scholarly journals From discovery to production: Scale-out of continuous flow meso reactors

2009 ◽  
Vol 5 ◽  
Author(s):  
Peter Styring ◽  
Ana I R Parracho
Keyword(s):  
Chemical Synthesis ◽  
Continuous Flow ◽  
Fixed Bed ◽  
Production Scale ◽  
Seamless Transition ◽  
Full Analysis ◽  
Small Footprint ◽  
Low Volume ◽  
Short Time ◽  
Parallel Reactor

A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch.

On-line Monitoring of Continuous Flow Chemical Synthesis Using a Portable, Small Footprint Mass Spectrometer

2014 ◽  
Vol 25 (10) ◽  
pp. 1794-1802 ◽  
Author(s):  
Tony W. T. Bristow ◽  
Andrew D. Ray ◽  
Anne O’Kearney-McMullan ◽  
Louise Lim ◽  
Bryan McCullough ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Mass Spectrometer ◽  
Continuous Flow ◽  
On Line ◽  
Small Footprint

Design of a continuous flow immobilized-cell reactor for biosynthetical production of L-aspartic acid

1985 ◽  
Vol 50 (10) ◽  
pp. 2122-2133 ◽  
Author(s):  
Jindřich Zahradník ◽  
Marie Fialová ◽  
Jan Škoda ◽  
Helena Škodová
Keyword(s):  
Aspartic Acid ◽  
Continuous Flow ◽  
Immobilized Cells ◽  
Scale Up ◽  
Fixed Bed ◽  
Packed Bed ◽  
Fixed Bed Reactor ◽  
Experimental Program ◽  
Design Parameters ◽  
Immobilized Cell

An experimental study was carried out aimed at establishing a data base for an optimum design of a continuous flow fixed-bed reactor for biotransformation of ammonium fumarate to L-aspartic acid catalyzed by immobilized cells of the strain Escherichia alcalescens dispar group. The experimental program included studies of the effect of reactor geometry, catalytic particle size, and packed bed arrangement on reactor hydrodynamics and on the rate of substrate conversion. An expression for the effective reaction rate was derived including the effect of mass transfer and conditions of the safe conversion-data scale-up were defined. Suggestions for the design of a pilot plant reactor (100 t/year) were formulated and decisive design parameters of such reactor were estimated for several variants of problem formulation.

Metal–organic frameworks for the removal of the emerging contaminant atenolol under real conditions

2021 ◽  
Vol 50 (7) ◽  
pp. 2493-2500
Author(s):  
Sara Rojas ◽  
Jorge A. R. Navarro ◽  
Patricia Horcajada
Keyword(s):  
Continuous Flow ◽  
Metal Organic Frameworks ◽  
Fixed Bed ◽  
Emerging Contaminant ◽  
Flow Conditions ◽  
Metal Organic ◽  
Fixed Bed System

A defective Metal-Organic Frameworks as an improved material for the construction of a fixed-bed system working under continuous flow conditions for the removal of the emerging contaminant atenolol.

Degradation of chlorophenols by biofilms on semi-permeable membranes in two types of fixed bed reactors

1995 ◽  
Vol 32 (8) ◽  
pp. 205-212 ◽  
Author(s):  
A. Wobus ◽  
S. Ulrich ◽  
I. Röske
Keyword(s):  
Continuous Flow ◽  
Plug Flow ◽  
Fixed Bed ◽  
Biofilm Reactor ◽  
Flow Conditions ◽  
Concentration Gradients ◽  
Batch Mode ◽  
Sequencing Batch Biofilm Reactor ◽  
Fixed Bed Reactors ◽  
Protozoan Community

Two identical fixed bed reactors containing gas-permeable tubings as carrier material were compared for the elimination of chlorophenols. Under plug flow conditions, the continuous flow operation resulted in a stratification of biomass due to concentration gradients. To achieve a homogeneous colonization, the sequencing batch mode has been applicated to one biofilm reactor (Sequencing Batch Biofilm Reactor - SBBR). Concentration gradients after filling, probably due to sorption phenomena, caused an uneven distribution of biomass in the SBBR. However, the colonization of the SBBR was more homogeneous as compared to the continuously operated reactor (CFBR). As to the elimination of a trichlorophenol (2,4,5-trichlorophenol - TCP), no significant differences between the SBBR and the CFBR were observed with regard to its sensitivity against load surges. It is to be supposed that sorption to the biofilm was included in the elimination of chlorophenols. A higher diversity of protozoan community and meiofauna is obviously to be attributed to continuous flow.

Zeolite/Cerium Oxide Coat-on Activated Alumina Ball for Arsenite Removal via Fixed- Bed Continuous Flow Adsorption Column

2021 ◽  
Author(s):  
Suttikorn Suwannatrai ◽  
Dickson Y. S. Yan ◽  
Pummarin Khamdahsag ◽  
Visanu Tanboonchuy
Keyword(s):  
Cerium Oxide ◽  
Flow Rate ◽  
Continuous Flow ◽  
Human Life ◽  
Fixed Bed ◽  
Point Of Zero Charge ◽  
Contaminated Water ◽  
Activated Alumina ◽  
Initial Flow ◽  
Alumina Ball

Arsenite (As(III)) has threatened human life for ages. It is a necessity to remove As(III) from the contaminated water before general use. With the improvement of adsorption, higher As(III) removal can be achieved. This study aimed to develop zeolite/cerium oxide coat-on activated alumina ball adsorbent (CeZ-ball) with the aid of PVA binder and apply it to a fixed-bed continuous flow column for As(III) adsorption. The coating percentage of CeZ-ball was studied. Cerium ions leaching from CeZ-ball were monitored throughout the 2,880-min-column run to confirm the stability of CeZ attached to an activated alumina ball. Surface area, pH point of zero charge, and structural property of CeZ-ball were characterized. An average CeZ coating of 83.3% and rare leaching of cerium proved the coating method. The models proposed by Yoon-Nelson provided the most satisfactory fit with the breakthrough curve (r2 = 0.985, MPSD = 2.547, and q0 = 3.481 mg·g–1) under experimental conditions of the flow rate of 5 mL·min–1, As(III) influent concentration of 1 mg·L–1, and CeZ-ball weight of 40 g. The half-time of breakthrough (τ) was 1,228.739 min. The effects of the key parameters, including initial adsorbent weight, initial flow rate, and initial As(III) concentration, were investigated for the performance of As(III) adsorption. Simulated from the Yoon-Nelson model, the τ increased as well as the adsorbent weight but decreased as the flow rate increased, thus impacting the As(III) concentration. With the optimal condition, the fixed-bed continuous column with CeZ-ball could be used in As(III) removal from contaminated water.

scholarly journals Catalytic Methods in Flow Chemistry

Catalysts ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 663
Author(s):  
Christophe Len ◽  
Renzo Luisi
Keyword(s):  
Chemical Synthesis ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
Pharmaceutical Companies ◽  
Enabling Technology ◽  
Continuous Flow Chemistry ◽  
The Way

Continuous flow chemistry is radically changing the way of performing chemical synthesis, and several chemical and pharmaceutical companies are now investing in this enabling technology [...]

Continuous flow reduction of organic dyes over Pd-Fe alloy based fibrous catalyst in a fixed-bed system

2021 ◽  
Vol 231 ◽  
pp. 116303
Author(s):  
Jiangbo Xi ◽  
Qijun Wang ◽  
Xianming Duan ◽  
Ning Zhang ◽  
Junxia Yu ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Organic Dyes ◽  
Fixed Bed ◽  
Flow Reduction ◽  
Fixed Bed System

scholarly journals Comparing hexacyanoferrate loaded onto silica, silicotitanate and chabazite sorbents for Cs extraction with a continuous-flow fixed-bed setup: Methods and pitfalls

2020 ◽  
Vol 134 ◽  
pp. 371-380 ◽  
Author(s):  
Agnès Grandjean ◽  
Yves Barré ◽  
Audrey Hertz ◽  
Virginie Fremy ◽  
Jérémy Mascarade ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Fixed Bed
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