The Family ◽  
Low Testosterone ◽  
And Behavior ◽  
Attitudes And Behavior

Testosterone has been widely investigated in associations with many aspects of social interactions, emotions and behavior. No research has been conducted on its contribution to the variability of love styles in human. The aim of this paper was to uncover the possible relationship between not only the actual plasma testosterone levels, but also the prenatal testosterone level (expressed as 2D:4D ratio) and the sensitivity of androgen receptor and love typology in young healthy men. There are six love styles which are primary including Eros (passionate romantic love), Ludus (playful) and Storge (friendly) and secondary love consisting of Mania (obsessive), Pragma (practical realistic) and Agape (altruistic). Our results pointed out that low testosterone concentrations are associated with higher score for Eros, Ludus, Pragma, Mania love style. No significant association was proved for other tested parameters of androgenicity (2D:4D, sensitivity of androgen receptor) and love style after correction was applied. Different attitudes and behavior in relationships do have a biological foundation related to endogenous testosterone levels in plasma. Future studies should address questions about the family and social background of participants to differentiate here between moral rules or/and social-conventional rules.

scholarly journals PERAN ORANG TUA DALAM MEMBENTUK KARAKTER ANAK DI ERA GLOBALISASI DI DESA MASIGIT KELURAHAN CITANGKIL KOTA CILEGON

2020 ◽  
Vol 3 (2) ◽  
pp. 103-111
Author(s):  
Fitria Nuraini ◽  
Toni Anwar Mahmud
Keyword(s):  
Qualitative Research ◽  
Character Education ◽  
Family Environment ◽  
Negative Influence ◽  
Community Environment ◽  
The Family ◽  
Role Of Parents ◽  
And Behavior ◽  
Attitudes And Behavior

The title of the research is The Role of Parents in Shaping the Character of Children in the Globalization Era in Masigit Village, Citangkil Village, Cilegon City. In the current era of globalization, there are many influences, both positive and negative. This negative influence must be avoided because it can affect a person's habits, attitudes, and behavior. Character education is one of the important things that must be applied in the family environment. Parents must reflect good attitudes and habits in interacting in the family environment and in the community environment. This is important for fostering good attitudes and habits in children. The formulation of the problem in this study is how the role of parents in improving children's character in the era of globalization, Masigit Village, Citangkil Village, Cilegon City. What factors can influence the formation of children's character in the era of globalization, Masigit Village, Citangkil Village, Cilegon City. What efforts are made by parents in shaping children's character in the era of globalization in Masigit Village, Citangkil Village, Cilegon City. This study aims to determine the role of parents in shaping children's character in the era of globalization in Masigit Village, Citangkil Village, Cilegon City. The subjects of this study were 6 parents and 6 children in Masigit Village, Citangkil Village, Cilegon City. This research uses descriptive qualitative research methods. Data analysis in qualitative research is by doing data reduction, data presentation, and data verification. The results of this study indicate that the role of parents in Masigit Village, Citangkil Village, Cilegon City has been good in shaping children's character in the era of globalization.

scholarly journals URGENCY OF ISLAMIC EDUCATION IN CONSTRUCTING NOBLE BEHAVIOR: FAMILY STRUCTURE AS THE BASIS AND FOUNDATION OF MICRO-SCALE COMMUNITY REFORM COMMENCEMENT

2017 ◽  
Vol 5 (1) ◽  
pp. 197-224
Author(s):  
Habrun Habrun
Keyword(s):  
Family Structure ◽  
Family Environment ◽  
Islamic Education ◽  
Micro Scale ◽  
The Family ◽  
Community Reform ◽  
And Behavior ◽  
The Ideal

Islamic education in the family means education provided by members of the family, especially parents, to their children in the family environment to form the child's personality in order to be a muslim in which the attitude and behavior is in accordance with the teachings of Islam. The motivation of parent’s devotion in educating their children is solely for the sake of natural love, so, in this atmosphere of love, the process of education takes place well since the child is dependent to the family. Urgency of Islamic education in the family in building children’s noble character is the realization of the ideal human; intelligent and fear Allah SWT. إن التربية الإسلامية في الأسرة هي التربية التي يقوم بها أعضاء الأسرة خاصة الوالدين لأولادهما في وسط الأسرة لبناء السلوك حتى يكون الولد مسلما يتخلق بأخلاق تتفق مع تعاليم الإسلام. وحافز الأسرة في تربية الأولاد مؤسسة على الحب الفطري، فمن ظلال هذا الحب الفطري تجري عملية التربية بصورة جيدة في خلال سن الولد الذي يكون تحت مسؤولية الأسرة . وتكمن أهمية التربية الإسلامية في الأسرة لبناء الأخلاق الكريمة في تحقيق الشخصية المثالية، وهي الإنسان الذي يتقي الله سبحانه وتعالى وذكي. مفتاح الكلمات: التربية الإسلامية، الأسرة، الأخلاق الكريمة. Pendidikan Islam dalam keluarga yaitu pendidikan yang diberikan anggota kelurga terutama orang tua kepada anaknya dalam lingkungan keluarga itu sendiri untuk membentuk kepribadian anak menjadi muslim dengan adanya perubahan sikap dan tingkah laku yang sesuai dengan ajaran Islam. Motivasi pengabdian keluarga (ayah-ibu) dalam mendidik anak-anaknya semata-mata demi cinta kasih yang kodrati, sehingga dalam suasana cinta kasih dan kemesraan inilah proses pendidikan ini berlangsung dengan baik seumur anak dalam tanggungan utama keluarga. Urgensi Pendidikan Islam di lingkungan keluarga dalam pembinaan akhlak mulia anak adalah terwujudnya manusia yang ideal, yaitu anak yang bertakwa kepada Allah SWT. dan cerdas.

scholarly journals The Dynamic Modulation of GABAA Receptor Trafficking and Its Role in Regulating the Plasticity of Inhibitory Synapses

2011 ◽  
Vol 91 (3) ◽  
pp. 1009-1022 ◽  
Author(s):  
Mansi Vithlani ◽  
Miho Terunuma ◽  
Stephen J. Moss
Keyword(s):  
Neuronal Excitability ◽  
Tonic Inhibition ◽  
Inhibitory Synapses ◽  
General Anesthetics ◽  
Selective Stabilization ◽  
Neuronal Plasma Membrane ◽  
Sites Of Action ◽  
And Behavior ◽  
The Impact ◽  
The Brain

Inhibition in the adult mammalian central nervous system (CNS) is mediated by γ-aminobutyric acid (GABA). The fast inhibitory actions of GABA are mediated by GABA type A receptors (GABAARs); they mediate both phasic and tonic inhibition in the brain and are the principle sites of action for anticonvulsant, anxiolytic, and sedative-hypnotic agents that include benzodiazepines, barbiturates, neurosteroids, and some general anesthetics. GABAARs are heteropentameric ligand-gated ion channels that are found concentrated at inhibitory postsynaptic sites where they mediate phasic inhibition and at extrasynaptic sites where they mediate tonic inhibition. The efficacy of inhibition and thus neuronal excitability is critically dependent on the accumulation of specific GABAAR subtypes at inhibitory synapses. Here we evaluate how neurons control the number of GABAARs on the neuronal plasma membrane together with their selective stabilization at synaptic sites. We then go on to examine the impact that these processes have on the strength of synaptic inhibition and behavior.

Sign in / Sign up

Export Citation Format

Share Document