scholarly journals A Large Animal Model of Right Ventricular Failure due to Chronic Thromboembolic Pulmonary Hypertension: A Focus on Function

2019 ◽  
Vol 5 ◽  
Author(s):  
Ashley Mulchrone ◽  
Heidi B. Kellihan ◽  
Omid Forouzan ◽  
Timothy A. Hacker ◽  
Melissa L. Bates ◽  
...  
Keyword(s):  
Animal Model ◽  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Right Ventricular Failure ◽  
Large Animal Model ◽  
Large Animal ◽  
Ventricular Failure ◽  
Thromboembolic Pulmonary Hypertension

scholarly journals Description, Staging and Quantification of Pulmonary Artery Angiophagy in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Biomedicines ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 493
Author(s):  
Frédéric Perros ◽  
Maria-Rosa Ghigna ◽  
Fanny Loisel ◽  
Denis Chemla ◽  
Benoit Decante ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Animal Model ◽  
Endothelial Cells ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Large Animal Model ◽  
Large Animal ◽  
Thromboembolic Pulmonary Hypertension ◽  
Three Stages

Angiophagy has been described as a non-fibrinolytic mechanism of pulmonary artery (PA) patency restoration after distal (<50 µm in diameter) pulmonary embolism in mice. We hypothesized that angiophagy could achieve muscularized PA patency restoration after pulmonary embolism in piglets and humans. Angiophagy was defined by pathological assessment as the moving of an embolic specimen from the lumen to the interstitium according to three stages in a pig model of chronic thromboembolic pulmonary hypertension (CTEPH) 6 to 10 weeks after embolization with enbucrilate: the embolic specimen is (I) covered by endothelial cells, (II) covered by endothelial cells and smooth muscle cells, and (III) located in the adventitia. In animals, we observed the three stages of the pulmonary angiophagy of enbucrilate emboli in <300 µm PA. Stages II and III were observed in 300 to 1000 μm PA, and only Stage I was observed in larger-diameter PA (>1000 μm). In lung samples from patients with histories of pulmonary embolisms, we observed PA angiophagy stigma for embolic specimens derived from blood clots and from bone marrow emboli. This study provides an original pathological description and staging of PA angiophagy in a large animal model of CTEPH and in humans after pulmonary embolism.

Effect of sildenafil on right ventricular performance in an experimental large-animal model of postcapillary pulmonary hypertension

2021 ◽  
Vol 228 ◽  
pp. 64-75
Author(s):  
Evelyn Santiago-Vacas ◽  
Inés García-Lunar ◽  
Núria Solanes ◽  
Ana Paula Dantas ◽  
María Ascaso ◽  
...  
Keyword(s):  
Animal Model ◽  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Large Animal Model ◽  
Large Animal ◽  
Ventricular Performance ◽  
Right Ventricular Performance
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