scholarly journals MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

10.3791/50565 ◽  
2013 ◽  
Author(s):  
Xueming Wu ◽  
Daniel Lindner ◽  
Guan-Ping Yu ◽  
Susann Brady-Kalnay ◽  
Zheng-Rong Lu
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Targeted Contrast Agent

scholarly journals MR Molecular Imaging of Prostate Cancer with a Peptide-Targeted Contrast Agent in a Mouse Orthotopic Prostate Cancer Model

2011 ◽  
Vol 29 (4) ◽  
pp. 953-960 ◽  
Author(s):  
Mingqian Tan ◽  
Susan M. Burden-Gulley ◽  
Wen Li ◽  
Xueming Wu ◽  
Daniel Lindner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Cancer Model ◽  
Targeted Contrast Agent ◽  
Prostate Cancer Model

scholarly journals First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer

2017 ◽  
Vol 52 (7) ◽  
pp. 419-427 ◽  
Author(s):  
Martijn Smeenge ◽  
François Tranquart ◽  
Christophe K. Mannaerts ◽  
Theo M. de Reijke ◽  
Marc J. van de Vijver ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Ultrasound Molecular Imaging ◽  
Molecular Contrast

scholarly journals A Peptide Targeted Contrast Agent Specific to Fibrin−Fibronectin Complexes for Cancer Molecular Imaging with MRI

2009 ◽  
Vol 20 (2) ◽  
pp. 402-402
Author(s):  
Furong Ye ◽  
Eun-Kee Jeong ◽  
Zhanjun Jia ◽  
Tianxin Yang ◽  
Dennis Parker ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Targeted Contrast Agent

Ultrasound Molecular Imaging of Transient Acute Myocardial Ischemia With a Clinically Translatable P- and E-Selectin Targeted Contrast Agent

2014 ◽  
Vol 49 (4) ◽  
pp. 224-235 ◽  
Author(s):  
Jean-Marc Hyvelin ◽  
Isabelle Tardy ◽  
Thierry Bettinger ◽  
Mathew von Wronski ◽  
Maria Costa ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Myocardial Ischemia ◽  
Contrast Agent ◽  
Acute Myocardial Ischemia ◽  
Ultrasound Molecular Imaging ◽  
Targeted Contrast Agent

Quantitative ultrasound molecular imaging by modeling the binding kinetics of targeted contrast agent

2017 ◽  
Vol 62 (6) ◽  
pp. 2449-2464 ◽  
Author(s):  
Simona Turco ◽  
Isabelle Tardy ◽  
Peter Frinking ◽  
Hessel Wijkstra ◽  
Massimo Mischi
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Quantitative Ultrasound ◽  
Binding Kinetics ◽  
Ultrasound Molecular Imaging ◽  
Kinetics Of ◽  
Targeted Contrast Agent

scholarly journals Real Time Ultrasound Molecular Imaging of Prostate Cancer with PSMA-targeted Nanobubbles

2019 ◽  
Author(s):  
Reshani Perera ◽  
Al de Leon ◽  
Xinning Wang ◽  
Yu Wang ◽  
Gopal Ramamurthy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Real Time ◽  
Sensitivity And Specificity ◽  
Cancer Detection ◽  
Contrast Enhanced ◽  
Ultrasound Molecular Imaging ◽  
Tumor Accumulation ◽  
Specific Membrane

AbstractContrast-enhanced ultrasound with microbubbles has shown promise in detection of prostate cancer (PCa), but sensitivity and specificity of detection remain challenging. Targeted nanoscale contrast agents with improved capability to accumulate in tumors may result in prolonged signal enhancement and improved detection of PCa with ultrasound. Here we report on a new nanobubble contrast agent that specifically targets prostate specific membrane antigen (PSMA) overexpressed in most prostate tumors. The PSMA-targeted bubbles (PSMA-NB) were utilized to simultaneously image dual flank PCa tumors (PSMA-positive PC3pip and PSMA-negative PC3flu) to examine whether the biomarker can be successfully detected and imaged using this probe in a mouse model. Results demonstrate that active targeting of NBs to PSMA rapidly and selectively enhances tumor accumulation and is critical for tumor retention of the contrast agent. Importantly, these processes could be visualized and quantified, in real time, with standard clinical ultrasound. Such demonstration of the immense yet underutilized potential of ultrasound in the area of molecular imaging can open the door to future opportunities for improving sensitivity and specificity of cancer detection using parametric NB-enhanced ultrasound imaging.

Spectral Polarization Imaging of Human Prostate Cancer Tissue Using a Near-infrared Receptor-targeted Contrast Agent

2005 ◽  
Vol 4 (4) ◽  
pp. 429-436 ◽  
Author(s):  
Y. Pu ◽  
W. B. Wang ◽  
G. C. Tang ◽  
F. Zeng ◽  
S. Achilefu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Contrast Agent ◽  
Near Infrared ◽  
Cancer Tissue ◽  
Polarization Imaging ◽  
Optical Window ◽  
Normal Tissues ◽  
Potential Marker ◽  
Prostate Cancer Tissue ◽  
Targeted Contrast Agent

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue “optical window”. The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

scholarly journals A Peptide Targeted Contrast Agent Specific to Fibrin-Fibronectin Complexes for Cancer Molecular Imaging with MRI

2008 ◽  
Vol 19 (12) ◽  
pp. 2300-2303 ◽  
Author(s):  
Furong Ye ◽  
Eun-Kee Jeong ◽  
Zhanjun Jia ◽  
Tianxin Yang ◽  
Denis Parker ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Targeted Contrast Agent
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