Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

10.3791/60741 ◽  
2020 ◽  
Author(s):  
Nicolette Driscoll ◽  
Kathleen Maleski ◽  
Andrew G. Richardson ◽  
Brendan Murphy ◽  
Babak Anasori ◽  
...  
Keyword(s):  
Microelectrode Arrays ◽  
Neural Recording

scholarly journals Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation

2020 ◽  
Vol 101 ◽  
pp. 565-574 ◽  
Author(s):  
Rahul Atmaramani ◽  
Bitan Chakraborty ◽  
Rashed T. Rihani ◽  
Joshua Usoro ◽  
Audrey Hammack ◽  
...  
Keyword(s):  
Microelectrode Arrays ◽  
Ruthenium Oxide ◽  
Neural Recording

scholarly journals Wafer-Scale Fabrication and Assembly Method of Multichannel Microelectrode Arrays for ECoG Application

Electronics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 316
Author(s):  
Cong Wang ◽  
Yu-Chen Wei ◽  
Ho-Kun Sung ◽  
Alok Kumar ◽  
Zhong-Liang Zhou ◽  
...  
Keyword(s):  
Printed Circuit Boards ◽  
Electrochemical Impedance ◽  
Microelectrode Arrays ◽  
Absence Seizure ◽  
Curing Conditions ◽  
Wafer Scale ◽  
In Vivo Test ◽  
Assembly Method ◽  
Signal Recording

High density electrocorticography (ECoG)-based microelectrode arrays (MEAs) are fabricated to timely record the neural activities to provide the fundamental understanding in neuroscience and biomedical engineering. This paper aims to introduce a device-based concept and wafer-scale fabrication process for MEAs. Flexible and biocompatible polyimide is applied on MEAs to bear all possible stress and strain. Detailed fabrication key techniques, including surface treatment, polyimide stability measurement, evaporation process, and curing conditions, have been discussed thoroughly. Moreover, the fabricated polyimide-based MEAs are surface-mounted on well-packaged printed circuit boards (PCBs) via a slot-type connector without any additional wire bonding to make the signal recording process easier. An absence seizure was recorded during the in vivo test, which shows the availability of signal recording based on the presented MEAs. The proposed MEAs could be remained at the skull, while the connector and PCBs can be disassembled apart. Therefore, the testing sample will get less suffering. To verify the robustness of the fabricated MEAs, the impedance properties were characterized using electrochemical impedance spectroscopy. The measured results indicate an average impedance of 12.3 ± 0.675 kΩ at 1 kHz. In total, 10 groups of MEAs were sample tested, and over 90% of the total 60 channels per 1-MEAs operated efficiently.

scholarly journals Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 725
Author(s):  
Saeyeong Jeon ◽  
Youjin Lee ◽  
Daeho Ryu ◽  
Yoon Kyung Cho ◽  
Yena Lee ◽  
...  
Keyword(s):  
Light Emitting Diode ◽  
Neural Recording ◽  
Electrophysiological Recording ◽  
Light Emitting ◽  
Technological Advances ◽  
Neuroscience Research ◽  
Cell Type Specific ◽  
Novel Design

During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophysiological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording.

scholarly journals Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo

2017 ◽  
Vol 5 (13) ◽  
pp. 2445-2458 ◽  
Author(s):  
I. Mitch Taylor ◽  
Zhanhong Du ◽  
Emma T. Bigelow ◽  
James R. Eles ◽  
Anthony R. Horner ◽  
...  
Keyword(s):  
Electrochemical Detection ◽  
Direct Measurement ◽  
Neural Recording ◽  
Dna Aptamer ◽  
Silicon Based ◽  
The Brain ◽  
Recording Electrodes

First everin vivosensor for directly measuring cocaine concentration in the brainviaelectrochemical detection at DNA aptamer functionalized single shank, silicon-based neural recording probes.

In-vivo validation of a compact inductively-powered neural recording interface

2014 ◽  
Author(s):  
Mahsa Shoaran ◽  
Gurkan Yilmaz ◽  
Ramesh Periasamy ◽  
Stefanie Seiler ◽  
Stefano Di Santo ◽  
...  
Keyword(s):  
Neural Recording ◽  
In Vivo Validation

scholarly journals Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays

Biomaterials ◽  
2019 ◽  
Vol 205 ◽  
pp. 120-132 ◽  
Author(s):  
Isaac R. Cassar ◽  
Chunxiu Yu ◽  
Jaydeep Sambangi ◽  
Curtis D. Lee ◽  
John J. Whalen ◽  
...  
Keyword(s):  
Microelectrode Arrays

Maskless production of neural-recording graphene microelectrode arrays

2019 ◽  
Vol 37 (2) ◽  
pp. 022202
Author(s):  
Vanessa Pereira Gomes ◽  
Aline Maria Pascon ◽  
Roberto Ricardo Panepucci ◽  
Jacobus Willibrordus Swart
Keyword(s):  
Microelectrode Arrays ◽  
Neural Recording
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