Edge Fillet Radius Effect on Acoustic Energy in an Ultrasonic Microcontainer for Preparing Nanoemulsion

2019 ◽  
Vol 105 (6) ◽  
pp. 1243-1250
Author(s):  
S. M. M. Modarres-Gheisari ◽  
M. Mohammadpour ◽  
R. Gavagsaz-Ghoachani ◽  
P. Safarpour ◽  
M. Zandi

Nanoemulsion preparation and improvement play a pivotal role in the area of pharmaceuticals, food, mechanical, and chemical engineering. The ultrasonic technique is one of the most commonly used methods in preparing nanoemulsion, related to mechanical and electrical engineering. The present study aimed to evaluate the effect of edge fillet radius in four different layouts of a cubic ultrasonic microcontainer at different frequencies through 36 simulations by using COMSOL Multiphysics software. To this aim, the simulations were performed in three edge fillet radius values of zero, 2.5 and 5 mm, and at the excitation frequencies of 20, 200 and 300 kHz. In this regard, experimental tests were carried out in two modes of: a) regular ultrasonic bath (RUB) and b) filleted-edges ultrasonic bath (FEUB). Based on the simulation and experimental results, the removal of sharp edges has a positive influence on propagating waves, leading to an increase in the acoustic energy density at different frequencies and the effect was more significant at lower frequencies and layouts with more PZTs.

2017 ◽  
Vol 34 (4) ◽  
pp. 431-441 ◽  
Author(s):  
A. Samet ◽  
M. A. Ben Souf ◽  
O. Bareille ◽  
M. N. Ichchou ◽  
T. Fakhfakh ◽  
...  

AbstractAn inverse energy method for the identification of the structural force in high frequency ranges from radiated noise measurements is presented in this paper. The radiation of acoustic energy of the structure coupled to an acoustic cavity is treated using an energetic method called the simplified energy method. The main novelty of this paper consists in using the same energy method to solve inverse structural problem. It consists of localization and quantification of the vibration source through the knowledge of acoustic energy density. Numerical test cases with different measurement points are used for validation purpose. The numerical results show that the proposed method has an excellent performance in detecting the structural force with a few acoustical measurements.


Author(s):  
Aimin Wang ◽  
Nickolas Vlahopoulos ◽  
Jason Zhu ◽  
Mike Qian

An Energy Boundary Element Analysis (EBEA) formulation is presented for calculating sound radiation from a source with arbitrary shape at high frequency. The basic integral equation for the EBEA is derived including a half-space boundary condition. The time and frequency averaged acoustic energy density and acoustic intensity constitutes the primary variables of the new formulation, and the corresponding Green’s functions are derived. The governing equations for the EBEA are established and the numerical formulae for the coefficients of the system matrix, the acoustic energy density, and the acoustic intensity are derived using a Gaussian quadrature. The EBEA formulation and the corresponding numerical implementation are validated by comparing EBEA results to test data for the acoustic field around a vehicle that originates from an airborne noise source. Good correlation is demonstrated between numerical predictions and test data.


2004 ◽  
Vol 115 (5) ◽  
pp. 2612-2612
Author(s):  
Xi Chen ◽  
Scott D. Sommerfeldt ◽  
Timothy W. Leishman

1976 ◽  
Vol 60 (S1) ◽  
pp. S59-S59
Author(s):  
Bruce L. Morton ◽  
Elmer L. Hixson

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3043
Author(s):  
Qinying Yan ◽  
Jiaqi Weng ◽  
Shulin Shen ◽  
Yan Wang ◽  
Min Fang ◽  
...  

In this study, a micro-molding technology was used to prepare the microneedles (MNs), while a texture analyzer was used to measure its Young’s modulus, Poisson’s ratio and compression breaking force, to evaluate whether the MNs can penetrate the skin. The effects of different materials were characterized by their ability to withstand stresses using the Structural Mechanics Module of COMSOL Multiphysics. Carboxymethylcellulose (CMC) was chosen as the needle formulation material with varying quantities of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and hyaluronic acid (HA) to adjust the viscosity, brittleness, hardness and solubility of the material. The results of both the experimental tests and the predictions indicated that the hardest tip material had a solids content of 15% (w/w ) with a 1:2 (w/w) CMC: HA ratio. Furthermore, it was shown that a solid content of 10% (w/w) with a 1:5 (w/w) CMC: PVA ratio is suitable for making patches. The correlation between the mechanical properties and the different materials was found using the simulation analysis as well as the force required for different dissolving microneedles (DMNs) to penetrate the skin, which significantly promoted the research progress of microneedle transdermal drug delivery.


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