In vivo rat brain imaging using a short multimode fiber probe

2020 ◽  
Author(s):  
Kai Eto ◽  
Masuta Junpei ◽  
Reiko Kurotani ◽  
Hiroyuki Abe ◽  
Izumi Nishidate ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Rat Brain ◽  
Multimode Fiber ◽  
Fiber Probe

scholarly journals Sectional Imaging of in vivo Rat Brain Using Short Multimode Fiber Probe

2020 ◽  
Vol 41 (1) ◽  
pp. 9-17
Author(s):  
Manabu Sato ◽  
Kai Eto ◽  
Junpei Masuta ◽  
Kenji Inoue ◽  
Reiko Kurotani ◽  
...  
Keyword(s):  
Rat Brain ◽  
Multimode Fiber ◽  
Fiber Probe ◽  
Sectional Imaging

Rat brain imaging using full field optical coherence microscopy with short multimode fiber probe

2017 ◽  
Author(s):  
Manabu Sato ◽  
Daisuke Saito ◽  
Reiko Kurotani ◽  
Hiroyuki Abe ◽  
Satoko Kawauchi ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Rat Brain ◽  
Optical Coherence ◽  
Multimode Fiber ◽  
Optical Coherence Microscopy ◽  
Fiber Probe ◽  
Full Field

scholarly journals In Vivo Rat Brain Imaging through Full-Field Optical Coherence Microscopy Using an Ultrathin Short Multimode Fiber Probe

2019 ◽  
Vol 9 (2) ◽  
pp. 216 ◽  
Author(s):  
Manabu Sato ◽  
Kai Eto ◽  
Junpei Masuta ◽  
Kenji Inoue ◽  
Reiko Kurotani ◽  
...  
Keyword(s):  
Rat Brain ◽  
Three Dimensional ◽  
Nerve Fibers ◽  
Outer Diameter ◽  
Optical Coherence ◽  
Multimode Fiber ◽  
Core Diameter ◽  
Optical Coherence Microscopy ◽  
Full Field

We demonstrate full-field optical coherence microscopy (OCM) using an ultrathin forward-imaging short multimode fiber (SMMF) probe with a core diameter of 50 μm, outer diameter of 125 μm, and length of 7.4 mm, which is a typical graded-index multimode fiber used for optical communications. The axial and lateral resolutions were measured to be 2.14 μm and 2.3 μm, respectively. By inserting the SMMF 4 mm into the cortex of an in vivo rat brain, scanning was performed to a depth of 147 μm from the SMMF facet with a field of view of 47 μm. Three-dimensional (3D) OCM images were obtained at depths ranging from approximately 20 μm to 90 μm. Based on the morphological information of the resliced 3D images and the dependence of the integration of the OCM image signal on the insertion length, the obtained 3D information of nerve fibers has been presented.

scholarly journals Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Sebastian A. Vasquez-Lopez ◽  
Raphaël Turcotte ◽  
Vadim Koren ◽  
Martin Plöschner ◽  
Zahid Padamsey ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Brain Imaging ◽  
Spatial Resolution ◽  
Multimode Fiber ◽  
Deep Brain

Fiber spectral domain optical coherence tomography for in vivo rat brain imaging

2010 ◽  
Author(s):  
Y. Xie ◽  
T. Bonin ◽  
S. Loeffler ◽  
G. Huettmann ◽  
V. Tronnier ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Brain Imaging ◽  
Rat Brain ◽  
Spectral Domain ◽  
Optical Coherence

High-resolution photoacoustic microscope for rat brain imaging in vivo

2010 ◽  
Vol 8 (6) ◽  
pp. 609-611 ◽  
Author(s):  
杨孝全 Xiaoquan Yang ◽  
蔡鑫 Xin Cai ◽  
Konstantin Maslov Konstantin Maslov ◽  
汪立宏 Lihong Wang ◽  
骆清铭 Qingming Luo
Keyword(s):  
High Resolution ◽  
Brain Imaging ◽  
Rat Brain

Sigma receptors mediate potent neuroprotection in vivo and inhibit neuronal depolarisation and swelling in rat brain slices

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S468-S468
Author(s):  
Jennifer K Callaway ◽  
Christine Molnar ◽  
Song T Yao ◽  
Bevyn Jarrott ◽  
R David Andrew
Keyword(s):  
Rat Brain ◽  
Brain Slices ◽  
Sigma Receptors

In vivo diffusion tensor imaging of the neonatal rat brain development

2013 ◽  
Vol 44 (S 01) ◽  
Author(s):  
M Breu ◽  
D Reisinger ◽  
D Wu ◽  
Y Zhang ◽  
A Fatemi ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Brain Development ◽  
Rat Brain ◽  
Diffusion Tensor ◽  
Neonatal Rat ◽  
Neonatal Rat Brain

In silico and in vivo study of radio-iodinated nefiracetam as a radiotracer for brain imaging in mice

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
M. H. Sanad ◽  
A. B. Farag ◽  
S. F. A. Rizvi
Keyword(s):  
Brain Imaging ◽  
Radiochemical Purity ◽  
High Yield ◽  
High Uptake ◽  
Oxidizing Agent ◽  
Receptor Ligand ◽  
Nootropic Agent ◽  
Biodistribution Studies

Abstract This study presents development and characterization of a radiotracer, [125I]iodonefiracetam ([125I]iodoNEF). Labeling with high yield and radiochemical purity was achieved through the formation of a [125I]iodoNEF radiotracer after investigating many factors like oxidizing agent content (chloramines-T (Ch-T)), substrate amount (Nefiracetam (NEF)), pH of reaction mixture, reaction time and temperature. Nefiracetam (NEF) is known as nootropic agent, acting as N-methyl-d-aspartic acid receptor ligand (NMDA). The radiolabeled compound was stable, and exhibited the logarithm of the partition coefficient (log p) value of [125I]iodonefiracetam as 1.85 (lipophilic). Biodistribution studies in normal mice confirmed the suitability of the [125I]iodoNEF radiotracer as a novel tracer for brain imaging. High uptake of 8.61 ± 0.14 percent injected dose/g organ was observed in mice

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