Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

10.3791/60102 ◽  
2019 ◽  
Author(s):  
Enas N. Yousef ◽  
Ramakrishna Sesham ◽  
Jacob W. McCabe ◽  
Rajpal Vangala ◽  
Laurence A. Angel
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Metal Binding ◽  
Metal Ion ◽  
Redox Activity ◽  
Ion Mobility Mass Spectrometry ◽  
Ion Recognition

Improving glycan isomeric separation via metal ion incorporation for drift tube ion mobility-mass spectrometry

Talanta ◽  
2020 ◽  
Vol 211 ◽  
pp. 120719 ◽  
Author(s):  
Chengyi Xie ◽  
Qidi Wu ◽  
Shulei Zhang ◽  
Chenlu Wang ◽  
Wenqing Gao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Metal Ion ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Ion Incorporation

Rapid Diagnosis of Parkinson’s Disease from Sebum using Paper Spray Ionisation Ion Mobility Mass Spectrometry

2020 ◽  
Author(s):  
Depanjan Sarkar ◽  
Drupad Trivedi ◽  
Eleanor Sinclair ◽  
Sze Hway Lim ◽  
Caitlin Walton-Doyle ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ion Mobility ◽  
Neurodegenerative Disorder ◽  
Treatment Options ◽  
Ion Mobility Mass Spectrometry ◽  
Paper Spray ◽  
Molecular Features ◽  
Validation Set

Parkinson’s disease (PD) is the second most common neurodegenerative disorder for which identification of robust biomarkers to complement clinical PD diagnosis would accelerate treatment options and help to stratify disease progression. Here we demonstrate the use of paper spray ionisation coupled with ion mobility mass spectrometry (PSI IM-MS) to determine diagnostic molecular features of PD in sebum. PSI IM-MS was performed directly from skin swabs, collected from 34 people with PD and 30 matched control subjects as a training set and a further 91 samples from 5 different collection sites as a validation set. PSI IM-MS elucidates ~ 4200 features from each individual and we report two classes of lipids (namely phosphatidylcholine and cardiolipin) that differ significantly in the sebum of people with PD. Putative metabolite annotations are obtained using tandem mass spectrometry experiments combined with accurate mass measurements. Sample preparation and PSI IM-MS analysis and diagnosis can be performed ~5 minutes per sample offering a new route to for rapid and inexpensive confirmatory diagnosis of this disease.

P‐97: Separation of Isomeric OLED Materials Using Ion Mobility‐Mass Spectrometry (IM‐MS)

2021 ◽  
Vol 52 (1) ◽  
pp. 1444-1447
Author(s):  
Hirotaka Shioji ◽  
Azusa Uematsu ◽  
Motoshi Onoda ◽  
Keiko Matsuda ◽  
Keisuke Sawada ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Ion Mobility Mass Spectrometry
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