Photothermia and Activated Drug Release of Natural Cell Membrane Coated Plasmonic Gold Nanorods and β-Lapachone

2019 ◽  
Vol 2 (2) ◽  
pp. 728-736 ◽  
Author(s):  
Valeria S. Marangoni ◽  
Juliana Cancino Bernardi ◽  
Ianny B. Reis ◽  
Wagner J. Fávaro ◽  
Valtencir Zucolotto
Keyword(s):  
Drug Release ◽  
Cell Membrane ◽  
Gold Nanorods ◽  
Natural Cell

NIR responsive AuNRs/pNIPAM/PEGDA inverse opal hydrogel microcarriers for controllable drug delivery

2021 ◽  
Author(s):  
Lingzi Liu ◽  
Xiaoyan Sun ◽  
Baofen Ye ◽  
Zhengyu Yan
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Delivery System ◽  
Gold Nanorods ◽  
Controlled Drug Release ◽  
Inverse Opal

Particle-based delivery system has merged as a powerful platform in controlled drug release. The present study developed a new inverse opal hydrogel microcarriers system composed of gold nanorods (AuNRs) for...

Polyelectrolyte stiffness on gold nanorods mediates cell membrane damage

Nanoscale ◽  
2020 ◽  
Vol 12 (26) ◽  
pp. 14021-14036
Author(s):  
Nurul ‘Ain Azman ◽  
Laurent Bekale ◽  
Thanh Xuan Nguyen ◽  
James Chen Yong Kah
Keyword(s):  
Cell Membrane ◽  
Lipid Bilayer ◽  
Gold Nanorods ◽  
Mechanical Stability ◽  
Membrane Damage ◽  
Hemolysis Assay ◽  
Cell Membrane Damage

CGMD showed that ligand mechanical stability which resulted in the exposure of the hydrophobic AuNR core, disrupted the lipid bilayer organization. The damage was confirmed using hemolysis assay whereby lipid bilayer disruption resulted in the release of hemoglobin.

scholarly journals Real-Time QCM-D Monitoring of Deposition of Gold Nanorods on a Supported Lipid Bilayer as a Model Cell Membrane

ACS Omega ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 6059-6067 ◽  
Author(s):  
Huxiang Guo ◽  
Qiguo Xing ◽  
Renliang Huang ◽  
Dong Woog Lee ◽  
Rongxin Su ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Real Time ◽  
Lipid Bilayer ◽  
Gold Nanorods ◽  
Supported Lipid Bilayer ◽  
Model Cell ◽  
Model Cell Membrane

Gold Nanorods with Phase-Changing Polymer Corona for Remotely Near-Infrared-Triggered Drug Release

2013 ◽  
Vol 9 (1) ◽  
pp. 275-288 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Bruno Grignard ◽  
Marie-Claire De Pauw-Gillet ◽  
Stéphane Mornet ◽  
...  
Keyword(s):  
Drug Release ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Triggered Drug Release

Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity

Nanoscale ◽  
2013 ◽  
Vol 5 (18) ◽  
pp. 8384 ◽  
Author(s):  
Liming Wang ◽  
Xiumei Jiang ◽  
Yinglu Ji ◽  
Ru Bai ◽  
Yuliang Zhao ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Surface Chemistry ◽  
Gold Nanorods ◽  
Membrane Damage ◽  
Cell Membrane Damage

scholarly journals Tumor Microenvironment Stimuli-Responsive Macrophage Cell Membrane-Decorated Multi-Functional Self-Assembled Gold-Quantum Dots Nanomaterials for Tumor Theranostic

2021 ◽  
Author(s):  
Fan Wang ◽  
Qinghua Yu ◽  
Jia Li ◽  
Junhao Jiang ◽  
Tao Deng ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Drug Resistance ◽  
Tumor Microenvironment ◽  
Drug Release ◽  
Cell Membrane ◽  
Multimodal Therapy ◽  
Chemotherapy Resistance ◽  
Drug Resistant ◽  
Stimuli Responsive ◽  
Macrophage Cell

Abstract Tumor microenvironment (TME) is intently related to tumor growth, progression and invasion, leading to drug resistance and insufficient therapeutic efficacy. However, remodelling TME and utilizing TME for exploring intelligent nanomaterials that can realize tumor theranostic is still challenging. Nowadays, the theranostic based on chemotherapy exposes some deficiencies, such as low targeting, weak permeability and premature clearance. Furthermore, it is challenging to cure drug-resistant tumors effectively. For the sake of solving these problems, a biomimetic decomposable nano-theranostic (MMV-Au-CDs-DOX) was well-established in this work. The Au-CDs are coated with macrophage-derived microvesicle to realize drug release accurately and enhance the biocompatibility of internal nanoparticles. Furthermore, MMV-Au-CDs-DOX would locate in the inflammation position of tumor, and disintegrate correspondingly into pieces with certain different functions stimulated by TME. Subsequently, the released anti-tumor nanodrugs were used for multimodal therapy, including chemotherapy and chemodynamic therapy. In addition, combined with the ability of Au-CDs to recognize GSH specifically, the off-on fluorescent probe was constructed to monitor the GSH of patients and provided information on chemotherapy resistance.

scholarly journals Stimuli-Responsive Nanofibers Containing Gold Nanorods for On-Demand Drug Delivery Platforms

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1319
Author(s):  
Baljinder Singh ◽  
Nutan Shukla ◽  
Junkee Kim ◽  
Kibeom Kim ◽  
Myoung-Hwan Park
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Resonance Effect ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
On Demand ◽  
Multiple Drugs

On-demand drug delivery systems using nanofibers have attracted significant attention owing to their controllable properties for drug release through external stimuli. Near-infrared (NIR)-responsive nanofibers provide a platform where the drug release profile can be achieved by the on-demand supply of drugs at a desired dose for cancer therapy. Nanomaterials such as gold nanorods (GNRs) exhibit absorbance in the NIR range, and in response to NIR irradiation, they generate heat as a result of a plasmon resonance effect. In this study, we designed poly (N-isopropylacrylamide) (PNIPAM) composite nanofibers containing GNRs. PNIPAM is a heat-reactive polymer that provides a swelling and deswelling property to the nanofibers. Electrospun nanofibers have a large surface-area-to-volume ratio, which is used to effectively deliver large quantities of drugs. In this platform, both hydrophilic and hydrophobic drugs can be introduced and manipulated. On-demand drug delivery systems were obtained through stimuli-responsive nanofibers containing GNRs and PNIPAM. Upon NIR irradiation, the heat generated by the GNRs ensures shrinking of the nanofibers owing to the thermal response of PNIPAM, thereby resulting in a controlled drug release. The versatility of the light-responsive nanofibers as a drug delivery platform was confirmed in cell studies, indicating the advantages of the swelling and deswelling property of the nanofibers and on–off drug release behavior with good biocompatibility. In addition, the system has potential for the combination of chemotherapy with multiple drugs to enhance the effectiveness of complex cancer treatments.

Photocatalytic Degradation of Cell Membrane Coatings for Controlled Drug Release

2016 ◽  
Vol 5 (12) ◽  
pp. 1420-1427 ◽  
Author(s):  
Lang Rao ◽  
Qian-Fang Meng ◽  
Qinqin Huang ◽  
Pei Liu ◽  
Lin-Lin Bu ◽  
...  
Keyword(s):  
Drug Release ◽  
Cell Membrane ◽  
Photocatalytic Degradation ◽  
Controlled Drug Release

pH-Sensitive Gold Nanorods with a Mesoporous Silica Shell for Drug Release and Photothermal Therapy

2015 ◽  
Vol 2015 (13) ◽  
pp. 2277-2284 ◽  
Author(s):  
Ting Zhang ◽  
Zeyang Ding ◽  
Huiming Lin ◽  
Liru Cui ◽  
Chunyu Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Silica Shell ◽  
Ph Sensitive
Sign in / Sign up

Export Citation Format

Share Document