scholarly journals In Vivo Validation of Custom-Designed Silicon-Based Microelectrode Arrays for Long-Term Neural Recording and Stimulation

2012 ◽  
Vol 59 (2) ◽  
pp. 346-354 ◽  
Author(s):  
M. Han ◽  
P. S. Manoonkitiwongsa ◽  
C. X. Wang ◽  
D. B. McCreery
Keyword(s):  
Microelectrode Arrays ◽  
Neural Recording ◽  
Silicon Based ◽  
In Vivo Validation

scholarly journals Long-term in-vivo recording performance of flexible penetrating microelectrode arrays

2021 ◽  
Vol 18 (6) ◽  
pp. 066018
Author(s):  
Jae-Won Jang ◽  
Yoo Na Kang ◽  
Hee Won Seo ◽  
Boil Kim ◽  
Han Kyoung Choe ◽  
...  
Keyword(s):  
Signal To Noise Ratio ◽  
Microelectrode Arrays ◽  
High Signal ◽  
Robotic Arms ◽  
Single Neuron Recording ◽  
Tissue Reactions ◽  
Physical Degradation ◽  
Silicon Based

Abstract Objective. Neural interfaces are an essential tool to enable the human body to directly communicate with machines such as computers or prosthetic robotic arms. Since invasive electrodes can be located closer to target neurons, they have advantages such as precision in stimulation and high signal-to-noise ratio (SNR) in recording, while they often exhibit unstable performance in long-term in-vivo implantation because of the tissue damage caused by the electrodes insertion. In the present study, we investigated the electrical functionality of flexible penetrating microelectrode arrays (FPMAs) up to 3 months in in-vivo conditions. Approach. The in-vivo experiment was performed by implanting FPMAs in five rats. The in-vivo impedance as well as the action potential (AP) amplitude and SNR were analyzed over weeks. Additionally, APs were tracked over time to investigate the possibility of single neuron recording. Main results. It was observed that the FPMAs exhibited dramatic increases in impedance for the first 4 weeks after implantation, accompanied by decreases in AP amplitude. However, the increase/decrease in AP amplitude was always accompanied by the increase/decrease in background noise, resulting in quite consistently maintained SNRs. After 4 weeks of implantation, we observed two distinctive issues regarding long-term implantation, each caused by chronic tissue responses or by the delamination of insulation layer. The results demonstrate that the FPMAs successfully recorded neuronal signals up to 12 weeks, with very stably maintained SNRs, reduced by only 16.1% on average compared to the first recordings, although biological tissue reactions or physical degradation of the FPMA were present. Significance. The fabricated FPMAs successfully recorded intracortical signals for 3 months. The SNR was maintained up to 3 months and the chronic function of FPMA was comparable with other silicon based implantable electrodes.

scholarly journals Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo

2017 ◽  
Vol 5 (13) ◽  
pp. 2445-2458 ◽  
Author(s):  
I. Mitch Taylor ◽  
Zhanhong Du ◽  
Emma T. Bigelow ◽  
James R. Eles ◽  
Anthony R. Horner ◽  
...  
Keyword(s):  
Electrochemical Detection ◽  
Direct Measurement ◽  
Neural Recording ◽  
Dna Aptamer ◽  
Silicon Based ◽  
The Brain ◽  
Recording Electrodes

First everin vivosensor for directly measuring cocaine concentration in the brainviaelectrochemical detection at DNA aptamer functionalized single shank, silicon-based neural recording probes.

In-vivo validation of a compact inductively-powered neural recording interface

2014 ◽  
Author(s):  
Mahsa Shoaran ◽  
Gurkan Yilmaz ◽  
Ramesh Periasamy ◽  
Stefanie Seiler ◽  
Stefano Di Santo ◽  
...  
Keyword(s):  
Neural Recording ◽  
In Vivo Validation

scholarly journals Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation

2020 ◽  
Vol 101 ◽  
pp. 565-574 ◽  
Author(s):  
Rahul Atmaramani ◽  
Bitan Chakraborty ◽  
Rashed T. Rihani ◽  
Joshua Usoro ◽  
Audrey Hammack ◽  
...  
Keyword(s):  
Microelectrode Arrays ◽  
Ruthenium Oxide ◽  
Neural Recording

scholarly journals Long-term in-vivo analysis of flexible penetrating microelectrode arrays

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S269
Author(s):  
Jaewon Jang ◽  
Yoona Kang ◽  
Heewon Seo ◽  
Sohee Kim
Keyword(s):  
Microelectrode Arrays ◽  
In Vivo Analysis

scholarly journals Low-Power, High Data Rate Transceiver System for Implantable Prostheses

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
A. R. Kahn ◽  
E. Y. Chow ◽  
O. Abdel-Latief ◽  
P. P. Irazoqui
Keyword(s):  
Ex Vivo ◽  
Neural Recording ◽  
Wireless Link ◽  
High Data ◽  
Multiple Electrodes ◽  
Data Rates ◽  
High Data Rates ◽  
Implanted Transmitter

Wireless telemetry is crucial for long-term implantable neural recording systems. RF-encoded neurological signals often require high data-rates to transmit information from multiple electrodes with a sufficient sampling frequency and resolution. In this work, we quantify the effects of interferers and tissue attenuation on a wireless link for optimal design of future systems. The wireless link consists of an external receiver capable of demodulating FSK/OOK transmission at speeds up to 8 Mbps, with <1e-5 bit-error rate (BER) without error correction, and a fully implanted transmitter consuming about 1.05 mW. The external receiver is tested with the transmitterin vivoto show demodulation efficacy of the transcutaneous link at high data-rates. Transmitter/Receiver link BER is quantified in typical and controlled RF environments for ex vivo andin vivoperformance.

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

10.3791/60741 ◽  
2020 ◽  
Author(s):  
Nicolette Driscoll ◽  
Kathleen Maleski ◽  
Andrew G. Richardson ◽  
Brendan Murphy ◽  
Babak Anasori ◽  
...  
Keyword(s):  
Microelectrode Arrays ◽  
Neural Recording
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