scholarly journals Macular Pigments

2017 ◽  
pp. 112-115
Keyword(s):  
Macular Degeneration ◽  
Light Absorption ◽  
Short Wavelength ◽  
Protective Role ◽  
Age Related Macular Degeneration ◽  
Diagnostic Systems ◽  
Absorption Properties ◽  
Fundus Imaging ◽  
Age Related ◽  
The World

Yellowish pigmentation of the macula results from macular pigments called lutein, zeaxanthin, and mesozeaxanthin. Anatomical, biochemical (antioxidative) and optical (short-wavelength blue light absorption) properties of the macular pigments have increased the interest in vision and macular health. Macular pigments have been shown to have a protective role for age-related macular degeneration which is one of the leading causes of blindness all over the world. Macular pigments play an important role in the evaluation of the fundus imaging and diagnostic systems such as autofluorescence and angiography.

scholarly journals Involvement of Nrf2 in Ocular Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-18 ◽  
Author(s):  
Shehzad Batliwala ◽  
Christy Xavier ◽  
Yang Liu ◽  
Hongli Wu ◽  
Iok-Hou Pang
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Macular Degeneration ◽  
Human Body ◽  
Age Related Macular Degeneration ◽  
Ocular Diseases ◽  
Checks And Balances ◽  
Age Related ◽  
The World

The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system—the Keap1-Nrf2-ARE pathway—on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.

scholarly journals The short-wavelength mechanisms of Stiles in age-related macular degeneration

1998 ◽  
Vol 38 (21) ◽  
pp. 3433-3440
Author(s):  
J.P Hubschman ◽  
J.L Vola ◽  
J Conrath ◽  
P Berros ◽  
F Hougrand
Keyword(s):  
Macular Degeneration ◽  
Short Wavelength ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration

2008 ◽  
Vol 93 (5) ◽  
pp. 603-609 ◽  
Author(s):  
I Gorczynska ◽  
V J Srinivasan ◽  
L N Vuong ◽  
R W S Chen ◽  
J J Liu ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Fundus Imaging ◽  
Age Related ◽  
Retinal Pathology

scholarly journals Incidence, progression and risk factors of age-related macular degeneration in 35–95-year-old individuals from three jointly designed German cohort studies

2022 ◽  
Vol 7 (1) ◽  
pp. e000912
Author(s):  
Caroline Brandl ◽  
Felix Günther ◽  
Martina E Zimmermann ◽  
Kathrin I Hartmann ◽  
Gregor Eberlein ◽  
...  
Keyword(s):  
Risk Factor ◽  
Macular Degeneration ◽  
Population Based ◽  
Healthcare Management ◽  
Age Related Macular Degeneration ◽  
Severity Scale ◽  
Fundus Imaging ◽  
Age Related ◽  
Age Range

ObjectiveTo estimate age-related macular degeneration (AMD) incidence/progression across a wide age range.Methods and analysisAMD at baseline and follow-up (colour fundus imaging, Three Continent AMD Consortium Severity Scale, 3CACSS, clinical classification, CC) was assessed for 1513 individuals aged 35–95 years at baseline from three jointly designed population-based cohorts in Germany: Kooperative Gesundheitsforschung in der Region Augsburg (KORA-Fit, KORA-FF4) and Altersbezogene Untersuchungen zur Gesundheit der Universität Regensburg (AugUR) with 18-year, 14-year or 3-year follow-up, respectively. Baseline assessment included lifestyle, metabolic and genetic markers. We derived cumulative estimates, rates and risk factor association for: (1) incident early AMD, (2) incident late AMD among no AMD at baseline (definition 1), (3) incident late AMD among no/early AMD at baseline (definition 2), (4) progression from early to late AMD.ResultsIncidence/progression increased by age, except progression in 70+-year old. We observed 35–55-year-old with 3CACSS-based early AMD who progressed to late AMD. Predominant risk factor for incident late AMD definition 2 was early AMD followed by genetics and smoking. When separating incident late AMD definition 1 from progression (instead of combined as incident late AMD definition 2), estimates help judge an individual’s risk based on age and (3CACSS) early AMD status: for example, for a 65-year old, 3-year late AMD risk with no or early AMD is 0.5% or 7%, 3-year early AMD risk is 3%; for an 85-year old, these numbers are 0.5%, 21%, 12%, respectively. For CC-based ‘early/intermediate’ AMD, incidence was higher, but progression was lower.ConclusionWe provide a practical guide for AMD risk for ophthalmology practice and healthcare management and document a late AMD risk for individuals aged <55 years.

scholarly journals Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Rasa Liutkeviciene ◽  
Alvita Vilkeviciute ◽  
Greta Gedvilaite ◽  
Kriste Kaikaryte ◽  
Loresa Kriauciuniene
Keyword(s):  
Macular Degeneration ◽  
Protective Factor ◽  
Protective Role ◽  
Age Related Macular Degeneration ◽  
Nucleotide Polymorphisms ◽  
Exudative Amd ◽  
Age Related ◽  
Increased Risk ◽  
And Gender ◽  
The Impact

Background. To determine the impact of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 genotypes on the development of age-related macular degeneration (AMD) in the Lithuanian population. Methods. A total of 916 subjects were examined: 309 patients with early AMD, 301 patients with exudative AMD, and 306 healthy controls. The genotyping of HTRA1 rs11200638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 was carried out using the RT-PCR method. Results. Our study showed that single-nucleotide polymorphisms rs3793784 and rs11200638 were associated with increased odds of early and exudative AMD, and the variant in KCTD10 (rs56209061) was found to be associated with decreased odds of early and exudative AMD development after adjustments for age and gender in early AMD analysis and after adjustments only for age in exudative AMD. The haplotype containing two minor alleles C-A and the G-A haplotype in rs3793784-rs11200638 were statistically significantly associated with an increased risk of exudative AMD development after adjustment for age, while the G-G haplotype showed a protective role against early and exudative AMD and the haplotype C-G in rs3793784-rs11200638 was associated with a decreased risk only of exudative AMD development. Conclusions. Our study identified two markers, rs11200638 and rs3793784, as risk factors for early and exudative AMD, and one marker, rs56209061, as a protective factor for early and exudative AMD development. The haplotypes constructed of rs3793784-rs11200638 were found to be associated with AMD development, as well.

scholarly journals Revisión Bibliográfica: Degeneración Macular Relacionada con la Edad. Prevención y Tratamiento Temprano

2018 ◽  
Vol 10 (2) ◽  
pp. 145-149
Author(s):  
Katerine Leonor Ávila Heras ◽  
Yadira Karina Carrillo Mora ◽  
Sofía Nathaly Cely Jadan ◽  
Marisa Arcos
Keyword(s):  
Folic Acid ◽  
Macular Degeneration ◽  
Health Personnel ◽  
Age Related Macular Degeneration ◽  
World Health ◽  
Central Vision ◽  
Age Related ◽  
The World ◽  
Prevention And Treatment ◽  
Health Organization

Age-related macular degeneration is one of the diseases that affect the macula in people over 50 years of age, due to the existence of different multifactorial neurodegenerative changes that can lead to the loss of central vision. According to the World Health Organization there is a prevalence of 4 % worldwide; it is related of 7 % of the blindness and 3 %; Clinically it is manifested by two forms, the atrophic or dry and the exudative or wet. It has been shown that foods rich in antioxidants, folic acid and zinc help reduce this disease in early stages. This review aims to update health personnel about the prevention and treatment of age-related macular degeneration.

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