scholarly journals Myocardial Morphology and Cardiac Function in Rats With Renal Failure

2000 ◽  
Vol 64 (8) ◽  
pp. 606-610 ◽  
Author(s):  
Nobuo Hatori ◽  
Niilo Havu ◽  
Claes Hofman-Bang ◽  
Naomi Clyne ◽  
S.Kenneth Pehrsson
Keyword(s):  
Renal Failure ◽  
Cardiac Function ◽  
Myocardial Morphology

scholarly journals Impairment of cardiac function and energetics in experimental renal failure.

1993 ◽  
Vol 92 (6) ◽  
pp. 2934-2940 ◽  
Author(s):  
A E Raine ◽  
A M Seymour ◽  
A F Roberts ◽  
G K Radda ◽  
J G Ledingham
Keyword(s):  
Renal Failure ◽  
Cardiac Function ◽  
Experimental Renal Failure

IMPACT OF RENAL TRANSPLANTATION ON CARDIAC FUNCTION IN PATIENTS WITH CHRONIC RENAL FAILURE

2010 ◽  
Vol 90 ◽  
pp. 689
Author(s):  
A. Sharma ◽  
M. Minz ◽  
K. L. GUPTA ◽  
R. M. Kumar ◽  
N. PANDIT
Keyword(s):  
Renal Failure ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Cardiac Function

scholarly journals Assessment of cardiac function by Doppler echocardiography in patients with diabetic end-stage renal failure. Response to the leg raising maneuver.

1994 ◽  
Vol 27 (12) ◽  
pp. 1469-1474
Author(s):  
Tadashi Tamura ◽  
Makoto Ohta ◽  
Michimasa Soejima ◽  
Shigeaki Satou ◽  
Kennichi Sugimoto ◽  
...  
Keyword(s):  
Renal Failure ◽  
Cardiac Function ◽  
Doppler Echocardiography ◽  
End Stage Renal Failure ◽  
End Stage

scholarly journals Evaluation of cardiac function during hemodialysis in patients with chronic renal failure due to diabetic nephropathy

1985 ◽  
Vol 18 (2) ◽  
pp. 149-154
Author(s):  
Tsuneo Murasawa ◽  
Makoto Taguchi ◽  
Tohri Suzuki ◽  
Yoshiki Hirofuji ◽  
Yusuke Fujii ◽  
...  
Keyword(s):  
Renal Failure ◽  
Diabetic Nephropathy ◽  
Chronic Renal Failure ◽  
Cardiac Function

Abstract 342: Increased Myocardial Ischemic/Reperfusion Injury in Renal Failure Involves Cardiac Adiponectin Signal Deficiency

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Ling Tao ◽  
Yanbin Song ◽  
Junyi Zhang ◽  
Weidong Huang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Renal Failure ◽  
Cardiac Function ◽  
Infarct Size ◽  
Reperfusion Injury ◽  
Tunel Staining ◽  
Ischemic Reperfusion Injury ◽  
Ischemic Reperfusion ◽  
Nitrative Stress ◽  
Cardiovascular Morbidity And Mortality

Chronic kidney disease (CKD) is associated with increased incidence as well as adverse outcomes of acute myocardial infarction. Adiponectin (APN), known as a cardioprotective factor, has been observed decreased in cardiovascular disorders including myocardial infarction. However, plasma APN levels are significantly increased and are inversely related to the risk of cardiovascular morbidity and mortality in patients with CKD. The mechanism underlying the paradoxical relationship between high APN and poor cardiac outcome remains unclear. In the present study, subtotal nephrectomized (SN) and sham-operated mice were randomly subjected to a 30 min myocardial ischemia followed by 24 hrs reperfusion with or without human recombinant gAd treatment (2μg/g/d, 7days). Compared with sham WT mice, SN mice displayed significantly depressed cardiac function and enlarged infarct size following MI/R. TUNEL staining and caspase-3 activity assay demonstrated markedly increased cardiomyocyte apoptosis in SN mice following MI/R. What’s more, increased plasma total APN levels was observed in SN mice 4 weeks after MI/R. Importantly, SN caused further decreased cardiac function and larger infarct size in APN knockout (KO) mice compared with those in SN WT mice subjected to MI/R. However, gAd treatment significantly enhanced cardiac function and reduced infarct size and apoptosis in both WT and KO mice. Further, we found that SN KO mice showed more reduced eNOS phosphorylation, upregulated iNOS expression and ·O 2 - production and consequently increased peroxynitrite production in cardiac tissue than SN WT animals, which can be partly reversed by administration of gAd. AdipoR1 expression was reduced 4-wk after SN whereas AdipoR2 showed no significant change. More importantly, AMPK activation was also inhibited after SN and exogenous gAd supplementation reversed this change. In conclusion, the present study demonstrates that renal dysfunction increases cardiac susceptibility to ischemic/reperfusion injury, which is associated with downregulated APN/AdipoR1/AMPK signaling and increased oxidative/nitrative stress in local myocardium, and provides the first evidence for the benefits of exogenous supplement of APN on cardiac outcomes in renal failure.

Cardiac Function in Chronic Renal Failure Before and After Hemodialysis

Cardiology ◽  
1973 ◽  
Vol 58 (2) ◽  
pp. 109-117 ◽  
Author(s):  
D. Strangfeld ◽  
K.H. Günther ◽  
Renate Bohm ◽  
Helga Günther ◽  
K. Buchali ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiac Function ◽  
Before And After
Sign in / Sign up

Export Citation Format

Share Document