scholarly journals Asymmetric reactions in continuous flow

2009 ◽  
Vol 5 ◽  
Author(s):  
Xiao Yin Mak ◽  
Paola Laurino ◽  
Peter H Seeberger
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Catalysis ◽  
Continuous Flow ◽  
Asymmetric Reactions ◽  
Heterogeneous Asymmetric Catalysis

An overview of asymmetric synthesis in continuous flow and microreactors is presented in this review. Applications of homogeneous and heterogeneous asymmetric catalysis as well as biocatalysis in flow are discussed.

Fine Chemicals Synthesis by Heterogeneous Asymmetric Catalysis

1994 ◽  
Vol 368 ◽  
Author(s):  
Kam T. Wan ◽  
Mark E. Davis
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Catalysis ◽  
Industrial Application ◽  
Antiinflammatory Drug ◽  
Fine Chemicals ◽  
Chiral Catalyst ◽  
Heterogeneous Asymmetric Catalysis

ABSTRACTThe application of heterogeneous asymmetric catalysis to fine chemicals synthesis is discussed. The asymmetric synthesis of naproxen, a non-steroidal antiinflammatory drug, using a novel, heterogeneous, chiral catalyst is used as an example to illustrate the feasibility to industrial application.

Strategies of In Situ Generated Magnesium Catalysis in Asymmetric Reactions

Synlett ◽  
2021 ◽  
Author(s):  
Dongxu Yang ◽  
Linqing Wang
Keyword(s):  
Asymmetric Synthesis ◽  
Alkaline Earth ◽  
Earth Metal ◽  
Asymmetric Reactions ◽  
Chiral Ligands ◽  
Alkaline Earth Metal ◽  
Enantioselective Reactions ◽  
Earth's Crust

AbstractMagnesium (Mg) is a cheap, non-toxic, and recyclable alkaline earth metal that constitutes about 2% weight in the Earth’s crust. The use of magnesium catalysts to forge chiral moieties in molecules is highly attractive. Based on our work in recent years, we describe the current progress in the development of in situ generated magnesium catalysts and their application in asymmetric synthesis. In this perspective, a critically concise classification of in situ generated magnesium catalytic modes, with relevant examples, is presented, and representative mechanisms of each category are discussed. Building on the established diverse strategies, one can foresee that more innovative and structurally creative magnesium catalysts that are generated in situ will be developed to overcome more formidable challenges of catalytic enantioselective reactions.1 Introduction2 Magnesium Catalysts Generated in Situ from Chiral Ligands Containing Dual Reactive Hydrogens3 Magnesium Catalysts Generated in Situ from Monoanionic Chiral Ligands4 Bimetallic and Polymetallic Magnesium Catalysts Assembled in Situ5 Summary and Outlook

Carbonyl catalysis enables a biomimetic asymmetric Mannich reaction

Science ◽  
2018 ◽  
Vol 360 (6396) ◽  
pp. 1438-1442 ◽  
Author(s):  
Jianfeng Chen ◽  
Xing Gong ◽  
Jianyu Li ◽  
Yingkun Li ◽  
Jiguo Ma ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
High Activity ◽  
Asymmetric Catalysis ◽  
Carbonyl Group ◽  
Mannich Reaction ◽  
Primary Amine ◽  
Chiral Amines ◽  
Carbonyl Groups ◽  
Diphenylphosphinyl Imines

Chiral amines are widely used as catalysts in asymmetric synthesis to activate carbonyl groups for α-functionalization. Carbonyl catalysis reverses that strategy by using a carbonyl group to activate a primary amine. Inspired by biological carbonyl catalysis, which is exemplified by reactions of pyridoxal-dependent enzymes, we developed an N-quaternized pyridoxal catalyst for the asymmetric Mannich reaction of glycinate with aryl N-diphenylphosphinyl imines. The catalyst exhibits high activity and stereoselectivity, likely enabled by enzyme-like cooperative bifunctional activation of the substrates. Our work demonstrates the catalytic utility of the pyridoxal moiety in asymmetric catalysis.

scholarly journals Chiral salen complexes in polymeric main-chains for heterogeneous asymmetric catalysis - a brief account

2020 ◽  
Vol 58 (1) ◽  
pp. 29-39
Author(s):  
Hiba Dandachi ◽  
Xiang Hong ◽  
Farah Ibrahim ◽  
Houssein Nasrallah ◽  
Anaïs Zulauf ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Salen Complexes ◽  
Heterogeneous Asymmetric Catalysis ◽  
Chiral Salen Complexes

Deconjugated butenolide: a versatile building block for asymmetric catalysis

2020 ◽  
Vol 49 (18) ◽  
pp. 6755-6788 ◽  
Author(s):  
Abhijnan Ray Choudhury ◽  
Santanu Mukherjee
Keyword(s):  
Asymmetric Catalysis ◽  
Building Block ◽  
Enantioselective Synthesis ◽  
Asymmetric Reactions ◽  
Comprehensive Overview ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Reactions

Deconjugated butenolides have emerged as a popular synthon for the enantioselective synthesis of γ-lactones. This review provides a comprehensive overview on the catalytic asymmetric reactions of deconjugated butenolides reported till date.

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