scholarly journals A Neonatal Mouse Spinal Cord Compression Injury Model

10.3791/53498 ◽  
2016 ◽  
Author(s):  
Mark Züchner ◽  
Joel C. Glover ◽  
Jean-Luc Boulland
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Neonatal Mouse ◽  
Compression Injury ◽  
Mouse Spinal Cord ◽  
Injury Model

A No-Laminectomy Spinal Cord Compression Injury Model in Mice

2004 ◽  
Vol 21 (5) ◽  
pp. 595-603 ◽  
Author(s):  
Huaxin Sheng ◽  
Haichen Wang ◽  
Hercilia M. Homi ◽  
Ivan Spasojevic ◽  
Ines Batinic-Haberle ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Compression Injury ◽  
Injury Model

scholarly journals Improved rat spinal cord injury model using spinal cord compression by percutaneous method

2013 ◽  
Vol 14 (3) ◽  
pp. 329 ◽  
Author(s):  
Wook-Hun Chung ◽  
Jae-Hoon Lee ◽  
Dai-Jung Chung ◽  
Wo-Jong Yang ◽  
A-Jin Lee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Rat Spinal Cord ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats

Life Sciences ◽  
2019 ◽  
Vol 222 ◽  
pp. 148-157 ◽  
Author(s):  
Jian Li ◽  
Zhiqiang Jia ◽  
Wen Xu ◽  
Weidong Guo ◽  
Mingchao Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Glial Scar ◽  
Scar Formation ◽  
Compression Injury ◽  
Astrocyte Activation

A characterization of white matter pathology following spinal cord compression injury in the rat

Neuroscience ◽  
2014 ◽  
Vol 260 ◽  
pp. 227-239 ◽  
Author(s):  
R.E. Ward ◽  
W. Huang ◽  
M. Kostusiak ◽  
P.N. Pallier ◽  
A.T. Michael-Titus ◽  
...  
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Compression Injury ◽  
White Matter Pathology

Elevated gene expression in the red nucleus after spinal cord compression injury

Neuroreport ◽  
1992 ◽  
Vol 3 (7) ◽  
pp. 559-562 ◽  
Author(s):  
Elizabeth Theriault ◽  
Wolfram Tetzlaff ◽  
Charles H. Tator
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Red Nucleus ◽  
Cord Compression ◽  
Compression Injury

A remotely controlled model of spinal cord compression injury in mice: toward real-time analysis

2009 ◽  
Vol 11 (4) ◽  
pp. 461-470 ◽  
Author(s):  
Pascal Kouyoumdjian ◽  
Nicolas Lonjon ◽  
Monica Prieto ◽  
Henri Haton ◽  
Alain Privat ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Mr Imaging ◽  
Real Time ◽  
Spinal Cord Compression ◽  
Spinal Cord Injuries ◽  
Cord Compression ◽  
Genetically Engineered ◽  
In Vivo Studies ◽  
Compression Injury

Object To date, there has been no efficient therapeutic approach to spinal cord injuries (SCIs). This may be attributable, at least in part, to difficulties in forming predictive and accurate experimental animal models. The authors' previous studies have identified 2 relevant conditions of such a model. The first condition is the ability to compare data derived from rat models of SCI by developing mouse models of SCI that permit access to a large range of transgenic models. The second condition is that the exploration of the consequences of each mechanism of spinal trauma requires modeling the different etiologic aspects of the injury. Methods To fulfill these 2 conditions a new model of mouse spinal cord compression injury was devised using a thread-driven olive-shaped compressive device. The authors characterized early motor, sensory, and histological outcomes using 3 olive diameters and different compression durations. Results A gradual and reproducible functional severity that correlated with lesion extension was demonstrated in 76 mice. To further substantiate the characterization of this model, a noncompetitive N-methyl-d-aspartate antagonist was administered in 30 mice, which demonstrated the involvement of excitotoxicity in this model. Conclusions The study demonstrated that spinal olive-compression injury in the mouse is a reproducible, well-characterized, and predictable model for analyzing early events after SCI. The nonmagnetic and remotely controlled design of this model will allow completion of the lesion while the animal is in the MR imaging apparatus, thus permitting further real-time MR imaging studies that will provide insights into the characterization of early events in the spatial and temporal evolution of SCI. Moreover, this model lays the foundation for future in vivo studies of functional and histological outcomes following SCI in genetically engineered animals.

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