scholarly journals A new synthetic protocol for coumarin amino acid

2013 ◽  
Vol 9 ◽  
pp. 254-259 ◽  
Author(s):  
Xinyi Xu ◽  
Xiaosong Hu ◽  
Jiangyun Wang
Keyword(s):  
Amino Acid ◽  
Fluorescent Probe ◽  
Synthetic Method ◽  
Fluorescent Amino Acid ◽  
Racemic Amino Acid ◽  
Derivatives Of ◽  
Coumarin Amino Acid

The hydrochloride of the racemic amino acid (2-(7-hydroxycoumarin-4-yl)ethyl)glycine, which can serve as a fluorescent probe in proteins, and two halogen derivatives of it, were synthesized by using a new synthetic protocol in five steps. It is less costly and relatively easy to prepare this kind of fluorescent amino acid with the new synthetic method. Furthermore, it can be applied to synthesize other derivatives of the coumarin amino acid with some specific properties.

scholarly journals Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine

2010 ◽  
Vol 6 ◽  
Author(s):  
Manfred Braun ◽  
Torsten Dittrich
Keyword(s):  
Acetic Acid ◽  
Amino Acid ◽  
Fluorescent Probe ◽  
Fluorescent Amino Acid ◽  
Racemic Amino Acid

The hydrochloride of the racemic amino acid (7-hydroxycoumarin-4-yl)ethylglycine, a versatile fluorescent probe in proteins, has been synthesized in five steps from commercially available (7-hydroxycoumarin-4-yl)acetic acid. The key step involves the alkylation of a glycine–enolate equivalent.

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

scholarly journals Selective Synthesis of N-Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1813
Author(s):  
László Kollár ◽  
Ádám Erdélyi ◽  
Haroon Rasheed ◽  
Attila Takács
Keyword(s):  
Synthetic Method ◽  
Selective Synthesis ◽  
Varied Structure ◽  
Biological Importance ◽  
Aryl Iodides ◽  
Palladium Catalyzed ◽  
Derivatives Of

The aminocarbonylation of various alkenyl and (hetero)aryl iodides was carried out using tropane-based amines of biological importance, such as 8-azabicyclo[3.2.1]octan-3-one (nortropinone) and 3α-hydroxy-8-azabicyclo[3.2.1]octane (nortropine) as N-nucleophile. Using iodoalkenes, the two nucleophiles were selectively converted to the corresponding amide in the presence of Pd(OAc)2/2 PPh3 catalysts. In the presence of several iodo(hetero)arenes, the application of the bidentate Xantphos was necessary to produce the target compounds selectively. The new carboxamides of varied structure, formed in palladium-catalyzed aminocarbonylation reactions, were isolated and fully characterized. In this way, a novel synthetic method has been developed for the producing of N-acylnortropane derivatives of biological importance.

A new synthetic method for an acromelic acid analog, a potent neuroexcitatory kainoid amino acid, via photoinduced benzyl radical cyclization

2002 ◽  
Vol 43 (43) ◽  
pp. 7777-7780 ◽  
Author(s):  
Satoshi Itadani ◽  
Shigeyuki Takai ◽  
Chieko Tanigawa ◽  
Kimiko Hashimoto ◽  
Haruhisa Shirahama
Keyword(s):  
Amino Acid ◽  
Radical Cyclization ◽  
Synthetic Method ◽  
Benzyl Radical ◽  
Acid Analog
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