scholarly journals Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol

2009 ◽  
Vol 5 ◽  
Author(s):  
Mukund G Kulkarni ◽  
Sanjay W Chavhan ◽  
Mahadev P Shinde ◽  
Dnyaneshwar D Gaikwad ◽  
Ajit S Borhade ◽  
...  
Keyword(s):  
Potent Inhibitor ◽  
Cost Effective ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Benign Process ◽  
Practical Synthesis ◽  
Kinesin Eg5

A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monastrol, a potent inhibitor of kinesin Eg5.

scholarly journals One-Pot Synthesis of 1,8-Dioxodecahydroacridines and Polyhydroquinoline using 1,3-Di (bromo or chloro)-5,5-Dimethylhydantoin as a Novel and Green Catalyst under Solvent-Free Conditions

2017 ◽  
Vol 57 (4) ◽  
Author(s):  
Behrooz Maleki ◽  
Reza Tayebee ◽  
Mina Kermanian ◽  
Samaneh Sedigh Ashrafi
Keyword(s):  
Ethyl Acetoacetate ◽  
Ammonium Acetate ◽  
Solvent Free ◽  
Environmentally Benign ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
Green Catalyst ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Hantzsch Condensation

Solvent-free, one-pot synthesis of polyhdroquinoline and 1,8-dioxodecahydroacridine derivatives have been described via Hantzsch condensation of various aldehydes, ammonium acetate with (<em>i</em>) cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate and (<em>ii</em>) cyclic 1,3-dicarbonyl compounds (2 mmoles) in a very simple, efficient, and environmentally benign method using 1,3-(dibromo or dichloro)-5,5-dimethylhydantoin as a cheap, non-toxic and neutral catalyst with up to excellent yields.

scholarly journals H4SiW12O40Catalyzed One-Pot Synthesis of 12-Aryl-8,9,10,12-tetrahydrobenzo[a] Xanthen-11-ones Under Solvent-Free Conditions

2012 ◽  
Vol 9 (2) ◽  
pp. 786-790 ◽  
Author(s):  
A. Hassankhani ◽  
E. Mosaddegh ◽  
S. Y. Ebrahimipour
Keyword(s):  
Catalytic Activity ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Reusable Catalyst ◽  
High Catalytic Activity ◽  
One Pot ◽  
Aryl Aldehydes ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
The One

An efficient and environmentally benign protocol for the one-pot, three-component synthesis of 12-aryl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-one derivatives by condensation of aryl aldehydes, 2-naphthol and dimedone using H4SiW12O40(SiWA) as a reusable catalyst with high catalytic activity was reported. The reaction was carried out at 100 ºC under solvent-free conditions within 15-40 min in 82-91% yield.

One-pot synthesis of 2-hydrazonyl-4-phenylthiazoles via [PDBMDIm]Br-catalyzed reaction under solvent-free conditions

2016 ◽  
Vol 22 (4) ◽  
Author(s):  
Mohammad Nikpassand ◽  
Leila Zare Fekri ◽  
Sina Sanagou
Keyword(s):  
Solvent Free ◽  
Environmentally Benign ◽  
One Pot ◽  
One Pot Synthesis ◽  
Solvent Free Conditions

AbstractA clean and environmentally benign route for the preparation of substituted thiazoles

Facile one-pot synthesis of sugar–thiazolidinone derivatives

2011 ◽  
Vol 89 (11) ◽  
pp. 1382-1386 ◽  
Author(s):  
Ali Darehkordi ◽  
Kazem Saidi ◽  
Somayeh Ghazi
Keyword(s):  
Microwave Irradiation ◽  
Ambient Temperature ◽  
Cost Effective ◽  
Solvent Free ◽  
One Pot ◽  
One Pot Synthesis ◽  
Cost Effective Method ◽  
Solvent Free Conditions ◽  
High Yields

A simple, efficient, and cost-effective method for the synthesis of a series of sugar–thiazolidinone derivatives by a one-pot reaction of the corresponding thiosemicarbazone of d-galactose, d-glucose, and d-mannose compounds in the presence of dimethyl or diethyl acetylenedicarboxylate is described. Two different methods were used and high yields were obtained in both cases: (A) in EtOAC–H2O at an ambient temperature and (B) microwave irradiation under solvent-free conditions.

scholarly journals Versatile Microwave-Assisted and Lanthanum Chloride Catalysed Synthesis of Polysubstituted Imidazoles Using Urea/Thiourea as Benign Source of Ammonia

2012 ◽  
Vol 9 (4) ◽  
pp. 1773-1777 ◽  
Author(s):  
Mohammad Reza Manafi ◽  
Pedram Manafi ◽  
Mohammad Reza Kalaee
Keyword(s):  
Solvent Free ◽  
Lanthanum Chloride ◽  
Environmentally Benign ◽  
One Pot ◽  
Free Condition ◽  
Effective Catalyst ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Solvent Free Condition ◽  
Work Up

Lanthanum chloride was found to be an effective catalyst for the facile and one-pot synthesis of polysubstituted imidazoles under solvent free condition in excellent yields. This method elucidates urea/thiourea, as an environmentally benign source of ammonia for the synthesis of polysubstituted imidazoles. The work-up procedure is very simple and the products don’t require further purification.

scholarly journals Tandem Fries Reaction–Conjugate Addition under Microwave Irradiation in Dry Media; One-pot Synthesis of Flavanones

1999 ◽  
Vol 23 (9) ◽  
pp. 574-575
Author(s):  
Firouz Matloubi Moghaddam ◽  
Mohammad Ghaffarzadeh ◽  
Seyed Hossein Abdi-Oskoui
Keyword(s):  
Microwave Irradiation ◽  
Silica Gel ◽  
Conjugate Addition ◽  
Solvent Free ◽  
Naphthalene Derivatives ◽  
One Pot ◽  
Fries Rearrangement ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Fries Reaction

An AICl3–ZnCl2 mixture supported on silica gel is found to be an efficient medium for the Fries rearrangement of acyloxybenzene or naphthalene derivatives in solvent-free conditions under microwave irradiation.

A Facile and Practical Solvent-Free One-Pot Synthesis of (Z)-4-Methylene-3-selenaquinoline Derivatives from o-Ethynylanilines and Isoselenocyanates¹

Synthesis ◽  
2010 ◽  
Vol 2010 (18) ◽  
pp. 3091-3096 ◽  
Author(s):  
Haruki Sashida ◽  
Chao Pan ◽  
Mamoru Kaname ◽  
Mao Minoura
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
One Pot Synthesis

Solvent-free One-pot Synthesis of 2,2′-dithioxo-[5,5′]bithiazolidinylidene-4,4′-diones

2015 ◽  
Vol 53 (3) ◽  
pp. 989-992 ◽  
Author(s):  
Farough Nasiri ◽  
Amin Zolali ◽  
Sajad Asadbegi
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
One Pot Synthesis
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