Spinal cord compression injury in the mouse: presentation of a model including assessment of motor dysfunction

2000 ◽  
Vol 100 (1) ◽  
pp. 13-22 ◽  
Author(s):  
M. Farooque
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Motor Dysfunction ◽  
Compression Injury

scholarly journals Cervical myelopathy due to neurovascular compression syndrome caused by persistent first intersegmental artery: a case report

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Takuro Endo ◽  
Taku Sugawara ◽  
Naoki Higashiyama
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cervical Myelopathy ◽  
Anatomical Variation ◽  
Cord Compression ◽  
Burning Sensation ◽  
Motor Dysfunction ◽  
Neurological Deficits ◽  
Left Shoulder ◽  
Neurovascular Compression

Abstract Background Persistent first intersegmental artery (PFIA) is a rare anatomical variation of vertebral arteries and is an asymptomatic finding in most cases. Here we report a rare case of cervical myelopathy caused by spinal cord compression by the PFIA. Case presentation The patient was a 52-year-old man who complained of numbness and burning sensation around the neck and left shoulder area, partial weakness in the left deltoid muscle, right side thermal hypoalgesia, and disturbance of deep sensation since the past 1 year, and the symptoms had gradually worsened. Magnetic resonance imaging (MRI) and computed tomography (CT) showed spinal cord compression by the left PFIA at the C1/C2 level. Because conservative treatment was ineffective, microvascular decompression (MVD) of the PFIA was performed. The left PFIA was laterally transposed using polytetrafluoroethylene (PTFE) bands and anchored to the dura mater using three PTFE bands. To achieve adequate transposition, the small blood vessels bridging the spinal cord and PFIA and the dorsal root nerve had to be sacrificed. Postoperative T2-weighted MRI showed a small hyperintense region in the lateral funiculus of the spinal cord, but no new neurological deficits were identified. In the early postoperative stage, the patient’s deep sensory impairment and motor dysfunction were improved. His numbness and burning sensation almost disappeared, but slight thermal hypoalgesia remained in the lower limb. Conclusion MVD is an effective treatment for spinal cord compression caused by the PFIA, but further studies are necessary to help address technical difficulties and avoid complications.

TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats

Life Sciences ◽  
2019 ◽  
Vol 222 ◽  
pp. 148-157 ◽  
Author(s):  
Jian Li ◽  
Zhiqiang Jia ◽  
Wen Xu ◽  
Weidong Guo ◽  
Mingchao Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Glial Scar ◽  
Scar Formation ◽  
Compression Injury ◽  
Astrocyte Activation

A characterization of white matter pathology following spinal cord compression injury in the rat

Neuroscience ◽  
2014 ◽  
Vol 260 ◽  
pp. 227-239 ◽  
Author(s):  
R.E. Ward ◽  
W. Huang ◽  
M. Kostusiak ◽  
P.N. Pallier ◽  
A.T. Michael-Titus ◽  
...  
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Compression Injury ◽  
White Matter Pathology

Elevated gene expression in the red nucleus after spinal cord compression injury

Neuroreport ◽  
1992 ◽  
Vol 3 (7) ◽  
pp. 559-562 ◽  
Author(s):  
Elizabeth Theriault ◽  
Wolfram Tetzlaff ◽  
Charles H. Tator
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Red Nucleus ◽  
Cord Compression ◽  
Compression Injury

A remotely controlled model of spinal cord compression injury in mice: toward real-time analysis

2009 ◽  
Vol 11 (4) ◽  
pp. 461-470 ◽  
Author(s):  
Pascal Kouyoumdjian ◽  
Nicolas Lonjon ◽  
Monica Prieto ◽  
Henri Haton ◽  
Alain Privat ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Mr Imaging ◽  
Real Time ◽  
Spinal Cord Compression ◽  
Spinal Cord Injuries ◽  
Cord Compression ◽  
Genetically Engineered ◽  
In Vivo Studies ◽  
Compression Injury

Object To date, there has been no efficient therapeutic approach to spinal cord injuries (SCIs). This may be attributable, at least in part, to difficulties in forming predictive and accurate experimental animal models. The authors' previous studies have identified 2 relevant conditions of such a model. The first condition is the ability to compare data derived from rat models of SCI by developing mouse models of SCI that permit access to a large range of transgenic models. The second condition is that the exploration of the consequences of each mechanism of spinal trauma requires modeling the different etiologic aspects of the injury. Methods To fulfill these 2 conditions a new model of mouse spinal cord compression injury was devised using a thread-driven olive-shaped compressive device. The authors characterized early motor, sensory, and histological outcomes using 3 olive diameters and different compression durations. Results A gradual and reproducible functional severity that correlated with lesion extension was demonstrated in 76 mice. To further substantiate the characterization of this model, a noncompetitive N-methyl-d-aspartate antagonist was administered in 30 mice, which demonstrated the involvement of excitotoxicity in this model. Conclusions The study demonstrated that spinal olive-compression injury in the mouse is a reproducible, well-characterized, and predictable model for analyzing early events after SCI. The nonmagnetic and remotely controlled design of this model will allow completion of the lesion while the animal is in the MR imaging apparatus, thus permitting further real-time MR imaging studies that will provide insights into the characterization of early events in the spatial and temporal evolution of SCI. Moreover, this model lays the foundation for future in vivo studies of functional and histological outcomes following SCI in genetically engineered animals.

Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid

2013 ◽  
Vol 239 ◽  
pp. 13-27 ◽  
Author(s):  
Siew-Na Lim ◽  
Wenlong Huang ◽  
Jodie C.E. Hall ◽  
Adina T. Michael-Titus ◽  
John V. Priestley
Keyword(s):  
Spinal Cord ◽  
Docosahexaenoic Acid ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Compression Injury ◽  
Improved Outcome
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