scholarly journals A Peptide Targeted Contrast Agent Specific to Fibrin−Fibronectin Complexes for Cancer Molecular Imaging with MRI

2009 ◽  
Vol 20 (2) ◽  
pp. 402-402
Author(s):  
Furong Ye ◽  
Eun-Kee Jeong ◽  
Zhanjun Jia ◽  
Tianxin Yang ◽  
Dennis Parker ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Targeted Contrast Agent

Ultrasound Molecular Imaging of Transient Acute Myocardial Ischemia With a Clinically Translatable P- and E-Selectin Targeted Contrast Agent

2014 ◽  
Vol 49 (4) ◽  
pp. 224-235 ◽  
Author(s):  
Jean-Marc Hyvelin ◽  
Isabelle Tardy ◽  
Thierry Bettinger ◽  
Mathew von Wronski ◽  
Maria Costa ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Myocardial Ischemia ◽  
Contrast Agent ◽  
Acute Myocardial Ischemia ◽  
Ultrasound Molecular Imaging ◽  
Targeted Contrast Agent

scholarly journals MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

10.3791/50565 ◽  
2013 ◽  
Author(s):  
Xueming Wu ◽  
Daniel Lindner ◽  
Guan-Ping Yu ◽  
Susann Brady-Kalnay ◽  
Zheng-Rong Lu
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Targeted Contrast Agent

Quantitative ultrasound molecular imaging by modeling the binding kinetics of targeted contrast agent

2017 ◽  
Vol 62 (6) ◽  
pp. 2449-2464 ◽  
Author(s):  
Simona Turco ◽  
Isabelle Tardy ◽  
Peter Frinking ◽  
Hessel Wijkstra ◽  
Massimo Mischi
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Quantitative Ultrasound ◽  
Binding Kinetics ◽  
Ultrasound Molecular Imaging ◽  
Kinetics Of ◽  
Targeted Contrast Agent

scholarly journals A Peptide Targeted Contrast Agent Specific to Fibrin-Fibronectin Complexes for Cancer Molecular Imaging with MRI

2008 ◽  
Vol 19 (12) ◽  
pp. 2300-2303 ◽  
Author(s):  
Furong Ye ◽  
Eun-Kee Jeong ◽  
Zhanjun Jia ◽  
Tianxin Yang ◽  
Denis Parker ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Targeted Contrast Agent

scholarly journals Liver Dysplasia: US Molecular Imaging with Targeted Contrast Agent Enables Early Assessment

Radiology ◽  
2013 ◽  
Vol 267 (2) ◽  
pp. 487-495 ◽  
Author(s):  
Christoph Grouls ◽  
Maximillian Hatting ◽  
Anne Rix ◽  
Sibylle Pochon ◽  
Wiltrud Lederle ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Early Assessment ◽  
Targeted Contrast Agent

scholarly journals MR Molecular Imaging of Prostate Cancer with a Peptide-Targeted Contrast Agent in a Mouse Orthotopic Prostate Cancer Model

2011 ◽  
Vol 29 (4) ◽  
pp. 953-960 ◽  
Author(s):  
Mingqian Tan ◽  
Susan M. Burden-Gulley ◽  
Wen Li ◽  
Xueming Wu ◽  
Daniel Lindner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Cancer Model ◽  
Targeted Contrast Agent ◽  
Prostate Cancer Model

scholarly journals First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer

2017 ◽  
Vol 52 (7) ◽  
pp. 419-427 ◽  
Author(s):  
Martijn Smeenge ◽  
François Tranquart ◽  
Christophe K. Mannaerts ◽  
Theo M. de Reijke ◽  
Marc J. van de Vijver ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Ultrasound Molecular Imaging ◽  
Molecular Contrast

scholarly journals Investigation of Specific Targeting of Triptorelin-Conjugated Dextran-Coated Magnetite Nanoparticles as a Targeted Probe in GnRH+ Cancer Cells in MRI

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Milad Yousefvand ◽  
Zahra Mohammadi ◽  
Farzaneh Ghorbani ◽  
Rasoul Irajirad ◽  
Hormoz Abedi ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Tumor Targeting ◽  
Tumor Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Gnrh Receptors ◽  
Imaging Probes ◽  
Magnetic Resonance Imaging Mri ◽  
Targeted Contrast Agent

In recent years, the conjugation of superparamagnetic iron oxide nanoparticles (SPIONs), as tumor-imaging probes for magnetic resonance imaging (MRI), with tumor targeting peptides possesses promising advantages for specific delivery of MRI agents. The objective of the current study was to design a targeted contrast agent for MRI based on Fe3O4 nanoparticles conjugated triptorelin (SPION@triptorelin), which has a great affinity to the GnRH receptors. The SPIONs-coated carboxymethyl dextran (SPION@CMD) conjugated triptorelin (SPION@CMD@triptorelin) were synthesized using coprecipitation method and characterized by DLS, TEM, XRD, FTIR, Zeta, and VSM techniques. The relaxivities of synthetized formulations were then calculated using a 1.5 Tesla clinical magnetic field. MRI, quantitative cellular uptake, and cytotoxicity level of them were estimated. The characterization results confirmed that the formation of SPION@CMD@triptorelin has been conjugated with a suitable size. Our results demonstrated the lack of cellular cytotoxicity of SPION@CMD@triptorelin, and it could increase the cellular uptake of SPIONs to MDA-MB-231 cancer cells 6.50-fold greater than to SPION@CMD at the concentration of 75 μM. The relaxivity calculations for SPION@CMD@triptorelin showed a suitable r2 and r2/r1 with values of 31.75 mM−1·s−1 and 10.26, respectively. Our findings confirm that triptorelin-targeted SPIONs could provide a T2-weighted probe contrast agent that has the great potential for the diagnosis of GnRH-positive cancer in MRI.

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