scholarly journals Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats

10.3791/50397 ◽  
2013 ◽  
Author(s):  
Sarah Jeuthe ◽  
Darach O H-Ici ◽  
Ulrich Kemnitz ◽  
Thore Dietrich ◽  
Bernhard Schnackenburg ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Small Animal ◽  
Inversion Recovery ◽  
Myocardial Morphology

Pulmonary perfusion quantification with flow-sensitive inversion recovery (FAIR) UTE MRI in small animal imaging

2016 ◽  
Vol 29 (12) ◽  
pp. 1791-1799 ◽  
Author(s):  
Marta Tibiletti ◽  
Andrea Bianchi ◽  
Detlef Stiller ◽  
Volker Rasche
Keyword(s):  
Small Animal Imaging ◽  
Small Animal ◽  
Inversion Recovery ◽  
Pulmonary Perfusion ◽  
Animal Imaging ◽  
Perfusion Quantification

scholarly journals Small Animal Look-Locker Inversion Recovery (SALLI) for Simultaneous Generation of Cardiac T1 Maps and Cine and Inversion Recovery–prepared Images at High Heart Rates: Initial Experience

Radiology ◽  
2011 ◽  
Vol 261 (1) ◽  
pp. 258-265 ◽  
Author(s):  
Daniel R. Messroghli ◽  
Sarah Nordmeyer ◽  
Martin Buehrer ◽  
Sebastian Kozerke ◽  
Thore Dietrich ◽  
...  
Keyword(s):  
Small Animal ◽  
Inversion Recovery ◽  
Initial Experience ◽  
Simultaneous Generation ◽  
Heart Rates ◽  
And Inversion

Cardioprotective effect of the secretome of Sca-1+ and Sca-1− cells in heart failure: not equal, but equally important?

2019 ◽  
Vol 116 (3) ◽  
pp. 566-575 ◽  
Author(s):  
Stephanie Könemann ◽  
Luiz V Sartori ◽  
Stefan Gross ◽  
Stefan Hadlich ◽  
Jens-Peter Kühn ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Function ◽  
Progenitor Cells ◽  
Small Animal ◽  
Cell Types ◽  
Cardiac Cells ◽  
Enzyme Linked Immunosorbent Assay ◽  
Paracrine Effects ◽  
Paracrine Effect ◽  
Differentiated Cells

Abstract Aims Both progenitor and differentiated cells were previously shown to secrete cardioprotective substances, but so far there has been no direct comparison of the paracrine effects of the two cell types on heart failure. The study sought to compare the paracrine effect of selected progenitors and the corresponding non-progenitor mononuclear cardiac cells on the cardiac function of transgenic heart failure mice. In addition, we aimed to further enhance the paracrine effect of the cells via pretreatment with the heart failure mediator aldosterone. Methods and results Transgenic heart failure mice were injected with the supernatant of murine cardiac stem cell antigen-1 positive (Sca-1+) and negative (Sca-1−) cells with or without aldosterone pretreatment. Cardiac function was determined using small animal magnetic resonance imaging. In addition, heart failure markers were determined using enzyme-linked immunosorbent assay, RT–PCR, and bead-based multiplexing assay. While only the secretome of aldosterone pretreated Sca-1+ cells led to a significant improvement in cardiac function, N-terminal pro brain natriuretic peptide plasma levels were significantly lower and galectin-1 levels significantly higher in mice that were treated with either kind of secretome compared with untreated controls. Conclusion In this first direct comparison of the paracrine effects of progenitor cells and a heterogeneous population of mononuclear cardiac cells the supernatants of both cell types showed cardioprotective properties which might be of great relevance for endogenous repair. During heart failure raised aldosterone levels might further increase the paracrine effect of progenitor cells.

scholarly journals Small animal look-locker inversion recovery (SALLI)

2011 ◽  
Vol 13 (S1) ◽  
Author(s):  
Daniel Messroghli ◽  
Sarah Nordmeyer ◽  
Martin Buehrer ◽  
Sebastian Kozerke ◽  
Thore Dietrich ◽  
...  
Keyword(s):  
Small Animal ◽  
Inversion Recovery

scholarly journals Assessment of Diffuse Myocardial Fibrosis in Rats Using Small-Animal Look-Locker Inversion Recovery T1 Mapping

2011 ◽  
Vol 4 (6) ◽  
pp. 636-640 ◽  
Author(s):  
Daniel R. Messroghli ◽  
Sarah Nordmeyer ◽  
Thore Dietrich ◽  
Olaf Dirsch ◽  
Elena Kaschina ◽  
...  
Keyword(s):  
Myocardial Fibrosis ◽  
T1 Mapping ◽  
Small Animal ◽  
Diffuse Myocardial Fibrosis ◽  
Inversion Recovery

scholarly journals Assessing Myocardial Architecture: The Challenges and Controversies

2020 ◽  
Vol 7 (4) ◽  
pp. 47
Author(s):  
Peter Agger ◽  
Robert S. Stephenson
Keyword(s):  
Cardiac Function ◽  
Cardiac Myocytes ◽  
Important Determinant ◽  
Normal Vector ◽  
Orientation Analysis ◽  
Future Design ◽  
The Future ◽  
Myocardial Morphology ◽  
Myocardial Architecture ◽  
Do So

In recent decades, investigators have strived to describe and quantify the orientation of the cardiac myocytes in an attempt to classify their arrangement in healthy and diseased hearts. There are, however, striking differences between the investigations from both a technical and methodological standpoint, thus limiting their comparability and impeding the drawing of appropriate physiological conclusions from the structural assessments. This review aims to elucidate these differences, and to propose guidance to establish methodological consensus in the field. The review outlines the theory behind myocyte orientation analysis, and importantly has identified pronounced differences in the definitions of otherwise widely accepted concepts of myocytic orientation. Based on the findings, recommendations are made for the future design of studies in the field of myocardial morphology. It is emphasised that projection of myocyte orientations, before quantification of their angulation, introduces considerable bias, and that angles should be assessed relative to the epicardial curvature. The transmural orientation of the cardiomyocytes should also not be neglected, as it is an important determinant of cardiac function. Finally, there is considerable disagreement in the literature as to how the orientation of myocardial aggregates should be assessed, but to do so in a mathematically meaningful way, the normal vector of the aggregate plane should be utilised.

scholarly journals Myocardial Morphology and Cardiac Function in Rats With Renal Failure

2000 ◽  
Vol 64 (8) ◽  
pp. 606-610 ◽  
Author(s):  
Nobuo Hatori ◽  
Niilo Havu ◽  
Claes Hofman-Bang ◽  
Naomi Clyne ◽  
S.Kenneth Pehrsson
Keyword(s):  
Renal Failure ◽  
Cardiac Function ◽  
Myocardial Morphology
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