Assessment of Nucleotide Excision Repair XPD Polymorphisms in the Peripheral Blood of Gemcitabine/Cisplatin–Treated Advanced Non–Small-Cell Lung Cancer Patients

2003 ◽  
Vol 4 (4) ◽  
pp. 237-241 ◽  
Author(s):  
Carlos Camps ◽  
Carmen Sarries ◽  
Bárbara Roig ◽  
José Javier Sánchez ◽  
Cristina Queralt ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Nucleotide Excision Repair ◽  
Peripheral Blood ◽  
Excision Repair ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Nucleotide Excision

Nucleotide excision repair (NER) gene haplotypes and advanced non-small cell lung cancer (NSCLC) prognosis

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 3040-3040
Author(s):  
S. Gurubhagavatula ◽  
W. Zhou ◽  
S. Park ◽  
D. S. Neuberg ◽  
T. J. Lynch ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Nucleotide Excision Repair ◽  
Cell Lung Cancer ◽  
Excision Repair ◽  
Small Cell ◽  
Small Cell Lung ◽  
Nucleotide Excision

scholarly journals Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy

2021 ◽  
Vol 20 ◽  
pp. 153303382110399
Author(s):  
Hui Li ◽  
Hong Yu ◽  
Shaowei Lan ◽  
Dandan Zhao ◽  
Yan Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Peripheral Blood ◽  
Clinical Characteristics ◽  
Lymphocyte Subsets ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients

Purpose: The role of different circulating lymphocyte subsets, as well as their correlation with clinical characteristics of small cell lung cancer patients have not yet been fully understood. This study aims to evaluate the influence of the fluctuating absolute numbers of lymphocyte subpopulations in peripheral blood of patients with small cell lung cancer. Methods: The absolute counts and percentages of lymphocyte subsets in peripheral blood of 329 patients with small cell lung cancer were retrospectively analyzed. The numbers of CD3+, CD3+CD4+, and CD3+CD8+ T lymphocytes, CD3−CD19+ B lymphocytes, and CD3−CD16+CD56+ NK cells were evaluated by flow cytometry. Their relationship with the patients’ clinical characteristics were statistically evaluated. Results: The CD4/CD8 values derived from the absolute number and percentage of CD3+CD4+ cells divided by CD3+CD8+ cells were identical (1.86  ±  0.99). There was no association between any of the lymphocyte subsets levels and age/sex of the 329 patients with small cell lung cancer. The patients with advanced stage had a reduction in CD3+ and CD3+CD4+ T cell counts and a decreased CD4/CD8 ratio. The levels of CD3+CD4+ T cells, CD3−CD19+ B cells, CD3−CD16+CD56+ NK cells, and CD4/CD8 ratio were associated with advanced tumor-node-metastasis stage. Patients who had undergone radiotherapy were characterized by lymphopenia with lower numbers of CD3+, CD3+CD4+, CD3+CD8+ T lymphocyte, B lymphocyte, NK cell, and CD4/CD8 ratio. The evaluation of individual CD4/CD8 ratio should be combined with other clinical parameters. Conclusions: Patients with small cell lung cancer have altered lymphocyte homeostasis. Lymphopenia was a long-lasting feature of the enrolled patients who were treated with radiotherapy. The available lymphocyte subsets levels might be used to manage the clinical treatment scheme.

Sign in / Sign up

Export Citation Format

Share Document