Chemical synthesis of d(G-C)4, d(G-C)5 and d(GGTGGACCTC) by continuous flow solid phase phosphotriester method

1985 ◽  
Vol 95 (4) ◽  
Author(s):  
G V Rajendrakumar ◽  
N Sivakama Sundari ◽  
K N Ganesh
Keyword(s):  
Chemical Synthesis ◽  
Continuous Flow ◽  
Solid Phase ◽  
Phosphotriester Method

Development of Strategies for Glycopeptide Synthesis: An Overview on the Glycosidic Linkage

2020 ◽  
Vol 24 (21) ◽  
pp. 2475-2497
Author(s):  
Andrea Verónica Rodríguez-Mayor ◽  
German Jesid Peralta-Camacho ◽  
Karen Johanna Cárdenas-Martínez ◽  
Javier Eduardo García-Castañeda
Keyword(s):  
Chemical Synthesis ◽  
Solid Phase ◽  
Building Blocks ◽  
Heterogeneous Environments ◽  
Phase Synthesis ◽  
Low Concentrations ◽  
Biological Sources ◽  
Synthetic Routes ◽  
The Impact ◽  
Potential Use

Glycoproteins and glycopeptides are an interesting focus of research, because of their potential use as therapeutic agents, since they are related to carbohydrate-carbohydrate, carbohydrate-protein, and carbohydrate-lipid interactions, which are commonly involved in biological processes. It has been established that natural glycoconjugates could be an important source of templates for the design and development of molecules with therapeutic applications. However, isolating large quantities of glycoconjugates from biological sources with the required purity is extremely complex, because these molecules are found in heterogeneous environments and in very low concentrations. As an alternative to solving this problem, the chemical synthesis of glycoconjugates has been developed. In this context, several methods for the synthesis of glycopeptides in solution and/or solid-phase have been reported. In most of these methods, glycosylated amino acid derivatives are used as building blocks for both solution and solid-phase synthesis. The synthetic viability of glycoconjugates is a critical parameter for allowing their use as drugs to mitigate the impact of microbial resistance and/or cancer. However, the chemical synthesis of glycoconjugates is a challenge, because these molecules possess multiple reaction sites and have a very specific stereochemistry. Therefore, it is necessary to design and implement synthetic routes, which may involve various protection schemes but can be stereoselective, environmentally friendly, and high-yielding. This review focuses on glycopeptide synthesis by recapitulating the progress made over the last 15 years.

scholarly journals Enzyme‐cleavable linkers for protein chemical synthesis through solid‐phase ligations.

2021 ◽  
Author(s):  
Vincent Aucagne ◽  
Skander A Abboud ◽  
Mehdi Amoura ◽  
Jean-Baptiste Madinier ◽  
Brigitte Renoux ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Solid Phase

Plasma-chemical synthesis of YBa2Cu3O7–y / CuO granular composites

2021 ◽  
pp. 32-37
Author(s):  
Igor Karpov ◽  
◽  
Anatoly Ushakov ◽  
Leonid Fedorov ◽  
Lylya Irtyugo ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Chemical Reactor ◽  
Reaction Chamber ◽  
Plasma Chemical ◽  
Plasma Chemical Reactor ◽  
Phase Synthesis ◽  
Pinning Centers ◽  
Granular Composites

The possibility of synthesizing HTSC ceramics in the reaction chamber of a plasma-chemical reactor is shown. The method allows one to significantly reduce the process of solid-phase synthesis and obtain modified HTSC ceramics with a given content of non-superconducting additives that act as pinning centers.

scholarly journals The Breaking Beads Approach for Photocleavage from Solid Support

2020 ◽  
Author(s):  
yasmeen bakhatan ◽  
Israel Alshanski ◽  
Dana Grunhaus ◽  
Mattan Hurevich
Keyword(s):  
Continuous Flow ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
High Energy ◽  
Solid Support ◽  
Phase Synthesis ◽  
Polystyrene Beads ◽  
Magnetic Stirring ◽  
Photolabile Linkers

Photocleavage from polystyrene beads is a pivotal reaction for solid phase synthesis that relies on photolabile linkers. The photocleavage, usually performed by batch irradiation, suffers from incomplete and slow cleavage. To overcome these issues, continuous flow and high-energy lamps are frequently used, but these setups are hazardous, technically challenging, and expensive. We developed a photocleavage approach that relies on a benchtop LED lamp and magnetic stirring. In this approach, we crush the beads instead of keeping their integrity to increase the yield of photocleavage. This approach proved very efficient for photocleavage of protected oligosaccharides.

Efficient Solid-Phase Chemical Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogues

2010 ◽  
Vol 12 (10) ◽  
pp. 2190-2193 ◽  
Author(s):  
Ivan Zlatev ◽  
Thomas Lavergne ◽  
Françoise Debart ◽  
Jean-Jacques Vasseur ◽  
Muthiah Manoharan ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Solid Phase ◽  
Phase Chemical

Continuous flow solid phase peptide synthesis on perfusive media

Peptides 1994 ◽  
1995 ◽  
pp. 277-278
Author(s):  
B. F. McGuinness ◽  
S. D. Britt ◽  
N. Mu ◽  
D. Whitney ◽  
N. Afeyan
Keyword(s):  
Peptide Synthesis ◽  
Continuous Flow ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis
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