A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep

10.3791/62694 ◽  
2021 ◽  
Author(s):  
Rei Ukita ◽  
John W. Stokes ◽  
W. Kelly Wu ◽  
Jennifer Talackine ◽  
Nancy Cardwell ◽  
...  
Keyword(s):  
Animal Model ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Main Pulmonary Artery ◽  
Left Pulmonary Artery ◽  
Right Ventricular Failure ◽  
Large Animal Model ◽  
Large Animal ◽  
Ventricular Failure ◽  
Artery Ligation

Validation of Magnetic Resonance Phase-Contrast Flow Measurements in the Main Pulmonary Artery and Aorta Using Perivascular Ultrasound in a Large Animal Model

2008 ◽  
Vol 43 (6) ◽  
pp. 421-426 ◽  
Author(s):  
Sebastian Ley ◽  
Roland Unterhinninghofen ◽  
Julia Ley-Zaporozhan ◽  
Jens-Peter Schenk ◽  
Hans-Ulrich Kauczor ◽  
...  
Keyword(s):  
Animal Model ◽  
Magnetic Resonance ◽  
Pulmonary Artery ◽  
Phase Contrast ◽  
Main Pulmonary Artery ◽  
Large Animal Model ◽  
Large Animal ◽  
Flow Measurements ◽  
Contrast Flow ◽  
Phase Contrast Flow

scholarly journals Description, Staging and Quantification of Pulmonary Artery Angiophagy in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Biomedicines ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 493
Author(s):  
Frédéric Perros ◽  
Maria-Rosa Ghigna ◽  
Fanny Loisel ◽  
Denis Chemla ◽  
Benoit Decante ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Animal Model ◽  
Endothelial Cells ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Large Animal Model ◽  
Large Animal ◽  
Thromboembolic Pulmonary Hypertension ◽  
Three Stages

Angiophagy has been described as a non-fibrinolytic mechanism of pulmonary artery (PA) patency restoration after distal (<50 µm in diameter) pulmonary embolism in mice. We hypothesized that angiophagy could achieve muscularized PA patency restoration after pulmonary embolism in piglets and humans. Angiophagy was defined by pathological assessment as the moving of an embolic specimen from the lumen to the interstitium according to three stages in a pig model of chronic thromboembolic pulmonary hypertension (CTEPH) 6 to 10 weeks after embolization with enbucrilate: the embolic specimen is (I) covered by endothelial cells, (II) covered by endothelial cells and smooth muscle cells, and (III) located in the adventitia. In animals, we observed the three stages of the pulmonary angiophagy of enbucrilate emboli in <300 µm PA. Stages II and III were observed in 300 to 1000 μm PA, and only Stage I was observed in larger-diameter PA (>1000 μm). In lung samples from patients with histories of pulmonary embolisms, we observed PA angiophagy stigma for embolic specimens derived from blood clots and from bone marrow emboli. This study provides an original pathological description and staging of PA angiophagy in a large animal model of CTEPH and in humans after pulmonary embolism.

scholarly journals Supra-systemic pulmonary hypertension after complicated percutaneous mitral balloon valvuloplasty: a case report and review of literature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jose R. Navas-Blanco ◽  
Justin Miranda ◽  
Victor Gonzalez ◽  
Asif Mohammed ◽  
Oscar D. Aljure
Keyword(s):  
Pulmonary Hypertension ◽  
Case Report ◽  
Pulmonary Artery ◽  
Right Ventricular ◽  
Tissue Perfusion ◽  
Venous Hypertension ◽  
Right Ventricular Failure ◽  
Balloon Valvuloplasty ◽  
Ventricular Failure ◽  
The Moment

Abstract Background The World Symposium of Pulmonary Hypertension in 2018, updated the definition of pulmonary hypertension (PH) as mean pulmonary artery pressures (PAP) > 20 mmHg. Pulmonary venous hypertension secondary to left-heart disease, constitutes the most common cause of PH, and the determination of a co-existent pre-capillary (primary) PH becomes paramount, particularly at the moment of evaluating and managing patients with heart failure. Pulmonary artery pressures above the systemic pressures define supra-systemic PH and generally leads to frank right ventricular failure and high mortality. Case presentation We present the perioperative management of a patient with rheumatic mitral valve disease, initially found to have severe PH due to pulmonary venous hypertension, who underwent percutaneous mitral balloon valvuloplasty complicated with mitral chordae rupture, severe mitral regurgitation and supra-systemic PH. Multiple medical therapies and an intra-aortic balloon pump were used as means of non-surgical management of this complication. Conclusions This case report illustrates the perioperative implications of combined pre- and post-capillary PH and supra-systemic PH, as this has not been widely discussed in previous literature. A thorough literature review of the clinical characteristics of PH, methods to determine co-existent pre- and post-capillary PH components, as well as concomitant right ventricular failure is presented. Severe PH has known detrimental effects on the hemodynamic status of patients, which can ultimately lead to a decrease in effective cardiac output and poor tissue perfusion.

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