High-resolution photoacoustic microscope for rat brain imaging in vivo

2010 ◽  
Vol 8 (6) ◽  
pp. 609-611 ◽  
Author(s):  
杨孝全 Xiaoquan Yang ◽  
蔡鑫 Xin Cai ◽  
Konstantin Maslov Konstantin Maslov ◽  
汪立宏 Lihong Wang ◽  
骆清铭 Qingming Luo
Keyword(s):  
High Resolution ◽  
Brain Imaging ◽  
Rat Brain

scholarly journals Cross-validation study between the HRRT and the PET component of the SIGNA PET/MRI system with focus on neuroimaging

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Julia G. Mannheim ◽  
Ju-Chieh (Kevin) Cheng ◽  
Nasim Vafai ◽  
Elham Shahinfard ◽  
Carolyn English ◽  
...  
Keyword(s):  
High Resolution ◽  
Brain Imaging ◽  
Validation Study ◽  
Cross Validation ◽  
Whole Body ◽  
Line Profiles ◽  
Time Activity ◽  
Phantom Data ◽  
Two Systems

Abstract Background The Siemens high-resolution research tomograph (HRRT - a dedicated brain PET scanner) is to this day one of the highest resolution PET scanners; thus, it can serve as useful benchmark when evaluating performance of newer scanners. Here, we report results from a cross-validation study between the HRRT and the whole-body GE SIGNA PET/MR focusing on brain imaging. Phantom data were acquired to determine recovery coefficients (RCs), % background variability (%BG), and image voxel noise (%). Cross-validation studies were performed with six healthy volunteers using [11C]DTBZ, [11C]raclopride, and [18F]FDG. Line profiles, regional time-activity curves, regional non-displaceable binding potentials (BPND) for [11C]DTBZ and [11C]raclopride scans, and radioactivity ratios for [18F]FDG scans were calculated and compared between the HRRT and the SIGNA PET/MR. Results Phantom data showed that the PET/MR images reconstructed with an ordered subset expectation maximization (OSEM) algorithm with time-of-flight (TOF) and TOF + point spread function (PSF) + filter revealed similar RCs for the hot spheres compared to those obtained on the HRRT reconstructed with an ordinary Poisson-OSEM algorithm with PSF and PSF + filter. The PET/MR TOF + PSF reconstruction revealed the highest RCs for all hot spheres. Image voxel noise of the PET/MR system was significantly lower. Line profiles revealed excellent spatial agreement between the two systems. BPND values revealed variability of less than 10% for the [11C]DTBZ scans and 19% for [11C]raclopride (based on one subject only). Mean [18F]FDG ratios to pons showed less than 12% differences. Conclusions These results demonstrated comparable performances of the two systems in terms of RCs with lower voxel-level noise (%) present in the PET/MR system. Comparison of in vivo human data confirmed the comparability of the two systems. The whole-body GE SIGNA PET/MR system is well suited for high-resolution brain imaging as no significant performance degradation was found compared to that of the reference standard HRRT.

In vivo rat brain imaging using a short multimode fiber probe

2020 ◽  
Author(s):  
Kai Eto ◽  
Masuta Junpei ◽  
Reiko Kurotani ◽  
Hiroyuki Abe ◽  
Izumi Nishidate ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Rat Brain ◽  
Multimode Fiber ◽  
Fiber Probe

Bright AIEgen–Protein Hybrid Nanocomposite for Deep and High‐Resolution In Vivo Two‐Photon Brain Imaging

2019 ◽  
Vol 29 (29) ◽  
pp. 1902717 ◽  
Author(s):  
Shaowei Wang ◽  
Fang Hu ◽  
Yutong Pan ◽  
Lai Guan Ng ◽  
Bin Liu
Keyword(s):  
High Resolution ◽  
Brain Imaging ◽  
Hybrid Nanocomposite ◽  
Two Photon

scholarly journals In vivo high-resolution localized 1 H MR spectroscopy in the awake rat brain at 7 T

2012 ◽  
Vol 69 (4) ◽  
pp. 937-943 ◽  
Author(s):  
Su Xu ◽  
Yadong Ji ◽  
Xi Chen ◽  
Yihong Yang ◽  
Rao P. Gullapalli ◽  
...  
Keyword(s):  
High Resolution ◽  
Rat Brain ◽  
Mr Spectroscopy ◽  
Awake Rat

In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET)

10.1038/76509 ◽  
2000 ◽  
Vol 18 (6) ◽  
pp. 655-660 ◽  
Author(s):  
Harley I. Kornblum ◽  
Dalia M. Araujo ◽  
Alexander J. Annala ◽  
Keith J. Tatsukawa ◽  
Michael E. Phelps ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
High Resolution ◽  
Rat Brain ◽  
In Vivo Imaging ◽  
Emission Tomography ◽  
Neuronal Activation ◽  
Positron Emission
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