scholarly journals Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications

2011 ◽  
Vol 7 ◽  
pp. 1294-1298 ◽  
Author(s):  
Bruno Piqani ◽  
Wei Zhang
Keyword(s):  
Microwave Heating ◽  
Multicomponent Reaction ◽  
High Efficiency ◽  
Solid Phase ◽  
Biginelli Reaction ◽  
Suzuki Coupling ◽  
Atom Economy ◽  
Fast Reaction ◽  
Diversity Oriented Synthesis ◽  
Biginelli Reactions

Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind–Srogl reaction and Suzuki coupling to form biaryl-substituted dihydropyrimidinone, dihydropyrimidine, and thiazolopyrimidine compounds. The high efficiency of the diversity-oriented synthesis is achieved by conducting a multicomponent reaction for improved atom economy, under microwave heating for fast reaction, and with fluorous solid-phase extractions (F-SPE) for ease of purification.

An efficient and catalyst-free synthesis of N-arylidene-2-arylimidazo[1,2-a]pyridine-3-ylamine derivatives via Strecker reaction under controlled microwave heating

2017 ◽  
Vol 6 (4) ◽  
Author(s):  
Afaf Mohamed Abdel Hameed ◽  
Moustafa Sherief Moustafa ◽  
Saleh Mohammed Al-Mousawi ◽  
Reham R. Awed ◽  
Kamal Usef Sadek
Keyword(s):  
Microwave Heating ◽  
Multicomponent Reaction ◽  
Aromatic Aldehydes ◽  
Atom Economy ◽  
One Pot ◽  
Strecker Reaction ◽  
Catalyst Free ◽  
Benzoyl Cyanide

AbstractAn efficient one-pot multicomponent reaction of 2-aminopyridine with aromatic aldehydes and either benzoyl cyanide or cyanamide in pyridine under controlled microwave heating afforded N-aryldene-2-arylimidazo[1,2-a]-pyridine-3-ylamine derivatives. The reaction is catalyst free and is of high atom economy.

Solid-phase Bromination and Suzuki Coupling of 2-Carboxyindoles

2001 ◽  
Vol 4 (6) ◽  
pp. 521-524 ◽  
Author(s):  
J. Tois ◽  
R. Franzen ◽  
O. Aitio ◽  
I. Laakso ◽  
J. Huuskonen ◽  
...  
Keyword(s):  
Solid Phase ◽  
Suzuki Coupling

Vegetable oil as a highly effective 100% bio-based alternative solvent for the one-pot multicomponent Biginelli reaction

2021 ◽  
Author(s):  
Pakin Noppawan ◽  
Suwiwat Sangon ◽  
Nontipa Supanchaiyamat ◽  
Andrew J. Hunt
Keyword(s):  
Vegetable Oil ◽  
Palm Oil ◽  
Biginelli Reaction ◽  
Environmentally Friendly ◽  
One Pot ◽  
Highly Effective ◽  
The One ◽  
Biginelli Reactions

Multicomponent one-pot Biginelli reactions have been successfully performed using vegetable oil as bio-based, non-toxic, and environmentally friendly solvents. Palm oil was demonstrated to be a highly effective greener solvent as...

High-Efficiency On-Line Solid-Phase Extraction Coupling to 15−150-μm-i.d. Column Liquid Chromatography for Proteomic Analysis

2003 ◽  
Vol 75 (14) ◽  
pp. 3596-3605 ◽  
Author(s):  
Yufeng Shen ◽  
Ronald J. Moore ◽  
Rui Zhao ◽  
Josip Blonder ◽  
Deanna L. Auberry ◽  
...  
Keyword(s):  
Column Liquid Chromatography ◽  
Liquid Chromatography ◽  
Solid Phase Extraction ◽  
Proteomic Analysis ◽  
High Efficiency ◽  
Solid Phase ◽  
Phase Extraction ◽  
On Line

Solid-Phase Decarburization of High-Carbon Ferromanganese Powders by Microwave Heating

2013 ◽  
Vol 20 (8) ◽  
pp. 34-40 ◽  
Author(s):  
Li-na Guo ◽  
Jin Chen ◽  
Wen-li Shi ◽  
Jing Zhao ◽  
Ke Liu ◽  
...  
Keyword(s):  
Microwave Heating ◽  
Solid Phase ◽  
High Carbon ◽  
High Carbon Ferromanganese

Thermal Analysis of Multijet Impingement Through Porous Media to Design a Confined Heat Management System

2019 ◽  
Vol 141 (8) ◽  
Author(s):  
Carlos Zing ◽  
Shadi Mahjoob
Keyword(s):  
Porous Media ◽  
High Efficiency ◽  
Solid Phase ◽  
Electronics Cooling ◽  
Jet Impingement ◽  
Fluid Phase ◽  
Volume Averaging ◽  
High Heat Flux ◽  
Base Temperature ◽  
Heat Management

Thermal management has a key role in the development of advanced electronic devices to keep the device temperature below a maximum operating temperature. Jet impingement and high conductive porous inserts can provide a high efficiency cooling and temperature control for a variety of applications including electronics cooling. In this work, advanced heat management devices are designed and numerically studied employing single and multijet impingement through porous-filled channels with inclined walls. The base of these porous-filled nonuniform heat exchanging channels will be in contact with the devices to be cooled; as such the base is subject to a high heat flux leaving the devices. The coolant enters the heat exchanging device through single or multijet impingement normal to the base, moves through the porous field and leaves through horizontal exit channels. For numerical modeling, local thermal nonequilibrium model in porous media is employed in which volume averaging over each of the solid and fluid phase results in two energy equations, one for solid phase and one for fluid phase. The cooling performance of more than 30 single and multijet impingement designs are analyzed and compared to achieve advantageous designs with low or uniform base temperature profiles and high thermal effectiveness. The effects of porosity value and employment of 5% titanium dioxide (TiO2) in water in multijet impingement cases are also investigated.

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