scholarly journals A prospective study of sodium valproate monotherapy in untreated epileptic patients: Serum concentrations and clinical effects.

1985 ◽  
Vol 3 (1) ◽  
pp. 1-10
Author(s):  
Yo Masubuchi
1992 ◽  
Vol 11 (2) ◽  
pp. 129-134 ◽  
Author(s):  
J.H. Perriëns ◽  
S. Benimadho ◽  
I. Lie Kiauw ◽  
J. Wisse ◽  
H. Chee

Between March 1986 and March 1988, 47 consecutive patients, whose paraquat intoxication was confirmed by urine testing, were enrolled in a prospective study on the treatment of paraquat poisoning. Fourteen received a standard treatment regimen consisting of fluid replacement and oral absorbents, and 33 received high-dose cyclophosphamide and dexamethasone, in addition to standard therapy. The case fatality rate in both treatment groups (63 and 61%) was similar. In addition, all 26 patients whose paraquat serum concentrations were measured and who had a probability of survival of less than 65% according the survival curve of Hart et al. died, regardless of therapy. These included four in the cyclophosphamide/dexamethasone group and two in the standard treatment group who had prior survival probabilities between 50 and 65%. This indicated that the cut-off curve relating mortality and paraquat serum concentrations was similar in both treatment groups. High-dose cyclophosphamide/dexamethasone treatment is unlikely to improve the prognosis of paraquat poisoning.


Brain ◽  
2011 ◽  
Vol 134 (10) ◽  
pp. 2887-2897 ◽  
Author(s):  
V. Brodbeck ◽  
L. Spinelli ◽  
A. M. Lascano ◽  
M. Wissmeier ◽  
M.-I. Vargas ◽  
...  

Epilepsia ◽  
2007 ◽  
Vol 48 (7) ◽  
pp. 1371-1377 ◽  
Author(s):  
Sudesh Prabhakar ◽  
Preeti Sahota ◽  
Parampreet Singh Kharbanda ◽  
Ravinder Siali ◽  
Vanita Jain ◽  
...  

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Birgit Bjerre Høyer ◽  
Cecilia Høst Ramlau-Hansen ◽  
Carsten Obel ◽  
Henning Sloth Pedersen ◽  
Agnieszka Hernik ◽  
...  

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