Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy

10.3791/61603 ◽  
2021 ◽  
Author(s):  
Feng Ge ◽  
Jianfeng Xue ◽  
Yan He
Keyword(s):  
Cell Membrane ◽  
Gold Nanorods ◽  
Single Nanoparticle ◽  
Darkfield Microscopy

Size Effect on SERS of Gold Nanorods Demonstrated via Single Nanoparticle Spectroscopy

2016 ◽  
Vol 120 (37) ◽  
pp. 20806-20813 ◽  
Author(s):  
Kai-Qiang Lin ◽  
Jun Yi ◽  
Shu Hu ◽  
Bi-Ju Liu ◽  
Jun-Yang Liu ◽  
...  
Keyword(s):  
Size Effect ◽  
Gold Nanorods ◽  
Single Nanoparticle

Polyelectrolyte stiffness on gold nanorods mediates cell membrane damage

Nanoscale ◽  
2020 ◽  
Vol 12 (26) ◽  
pp. 14021-14036
Author(s):  
Nurul ‘Ain Azman ◽  
Laurent Bekale ◽  
Thanh Xuan Nguyen ◽  
James Chen Yong Kah
Keyword(s):  
Cell Membrane ◽  
Lipid Bilayer ◽  
Gold Nanorods ◽  
Mechanical Stability ◽  
Membrane Damage ◽  
Hemolysis Assay ◽  
Cell Membrane Damage

CGMD showed that ligand mechanical stability which resulted in the exposure of the hydrophobic AuNR core, disrupted the lipid bilayer organization. The damage was confirmed using hemolysis assay whereby lipid bilayer disruption resulted in the release of hemoglobin.

scholarly journals Real-Time QCM-D Monitoring of Deposition of Gold Nanorods on a Supported Lipid Bilayer as a Model Cell Membrane

ACS Omega ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 6059-6067 ◽  
Author(s):  
Huxiang Guo ◽  
Qiguo Xing ◽  
Renliang Huang ◽  
Dong Woog Lee ◽  
Rongxin Su ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Real Time ◽  
Lipid Bilayer ◽  
Gold Nanorods ◽  
Supported Lipid Bilayer ◽  
Model Cell ◽  
Model Cell Membrane

Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity

Nanoscale ◽  
2013 ◽  
Vol 5 (18) ◽  
pp. 8384 ◽  
Author(s):  
Liming Wang ◽  
Xiumei Jiang ◽  
Yinglu Ji ◽  
Ru Bai ◽  
Yuliang Zhao ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Surface Chemistry ◽  
Gold Nanorods ◽  
Membrane Damage ◽  
Cell Membrane Damage

Cancer cell membrane-coated gold nanorods for photothermal therapy and radiotherapy on oral squamous cancer

2020 ◽  
Vol 8 (32) ◽  
pp. 7253-7263
Author(s):  
Qiang Sun ◽  
Jinggen Wu ◽  
Lulu Jin ◽  
Liangjie Hong ◽  
Fang Wang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Squamous Cancer

Cancer cell membrane-coated gold nanorods are prepared for combinational photothermal therapy and radiation therapy of oral squamous cancer.

Photothermia and Activated Drug Release of Natural Cell Membrane Coated Plasmonic Gold Nanorods and β-Lapachone

2019 ◽  
Vol 2 (2) ◽  
pp. 728-736 ◽  
Author(s):  
Valeria S. Marangoni ◽  
Juliana Cancino Bernardi ◽  
Ianny B. Reis ◽  
Wagner J. Fávaro ◽  
Valtencir Zucolotto
Keyword(s):  
Drug Release ◽  
Cell Membrane ◽  
Gold Nanorods ◽  
Natural Cell

Selection of stabilizing agents to provide effective penetration of gold nanoparticles into cells

2014 ◽  
Vol 3 (4) ◽  
Author(s):  
Vadim V. Elagin ◽  
Ekaterina A. Sergeeva ◽  
Marina L. Bugrova ◽  
Nadezhda I. Ignatova ◽  
Diana V. Yuzhakova ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cell Membrane ◽  
Gold Nanorods ◽  
Outer Side ◽  
Cell Nuclei ◽  
Ovarian Adenocarcinoma ◽  
Plasmon Resonance Peak ◽  
Stabilizing Agents ◽  
Molecular Weights ◽  
Effective Penetration

AbstractObjective:Gold nanorods are known to be promising agents for photothermal therapy. But the uptake of rod-shaped nanoparticles is lower than their spherical counterpart. It was therefore the objective of this study to select gold nanoparticles (GNPs)-stabilizing agents in order to provide effective penetration into cancer cells.Materials and methods:The work was carried out on human ovarian adenocarcinoma SKOV-3 cells. The gold nanorods used in this work had a plasmon resonance peak at 800 nm. The nanoparticles were stabilized by PluronicResults:By means of 2PLM and TEM, it could be shown that PF127 facilitates cellular uptake of GNPs very effectively. PF127-stabilized GNPs rapidly (by 1.5 h) penetrated the cell membrane and into the cytoplasm and cell nucleus. GNPs stabilized by chitosan were slowly internalized by the cells in smaller amount. GNPs stabilized by PEG with different molecular weights had difficulty to penetrate into the cells – GNPs were localized on the outer side of the cell membrane after short incubation, and single agglomerates were found in the cells after an extended incubation time.Conclusion:Nanoparticles stabilized with PF127 were the most effective nanoparticles to penetrate into the cells and were located in the cytoplasm and cell nuclei. Nanoparticles stabilized with chitosan were internalized into cells at a slower rate and in smaller amounts than those stabilized with PF127. Nanoparticles stabilized with PEG

Differences in the Aspect Ratio of Gold Nanorods that Induce Defects in Cell Membrane Models

Langmuir ◽  
2017 ◽  
Vol 33 (50) ◽  
pp. 14286-14294 ◽  
Author(s):  
Paula M. P. Lins ◽  
Valéria S. Marangoni ◽  
Thiers M. Uehara ◽  
Paulo B. Miranda ◽  
Valtencir Zucolotto ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Cell Membrane ◽  
Gold Nanorods ◽  
Membrane Models

Plasmon Dephasing in Gold Nanorods Studied Using Single-Nanoparticle Interferometric Nonlinear Optical Microscopy

2016 ◽  
Vol 120 (7) ◽  
pp. 4071-4079 ◽  
Author(s):  
Tian Zhao ◽  
Jeremy W. Jarrett ◽  
Jeffrey S. Johnson ◽  
Kyoungweon Park ◽  
Richard A. Vaia ◽  
...  
Keyword(s):  
Optical Microscopy ◽  
Gold Nanorods ◽  
Nonlinear Optical ◽  
Nonlinear Optical Microscopy ◽  
Single Nanoparticle
Sign in / Sign up

Export Citation Format

Share Document