scholarly journals Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

10.3791/53457 ◽  
2016 ◽  
Author(s):  
Richard R. Uwiera ◽  
Rabban Mangat ◽  
Sandra Kelly ◽  
Trina C. Uwiera ◽  
Spencer D. Proctor
Keyword(s):  
Neonatal Pigs ◽  
Intestinal Lymph

scholarly journals Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigs

Amino Acids ◽  
2010 ◽  
Vol 40 (1) ◽  
pp. 157-165 ◽  
Author(s):  
Fiona A. Wilson ◽  
Agus Suryawan ◽  
Renán A. Orellana ◽  
María C. Gazzaneo ◽  
Hanh V. Nguyen ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Tissue Protein ◽  
Differential Effects ◽  
Neonatal Pigs ◽  
Tissue Protein Synthesis

scholarly journals Long‐term Intermittent Leucine Pulses during Continuous Feeding Impact the Plasma Metabolome of Neonatal Pigs

2016 ◽  
Vol 30 (S1) ◽  
Author(s):  
Agus Suryawan ◽  
Claire Boutry ◽  
Rodrigo Manjarín ◽  
Samer W. El‐Kadi ◽  
Julia Steinhoff‐Wagner ◽  
...  
Keyword(s):  
Neonatal Pigs ◽  
Plasma Metabolome ◽  
Continuous Feeding

scholarly journals Lean Gain Is Enhanced by a Leucine Pulse during Long‐Term Continuous Feeding in Neonatal Pigs

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Claire Boutry ◽  
Samer W. El‐Kadi ◽  
Agus Suryawan ◽  
Julia Steinhoff‐Wagner ◽  
Barbara Stoll ◽  
...  
Keyword(s):  
Neonatal Pigs ◽  
Continuous Feeding

scholarly journals Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs

2016 ◽  
Vol 310 (8) ◽  
pp. E699-E713 ◽  
Author(s):  
Claire Boutry ◽  
Samer W. El-Kadi ◽  
Agus Suryawan ◽  
Julia Steinhoff-Wagner ◽  
Barbara Stoll ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Enteral Feeding ◽  
Oral Feeding ◽  
Orogastric Tube ◽  
Neonatal Pigs ◽  
Lean Growth ◽  
Continuous Feeding ◽  
Pulsatile Delivery

Neonatal pigs are used as a model to study and optimize the clinical treatment of infants who are unable to maintain oral feeding. Using this model, we have shown previously that pulsatile administration of leucine during continuous feeding over 24 h via orogastric tube enhanced protein synthesis in skeletal muscle compared with continuous feeding alone. To determine the long-term effects of leucine pulses, neonatal piglets ( n = 11–12/group) were continuously fed formula via orogastric tube for 21 days, with an additional parenteral infusion of either leucine (CON + LEU; 800 μmol·kg−1·h−1) or alanine (CON + ALA) for 1 h every 4 h. The results show that body and muscle weights and lean gain were ∼25% greater, and fat gain was 48% lower in CON + LEU than CON + ALA; weights of other tissues were unaffected by treatment. Fractional protein synthesis rates in longissimus dorsi, gastrocnemius, and soleus muscles were ∼30% higher in CON + LEU compared with CON + ALA and were associated with decreased Deptor abundance and increased mTORC1, mTORC2, 4E-BP1, and S6K1 phosphorylation, SNAT2 abundance, and association of eIF4E with eIF4G and RagC with mTOR. There were no treatment effects on PKB, eIF2α, eEF2, or PRAS40 phosphorylation, Rheb, SLC38A9, v-ATPase, LAMTOR1, LAMTOR2, RagA, RagC, and LAT1 abundance, the proportion of polysomes to nonpolysomes, or the proportion of mRNAs encoding rpS4 or rpS8 associated with polysomes. Our results demonstrate that pulsatile delivery of a leucine supplement during 21 days of continuous enteral feeding enhances lean growth by stimulating the mTORC1-dependent translation initiation pathway, leading to protein synthesis in skeletal muscle of neonates.

scholarly journals Long‐term Leucine and BCAA Inclusion in a 30% Protein and Energy Restricted Diet Increases mTORC1 Signaling in Skeletal Muscle of Neonatal Pigs

2016 ◽  
Vol 30 (S1) ◽  
Author(s):  
Rodrigo Manjarin ◽  
Daniel A Columbus ◽  
Jessica Solis ◽  
Agus Suryawan ◽  
Adriana D Hernández‐García ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Restricted Diet ◽  
Neonatal Pigs ◽  
Mtorc1 Signaling

scholarly journals Long-Term Adaptation to High-Fat Diets Modifies the Nature and Output of Postprandial Intestinal Lymph Fatty Acid in Rats

1998 ◽  
Vol 128 (2) ◽  
pp. 185-192 ◽  
Author(s):  
Pascal Degrace ◽  
Claude Caselli ◽  
André Bernard
Keyword(s):  
Fatty Acid ◽  
High Fat ◽  
Intestinal Lymph ◽  
High Fat Diets ◽  
Fat Diets

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis
Keyword(s):  
Mental Health ◽  
Mental Disease ◽  
Brain Disorders ◽  
Social Stressors ◽  
Labor Education ◽  
Mental Diseases ◽  
Long Term Follow Up ◽  
Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

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