scholarly journals Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

10.3791/61749 ◽  
2021 ◽  
Author(s):  
Md Huzzatul Mursalin ◽  
Erin Livingston ◽  
Phillip S. Coburn ◽  
Frederick C. Miller ◽  
Roger Astley ◽  
...  
Keyword(s):  
Mouse Model ◽  
Intravitreal Injection ◽  
Bacterial Endophthalmitis ◽  
Infection Parameters

scholarly journals Experimental Bacterial Endophthalmitis and Quantitation of Infection Parameters in a Mouse Model

2021 ◽  
Vol 39 ◽  
pp. S79-S80
Author(s):  
Rudraprasad Dhanwini ◽  
Naik Poonam ◽  
Milind N. Naik ◽  
Dilip K. Mishra
Keyword(s):  
Mouse Model ◽  
Bacterial Endophthalmitis ◽  
Infection Parameters

scholarly journals Studying macrophage activation in immune-privileged lens through CSF-1 protein intravitreal injection in mouse model

2022 ◽  
Vol 3 (1) ◽  
pp. 101060
Author(s):  
Yuting Li ◽  
Francisca M. Acosta ◽  
Yumeng Quan ◽  
Zhen Li ◽  
Sumin Gu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Intravitreal Injection ◽  
Macrophage Activation

scholarly journals A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE Cells

2020 ◽  
Vol 9 (7) ◽  
pp. 9 ◽  
Author(s):  
Alison Heffer ◽  
Victor Wang ◽  
Jayanth Sridhar ◽  
Steven E. Feldon ◽  
Richard T. Libby ◽  
...  
Keyword(s):  
Mouse Model ◽  
Intravitreal Injection ◽  
Proliferative Vitreoretinopathy ◽  
Rpe Cells

scholarly journals Pathogenicity of Ocular Isolates ofAcinetobacter baumanniiin a Mouse Model of Bacterial Endophthalmitis

2014 ◽  
Vol 55 (4) ◽  
pp. 2392 ◽  
Author(s):  
Deepa Talreja ◽  
Keith S. Kaye ◽  
Fu-shin Yu ◽  
Satish K. Walia ◽  
Ashok Kumar
Keyword(s):  
Mouse Model ◽  
Bacterial Endophthalmitis

scholarly journals Intravitreal Injection of Liposomes Loaded with a Histone Deacetylase Inhibitor Promotes Retinal Ganglion Cell Survival in a Mouse Model of Optic Nerve Crush

2020 ◽  
Vol 21 (23) ◽  
pp. 9297
Author(s):  
Mi Sun Sung ◽  
Myeong Ju Moon ◽  
Reju George Thomas ◽  
So Young Kim ◽  
Jun Sung Lee ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Mouse Model ◽  
Ganglion Cell ◽  
Intravitreal Injection ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Deacetylase Inhibitor

Various neuroprotective agents have been studied for the treatment of retinal ganglion cell (RGC) diseases, but issues concerning the side effects of systemically administered drugs and the short retention time of intravitreally injected drugs limit their clinical applications. The current study aimed to evaluate the neuroprotective effects of intravitreally injected trichostatin A (TSA)-loaded liposomes in a mouse model of optic nerve crush (ONC) and determine whether TSA-loaded liposomes have therapeutic potential in RGC diseases. The histone deacetylase inhibitor, TSA, was incorporated into polyethylene glycolylated liposomes. C57BL/6J mice were treated with an intravitreal injection of TSA-loaded liposomes and liposomes loaded with a lipophilic fluorescent dye for tracking, immediately after ONC injury. The expression of macroglial and microglial cell markers (glial fibrillary acidic protein and ionized calcium binding adaptor molecule-1), RGC survival, and apoptosis were assessed. We found that the liposomes reached the inner retina. Their fluorescence was detected for up to 10 days after the intravitreal injection, with peak intensity at 3 days postinjection. Intravitreally administered TSA-loaded liposomes significantly decreased reactive gliosis and RGC apoptosis and increased RGC survival in a mouse model of ONC. Our results suggest that TSA-loaded liposomes may help in the treatment of various RGC diseases.

A Large Outbreak of Fulminant Bacterial Endophthalmitis after Intravitreal Injection of Counterfeit Bevacizumab

2016 ◽  
Vol 254 (9) ◽  
pp. 1851-1856 ◽  
Author(s):  
Morteza Entezari ◽  
Saeed Karimi ◽  
Hamid Ahmadieh ◽  
Amir Hossein Mahmoudi ◽  
Hamid Parhizgar ◽  
...  
Keyword(s):  
Intravitreal Injection ◽  
Bacterial Endophthalmitis ◽  
Large Outbreak
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