Concentrations of Carbamazepine and Carbamazepine-10,11-Epoxide in Serum, Brain Tumors and Paratumorous Cortex: A Prospective Study of 37 Neurosurgically Treated Epileptic Patients

1994 ◽  
Vol 34 (4) ◽  
pp. 213-220 ◽  
Author(s):  
R. Schnabel ◽  
B. Rambeck ◽  
T.W. May ◽  
U. Jürgens ◽  
R. Lahl
Keyword(s):  
Brain Tumors ◽  
Prospective Study ◽  
Epileptic Patients ◽  
A Prospective Study

scholarly journals Electroencephalographic source imaging: a prospective study of 152 operated epileptic patients

Brain ◽  
2011 ◽  
Vol 134 (10) ◽  
pp. 2887-2897 ◽  
Author(s):  
V. Brodbeck ◽  
L. Spinelli ◽  
A. M. Lascano ◽  
M. Wissmeier ◽  
M.-I. Vargas ◽  
...  
Keyword(s):  
Prospective Study ◽  
Source Imaging ◽  
Epileptic Patients ◽  
A Prospective Study

A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results

1989 ◽  
Vol 70 (5) ◽  
pp. 707-713 ◽  
Author(s):  
Roger J. Packer ◽  
Leslie N. Sutton ◽  
Thomas E. Atkins ◽  
Jerilynn Radcliffe ◽  
Greta R. Bunin ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Prospective Study ◽  
Intelligence Quotient ◽  
Neurocognitive Deficits ◽  
Verbal Iq ◽  
Malignant Brain Tumors ◽  
Visual Spatial ◽  
Wide Range ◽  
A Prospective Study ◽  
Over Time

✓ As survival rates have risen for children with malignant primary brain tumors, so has the concern that many survivors have significant permanent cognitive deficits. Cranial irradiation (CRT) has been implicated as the major cause for cognitive dysfunction. To clarify the etiology, incidence, and severity of intellectual compromise in children with brain tumors after CRT, a prospective study was undertaken comparing the neuropsychological outcome in 18 consecutive children with malignant brain tumors treated with CRT to outcome in 14 children harboring brain tumors in similar sites in the nervous system who had not received CRT. Children with cortical or subcortical brain tumors were not eligible for study. Neuropsychological testing was performed after surgery prior to radiotherapy, after radiotherapy, and at 1- and 2-year intervals thereafter. Children who had received CRT had a mean full-scale intelligence quotient (FSIQ) of 105 at diagnosis which fell to 91 by Year 2. Similar declines were noted in their performance intelligence quotient (IQ) and verbal IQ. After CRT, patients demonstrated a statistically significant decline from baseline in FSIQ (p < 0.02) and verbal IQ (p < 0.04). Children who had not received CRT did not demonstrate a fall in any cognitive parameter over time. The decline between baseline testing and testing performed at Year 2 in patients who had CRT was inversely correlated with age (p < 0.02), as younger children demonstrated the greatest loss of intelligence. Children less than 7 years of age at diagnosis had a mean decline in FSIQ of 25 points 2 years posttreatment. No other clinical parameter correlated with the overall IQ or decline in IQ. After CRT, children demonstrated a wide range of dysfunction including deficits in fine motor, visual-motor, and visual-spatial skills and memory difficulties. After CRT, children with brain tumors also demonstrated a fall in a wide range of achievement scores and an increased need, over time, for special help in school. The 2-year results of this study suggest that children with brain tumors treated with CRT are cognitively impaired and that these deficits worsen over time. The younger the child is at the time of treatment, the greater is the likelihood and severity of damage. These children, although not retarded, have a multitude of neurocognitive deficits which detrimentally affects school performance. New treatment strategies are needed for children with malignant brain tumors.

Temozolomide in rare brain tumors of the adult: a prospective study

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 1574-1574 ◽  
Author(s):  
R. Soffietti ◽  
A. Costanza ◽  
E. Laguzzi ◽  
E. Trevisan ◽  
R. Rudà
Keyword(s):  
Brain Tumors ◽  
Prospective Study ◽  
A Prospective Study
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