scholarly journals Evidence for state-dependent learning with mescaline in a passive avoidance task

1971 ◽  
Vol 25 (5) ◽  
pp. 260-261 ◽  
Author(s):  
Ronald K. Siegel ◽  
Murray E. Jarvik
Keyword(s):  
Passive Avoidance ◽  
Passive Avoidance Task ◽  
Avoidance Task ◽  
State Dependent Learning ◽  
State Dependent ◽  
Dependent Learning

Is anisomycin-induced amnesia for a passive avoidance task in chicks the result of state-dependent learning?

1989 ◽  
Vol 49 (2) ◽  
pp. 179-184 ◽  
Author(s):  
D.W. Lee ◽  
A.M. Perlmutter ◽  
D.S. Beniston ◽  
E.L. Bennett ◽  
M.R. Rosenzweig
Keyword(s):  
Passive Avoidance ◽  
Passive Avoidance Task ◽  
Avoidance Task ◽  
State Dependent Learning ◽  
State Dependent ◽  
Dependent Learning

Effects of morphine on the plus-maze discriminative avoidance task: role of state-dependent learning

2005 ◽  
Vol 184 (1) ◽  
pp. 1-12 ◽  
Author(s):  
C. L. Patti ◽  
S. R. Kameda ◽  
R. C. Carvalho ◽  
A. L. Takatsu-Coleman ◽  
G. B. Lopez ◽  
...  
Keyword(s):  
Avoidance Task ◽  
State Dependent Learning ◽  
State Dependent ◽  
Plus Maze ◽  
Dependent Learning

Benzodiazepine blockade of passive-avoidance task in mice: A state-dependent phenomenon

1979 ◽  
Vol 61 (1) ◽  
pp. 25-28 ◽  
Author(s):  
J. B. Patel ◽  
V. B. Ciofalo ◽  
L. C. Iorio
Keyword(s):  
Passive Avoidance ◽  
Passive Avoidance Task ◽  
Avoidance Task ◽  
State Dependent

scholarly journals Role of state-dependent learning in the cognitive effects of caffeine in mice

2013 ◽  
Vol 16 (7) ◽  
pp. 1547-1557 ◽  
Author(s):  
Leandro Sanday ◽  
Karina A. Zanin ◽  
Camilla L. Patti ◽  
Luciano Fernandes-Santos ◽  
Larissa C. Oliveira ◽  
...  
Keyword(s):  
Inhibitory Avoidance ◽  
Memory Deficits ◽  
Avoidance Task ◽  
Test Administration ◽  
Cognitive Effects ◽  
State Dependent Learning ◽  
State Dependency ◽  
State Dependent ◽  
Plus Maze ◽  
Dependent Learning

Abstract Caffeine is the most widely used psychoactive substance in the world and it is generally believed that it promotes beneficial effects on cognitive performance. However, there is also evidence suggesting that caffeine has inhibitory effects on learning and memory. Considering that caffeine may have anxiogenic effects, thus changing the emotional state of the subjects, state-dependent learning may play a role in caffeine-induced cognitive alterations. Mice were administered 20 mg/kg caffeine before training and/or before testing both in the plus-maze discriminative avoidance task (an animal model that concomitantly evaluates learning, memory, anxiety-like behaviour and general activity) and in the inhibitory avoidance task, a classic paradigm for evaluating memory in rodents. Pre-training caffeine administration did not modify learning, but produced an anxiogenic effect and impaired memory retention. While pre-test administration of caffeine did not modify retrieval on its own, the pre-test administration counteracted the memory deficit induced by the pre-training caffeine injection in both the plus-maze discriminative and inhibitory avoidance tasks. Our data demonstrate that caffeine-induced memory deficits are critically related to state-dependent learning, reinforcing the importance of considering the participation of state-dependency on the interpretation of the cognitive effects of caffeine. The possible participation of caffeine-induced anxiety alterations in state-dependent memory deficits is discussed.

Cross state-dependency of learning between 5-HT1A and/or 5-HT7 receptor agonists and muscimol in the mouse dorsal hippocampus

2019 ◽  
Vol 33 (6) ◽  
pp. 722-736 ◽  
Author(s):  
Majid Jafari-Sabet ◽  
Sepehr Nemati ◽  
Mansour Torab
Keyword(s):  
Memory Retrieval ◽  
Cognitive Disorders ◽  
Avoidance Task ◽  
State Dependent Learning ◽  
State Dependency ◽  
Gaba A ◽  
State Dependent ◽  
Dorsal Hippocampal ◽  
Hippocampal Ca1 ◽  
Dependent Learning

Background: Dysfunction of the serotonergic and GABAergic systems in cognitive disorders has been revealed. Understanding the neurobiological mechanisms of drug-associated learning and memory formation may help treatment of cognitive disorders. Aims: The aim of the present study was to investigate: 1) 8-OH-DPAT (5-HT1A agonist), AS19 (5-HT7 agonist) and muscimol (GABA-A agonist) on memory retrieval and state of memory, 2) cross state-dependent learning between 8-OH-DPAT and/or AS19 and muscimol. Methods: The dorsal hippocampal CA1 regions of adult male NMRI mice were bilaterally cannulated, and all drugs were microinjected into the intended sites of injection. A single-trial step-down inhibitory avoidance task was used for the evaluation of memory retrieval and state of memory. Results: Post-training and/or pre-test 8-OH-DPAT, AS19 and muscimol induced amnesia. Pre-test microinjection of the same doses of 8-OH-DPAT, AS19 and muscimol reversed the post-training 8-OH-DPAT-, AS19- and muscimol-induced amnesia, respectively. This event has been named state-dependent learning (SDL). The amnesia induced by 8-OH-DPAT was reversed by muscimol and induced 8-OH-DPAT SDL. The amnesia induced by muscimol was reversed by 8-OH-DPAT and induced muscimol SDL. The amnesia induced by AS19 was reversed by muscimol and induced AS19 SDL. The amnesia induced by muscimol was reversed by AS19 and induced muscimol SDL. Pre-test administration of a selective GABA-A receptor antagonist, bicuculline, 5 min before muscimol, 8-OH-DPAT and AS19 dose-dependently inhibited muscimol-, 8-OH-DPAT- and AS19-induced SDL, respectively. Conclusions: The results strongly revealed a cross SDL among 8-OH-DPAT and/or AS19 and muscimol in the dorsal hippocampal CA1 regions.

N-methyl-D-aspartate Receptors are Involved in the Effect of Lithium on Passive Avoidance Memory in Mice

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M.-R. Zarrindast ◽  
H. Niasari ◽  
S. Ahmadi ◽  
B. Shafaghi
Keyword(s):  
Nmda Receptor ◽  
Passive Avoidance ◽  
Receptor Agonist ◽  
Nmda Receptor Antagonist ◽  
Passive Avoidance Task ◽  
Avoidance Task ◽  
Test Administration ◽  
Mk 801 ◽  
Memory Assessment ◽  
State Dependent

In the present study, the effects of intracerebroventricular (i.c.v.) injections of N-methyl-D-aspartate (NMDA) receptor agonist and antagonist on the lithium state-dependent memory have been investigated. For memory assessment, one-trial step-down passive avoidance task was used in adult male NMRI mice. Post-training intraperitoneal (i.p.) administration of lithium (10 mg/kg) impaired the memory of passive avoidance task. Pre-test administration of the same dose of the drug (10 mg/kg) restored impairment of memory by lithium given after training. This is known as state-dependent memory. In addition, pre-test administration of both NMDA receptor agonist (NMDA; 0.01 and 0.1 ng/mouse, i.c.v.) and the non-competitive NMDA receptor antagonist, MK-801 (0.1 and 0.5 mg/mouse, i.c.v) also restored impairment of memory induced by post-training lithium. On the other hand, pre-test co-administration of ineffective dose of NMDA (0.001 ng/mouse, i.c.v.) or MK-801 (0.001 mg/mouse, i.c.v) with lower doses of lithium (1.25, 2.5 and 5 mg/kg, i.p.) increased the restoration of memory by lithium. The results suggest that NMDA receptors are involved, at least partly, in the lithium state-dependent memory of passive avoidance task.

Intra-Dorsal Hippocampal Microinjection of Lithium and Scopolamine Induce a Cross State-Dependent Learning in Mice

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
B. Ghorbanalizadeh-Khalifeh-Mahaleh ◽  
S. Taheri ◽  
M. Sahengharani ◽  
A. Rezayof ◽  
A. Haeri-Rohani ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Memory Function ◽  
Avoidance Task ◽  
Test Administration ◽  
State Dependent Learning ◽  
State Dependency ◽  
Impaired Memory ◽  
State Dependent ◽  
Dorsal Hippocampal ◽  
Dependent Learning

Background:Lithium a mood stabilizer may exert adverse effects on memory. We have previously shown that lithium induces state-dependent learning. Cholinergic systems of the brain may play an important role in memory function and mood regulation. In the present study, effects of intra-dorsal hippocampal (intra-CA1) injections of lithium and scopolamine on memory and cross state-dependent learning between two drugs were investigated.Methods:For memory assessment, a one-trial step-down inhibitory avoidance task was used in adult male NMRI mice.Results:Intra-CA1 administration of lithium (0.5 and 1 μg/mouse) after training or injection of the drug (0.5μg/mouse) before testing impaired memory when retrieval was tested 24 h later. The memory impairment by post-training lithium was reversed by pre-test administration of the drug (0.5μg/mouse, intra-CA1) suggesting lithium state-dependent learning. On the other hand, intra-CA1 administration of scopolamine (0.5, 1 and 2 μg/mouse) after training or injection of the drug (2μg/mouse) before testing impaired memory when retrieval was tested 24 h later. The impairment of memory by post-training injection of scopolamine (2μg/mouse) was restored by the pre-test injection of the drug (1 and 2 μg/mouse). Furthermore, memory impairment induced by post-training injection of lithium (0.5 μg/mouse) and scopolamine (2 μg/mouse) were reversed by pre-test administration of scopolamine (0.5, 1 and 2 μg/mouse) and lithium (0.5 and 1 μg/mouse) respectively. The impairment by lithium was also reversed by physostigmine.Conclusion:The results suggest that microinjection of both lithium and scopolamine induce state-dependent memory and there may be a cross state-dependency between two drugs.

scholarly journals Amphetamine-induced memory impairment in a discriminative avoidance task is state-dependent in mice

2013 ◽  
Vol 16 (3) ◽  
pp. 583-592 ◽  
Author(s):  
Leandro Sanday ◽  
Camilla L. Patti ◽  
Karina A. Zanin ◽  
Sergio Tufik ◽  
Roberto Frussa-Filho
Keyword(s):  
Memory Impairment ◽  
Internal State ◽  
Laboratory Animals ◽  
Avoidance Task ◽  
Cognitive Effects ◽  
General Activity ◽  
State Dependent Learning ◽  
State Dependency ◽  
State Dependent ◽  
Dependent Learning

Abstract In both humans and laboratory animals, the reports of cognitive effects following acute amphetamine (Amph) administration are mixed and depend, for example, on the timing of administration (e.g. before or after task acquisition) and/or on the memory model used. Besides its cognitive effects, Amph produces other important behavioural effects, including alterations in anxiety and general activity, which could modify the subject's internal state, thereby facilitating state-dependent learning. Importantly, state-dependency has been linked to drug dependence in humans. This study evaluates the role of state-dependent learning in Amph-induced memory deficits in mice submitted to a discriminative avoidance task. Mice were given Amph (3 mg/kg) before training and/or before testing in the plus-maze discriminative avoidance task, an animal model that concomitantly evaluates learning, memory, anxiety-like behaviour and general activity. Pre-training Amph administration did not affect the ability to learn the discriminative task, but rather induced anxiogenic-like effects and a marked retention deficit in the test session. This memory impairment was completely absent when animals received Amph before both the training and the test sessions. Amph-induced memory impairment of a discriminative avoidance task is state-dependent, such that a response acquired in the ‘Amph state’ cannot be recalled in the normal state. The involvement of anxiety alterations in this ‘Amph state’ is discussed.

Sign in / Sign up

Export Citation Format

Share Document