Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population

Margaret ILOMUANYA; Olusola AYANLOWO; Uloma UBANI-UKOMA; Modupe OLOGUNAGBA; Richard ODAFI

doi:10.37662/jpt.2020.5

Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population

Journal of Pharmaceutical Technolgy ◽

10.37662/jpt.2020.5 ◽

2020 ◽

Vol 1 (2) ◽

pp. 40-45

Author(s):

Margaret ILOMUANYA ◽

Olusola AYANLOWO ◽

Uloma UBANI-UKOMA ◽

Modupe OLOGUNAGBA ◽

Richard ODAFI

Keyword(s):

Safety Evaluation ◽

Testing Methods ◽

Nigerian Population

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Toxicological and Safety Evaluation of Bacillus subtilis Strain Tpb55

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.807-809.1947 ◽

2013 ◽

Vol 807-809 ◽

pp. 1947-1953

Author(s):

Cheng Wei Zhang ◽

Yu Qin Zhang ◽

Jia Ming Gao

Keyword(s):

Animal Experiments ◽

Safety Evaluation ◽

Micronucleus Assay ◽

Mutagenic Effect ◽

Control Group ◽

Dermal Toxicity ◽

Testing Methods ◽

Oral Toxicity ◽

Rabbit Skin ◽

Low Toxicity

The toxicological safety of Bacillus subtilis strain Tpb55 was evaluated according to the Toxicological Testing Methods for Pesticide Registration (GB 15670~1995) by animal experiments. The results showed that the LD50 of acute oral toxicity of Tpb55 was greater than 5,000 mg/kg; the acute dermal toxicity LD50 was over 5,000 mg/kg. No irritation to rabbit skin and eye was found, and the average index of eye irritation after 48 h was 0. Thus, it can be concluded that the acute toxicity of Tpb55 administered orally or dermally was proved to be at a lower level, with no irritations to rabbit skin and eye. Its dermal hypersusceptibility rate was zero for the guinea pigs, so that Tpb55 belongs to a weak sensitizer of grade I. There were no significant differences between the experimental groups and the control group in micronucleus assay and sperm shape abnormality. Therefore, Tpb55 strain is a safe biological bacterium with low toxicity, no irritation, no sensitization and no mutagenic effect.

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